The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Early patterning and specification of cardiac progenitors in gastrulating mesoderm
Open accessAbstract
Mammalian heart development requires precise allocation of cardiac progenitors. The existence of a multipotent progenitor for all anatomic and cellular components of the heart has been predicted but its identity and contribution to the two cardiac progenitor ‘fields’ has remained undefined. Here we show, using clonal genetic fate mapping, that Mesp1+ cells in gastrulating mesoderm are rapidly specified into committed cardiac precursors fated for distinct anatomic regions of the heart. We identify Smarcd3 as a marker of early specified cardiac precursors and identify within these precursors a compartment boundary at the future junction of the left and right ventricles that arises prior to morphogenesis. Our studies define the timing and hierarchy of cardiac progenitor specification and demonstrate that the cellular and anatomical fate of mesoderm-derived cardiac cells is specified very early. These findings will be important to understand the basis of congenital heart defects and to derive cardiac regeneration strategies.
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Cites
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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816 · cited 1×
“At least two sets of molecularly and morphologically distinct cardiac precursors have been identified in the mammalian embryo, referred to as the first and second heart fields; these populations contribute to distinct anatomical structures within the heart (Evans et al., 2010; Buckingham et al.,…”
BackgroundMending broken hearts: cardiac development as a basis for adult heart regeneration and repair
Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514
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Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium
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Extensions of MADM (mosaic analysis with double markers) in mice
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Cited by
Loh, K. M., Chen, A., Koh, P. W., Deng, T. Z., Sinha, R., Tsai, J. M., Barkal, A. A., Shen, K. Y., Jain, R., Morganti, R. M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.011 · Cited by 489
Protze, S. I., Lee, J. H., & Keller, G. M. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.07.010 · Cited by 162
In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
Lee, J., Sutani, A., Kaneko, R., Takeuchi, J., Sasano, T., Kohda, T., Ihara, K., Takahashi, K., Yamazoe, M., Morio, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18031-5 · Cited by 154
Precardiac organoids form two heart fields via Bmp/Wnt signaling
Andersen, P., Tampakakis, E., Jimenez, D. V., Kannan, S., Miyamoto, M., Shin, H. K., Saberi, A., Murphy, S., Sulistio, E., Chelko, S. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05604-8 · Cited by 132
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease
Kathiriya, I. S., Rao, K. S., Iacono, G., Devine, W. P., Blair, A. P., Hota, S. K., Lai, M. H., Garay, B. I., Thomas, R., Gong, H. Z., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2020.11.020 · Cited by 116
Self-citation
Metadata
- Authors
- Devine, W. P., Wythe, J. D., George, M., Koshiba-Takeuchi, K., & Bruneau, B. G.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-10-08
- Volume
- 3
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2110997400
- Cited by
- 253
- References
- 6
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Devine, W. P., Wythe, J. D., George, M., Koshiba-Takeuchi, K., & Bruneau, B. G. (2014). Early patterning and specification of cardiac progenitors in gastrulating mesoderm. eLife. https://doi.org/10.7554/elife.03848
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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