The DOI matches its OpenAlex record; 4 of the 4 references it cites were found in a registry or an index.
Toxicity of Nanoparticles and an Overview of Current Experimental Models.
Open accessAbstract
Nanotechnology is a rapidly growing field having potential applications in many areas. Nanoparticles (NPs) have been studied for cell toxicity, immunotoxicity, and genotoxicity. Tetrazolium-based assays such as MTT, MTS, and WST-1 are used to determine cell viability. Cell inflammatory response induced by NPs is checked by measuring inflammatory biomarkers, such as IL-8, IL-6, and tumor necrosis factor, using ELISA. Lactate dehydrogenase (LDH) assay is used for cell membrane integrity. Different types of cell cultures, including cancer cell lines have been employed as in vitro toxicity models. It has been generally agreed that NPs interfere with either assay materials or with detection systems. So far, toxicity data generated by employing such models are conflicting and inconsistent. Therefore, on the basis of available experimental models, it may be difficult to judge and list some of the more valuable NPs as more toxic to biological systems and vice versa. Considering the potential applications of NPs in many fields and the growing apprehensions of FDA about the toxic potential of nanoproducts, it is the need of the hour to look for new internationally agreed free of bias toxicological models by focusing more on in vivo studies.
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Cites
Passage of inhaled particles into the blood circulation in humans
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Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats
Zhu, M.-T., Feng, W.-Y., Wang, B., Wang, T.-C., Gu, Y.-Q., Wang, M., Wang, Y., Ouyang, H., Zhao, Y.-L., & Chai, Z.-F. (2008) · Toxicology · doi:10.1016/j.tox.2008.02.011 · Cited by 276
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Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
Micro- and nanoplastic induced cellular toxicity in mammals: A review
Banerjee, A., & Shelver, W. L. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142518 · Cited by 492
The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
Awashra, M., & Młynarz, P. (2023) · Nanoscale Advances · doi:10.1039/d2na00534d · Cited by 319
Polymer-Based Nanomaterials for Drug-Delivery Carriers
Yadav, H. K. S., Almokdad, A. A., shaluf, S. I. M., & Debe, M. S. (2019) · Nanocarriers for Drug Delivery · doi:10.1016/b978-0-12-814033-8.00017-5 · Cited by 148
Metadata
- Authors
- Bahadar, H., Maqbool, F., Niaz, K., & Abdollahi, M. R.
- Venue
- PubMed
- Publisher
- National Institutes of Health
- Published
- 2016-01-01
- Volume
- 20
- Issue
- 1
- Pages
- 1-11
- OpenAlex
- W1950590558
- Cited by
- 643
- References
- 4
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Bahadar, H., Maqbool, F., Niaz, K., & Abdollahi, M. R. (2016). Toxicity of Nanoparticles and an Overview of Current Experimental Models. PubMed. https://doi.org/10.7508/ibj.2016.01.001
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