Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Open accessAbstract
Nonspecific distribution and uncontrollable release of drugs in conventional drug delivery systems (CDDSs) have led to the development of smart nanocarrier-based drug delivery systems, which are also known as Smart Drug Delivery Systems (SDDSs). SDDSs can deliver drugs to the target sites with reduced dosage frequency and in a spatially controlled manner to mitigate the side effects experienced in CDDSs. Chemotherapy is widely used to treat cancer, which is the second leading cause of death worldwide. Site-specific drug delivery led to a keen interest in the SDDSs as an alternative to chemotherapy. Smart nanocarriers, nanoparticles used to carry drugs, are at the focus of SDDSs. A smart drug delivery system consists of smart nanocarriers, targeting mechanisms, and stimulus techniques. This review highlights the recent development of SDDSs for a number of smart nanocarriers, including liposomes, micelles, dendrimers, meso-porous silica nanoparticles, gold nanoparticles, super paramagnetic iron-oxide nanoparticles, carbon nanotubes, and quantum dots. The nanocarriers are described in terms of their structures, classification, synthesis and degree of smartness. Even though SDDSs feature a number of advantages over chemotherapy, there are major concerns about the toxicity of smart nanocarriers; therefore, a substantial study on the toxicity and biocompatibility of the nanocarriers has been reported. Finally, the challenges and future research scope in the field of SDDSs are also presented. It is expected that this review will be widely useful for those who have been seeking new research directions in this field and for those who are about to start their studies in smart nanocarrier-based drug delivery.
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Almost all solid tumors are prone to speeding up the rate of glycolysis by generating a bulking amount of lactic acid to provide adequate energy for tumor cells.
“Almost all solid tumors are prone to speeding up the rate of glycolysis by generating a bulking amount of lactic acid to provide adequate energy for tumor cells. This truncated pathway is also known as the Warburg effect of converting glucose directly into lactic acid.136”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [136]
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Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
- Authors
- Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J.
- Affiliations
- Bangladesh Atomic Energy Commission (BD)
- University of Rajshahi (BD)
- Kwangwoon University (KR)
- Corresponding author
- Hossain, M. Khalid
- Venue
- Journal of Advanced Research
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 15
- Pages
- 1-18
- ISSN
- 2090-1224 (ISSN-L)
- 2090-1232
- PMC
- PMC6300464
- OpenAlex
- W2811478723
- Cited by
- 998
- References
- 307
- Citations by year
- 2026: 56 · 2025: 111 · 2024: 153 · 2023: 164 · 2022: 176 · 2021: 176 · 2020: 114 · 2019: 47 · 2018: 1
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Advanced Research (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- smart drug delivery, smart nanocarriers, cancer therapy, targeted drug delivery, liposomes, micelles, dendrimers, mesoporous silica nanoparticles, gold nanoparticles, superparamagnetic iron oxide nanoparticles, carbon nanotubes, quantum dots, nanocarrier toxicity, biocompatibility, chemotherapy side effects
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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