The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex
Open accessAbstract
Cortical responses to sensory stimuli are modulated by behavioral state. In the primary visual cortex (V1), visual responses of pyramidal neurons increase during locomotion. This response gain was suggested to be mediated through inhibitory neurons, resulting in the disinhibition of pyramidal neurons. Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive. Context-dependent locomotion responses were found in each cell type, with the highest proportion among SST neurons. These findings establish that modulation of neuronal activity by locomotion is context-dependent and contest the generality of a disinhibitory circuit for gain control of sensory responses by behavioral state.
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“In the visual cortex, the onset of arousal (as measured by pupil diameter) and locomotion increase neuronal gain32,33,36,37.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [36]
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Cites
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MethodUltrasensitive fluorescent proteins for imaging neuronal activity
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BackgroundMethodInfluentialModulation of visual responses by behavioral state in mouse visual cortex
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BackgroundResultInfluentialCortical interneurons that specialize in disinhibitory control
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BackgroundImaging large-scale neural activity with cellular resolution in awake, mobile mice
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MethodA Cortical Circuit for Gain Control by Behavioral State
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BackgroundMethodResultInfluentialPrinciples of connectivity among morphologically defined cell types in adult neocortex
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Waking state: rapid variations modulate neural and behavioral responses
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Nonlinear integration of sensory and motor inputs by a single neuron in C. elegansPreprint
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Self-citationPresubicular VIP expressing interneurons receive facilitating excitation from anterior thalamus
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BackgroundInfluentialAntipsychotic drugs selectively decorrelate long-range interactions in deep cortical layersPreprint
Heindorf, M., & Keller, G. B. (2023) · doi:10.7554/elife.86805.1 · Cited by 2
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Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layersPreprint
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Yogesh, B., & Keller, G. B. (2024) · eLife · doi:10.7554/elife.89986.3 · Cited by 2
Learning to use landmarks for navigation amplifies their representation in retrosplenial cortexPreprint
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Self-citationDisruptions in primary visual cortex physiology and function in a mouse model of Timothy syndrome
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BackgroundSex-specific resilience of neocortex to food restriction
Padamsey, Z., Katsanevaki, D., Maeso, P. A., Rizzi, M., Osterweil, E. K., & Rochefort, N. L. (2023) · eLife · doi:10.7554/elife.93052 · Cited by 2
Self-citationOpposing spatial gradients of inhibition and neural activity in mouse olfactory cortexPreprint
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BackgroundResultInfluentialNeural networks representing temporal expectation in micePreprint
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MethodSelf-citationEnvironmental context sculpts spatial and temporal visual processing in thalamusPreprint
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Lebensbedingungen haben einen starken Einfluss auf die Plastizität des Gehirns
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eLife Assessment: Sex-specific resilience of neocortex to food restriction
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Sex-specific resilience of neocortex to food restrictionPreprint
Padamsey, Z., Katsanevaki, D., Maeso, P. A., Rizzi, M., Osterweil, E. K., & Rochefort, N. L. (2023) · eLife · doi:10.7554/elife.93052.1
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Nassar, M., Richevaux, L., Lim, D., Tayupo, D., Martin, E., & Fricker, D. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4736244
Sex-specific resilience of neocortex to food restrictionPreprint
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Behavioural states control binocular vision through input-specific mechanisms
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Metadata
- Authors
- Pakan, J. M., Lowe, S. C., Dylda, E., Keemink, S. W., Currie, S. P., Coutts, C. A., & Rochefort, N. L.
- Affiliations
- University of Edinburgh (GB)
- University of Freiburg (DE)
- Corresponding author
- Rochefort, Nathalie L
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-08-23
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5030095
- OpenAlex
- W2515318112
- Cited by
- 282
- References
- 43
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 34 · 2023: 47 · 2022: 31 · 2021: 17 · 2020: 29 · 2019: 29 · 2018: 30 · 2017: 26 · 2016: 2
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Update notices
- correction (2017-09-06)
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Funders
- European Commission (Marie Curie Actions (FP7), IEF 624461, EuroSpin Erasmus Mundus Program, Marie Curie Actions (FP7), MC-CIG 631770)
- University Of Edinburgh (Doctoral Training Centre in Neuroinformatics, Graduate School of Life Sciences, Chancellor's fellow starting grant)
- Engineering and Physical Sciences Research Council (Doctoral Training Centre in Neuroinformatics, EP/F500385/1, Doctoral Training Centre in Neuroinformatics, BB/F529254/1)
- Patrick Wild Centre
- The Shirley Foundation
- RS MacDonald Charitable Trust (Seedcorn Grant 21)
- Wellcome Trust (Sir Henry Dale fellowship, 102857/Z/13/Z)
- Royal Society (Sir Henry Dale fellowship, 102857/Z/13/Z)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- primary visual cortex, locomotion, behavioral state, disinhibition, gain control, vasoactive intestinal peptide interneurons, somatostatin interneurons, parvalbumin interneurons, pyramidal neurons, inhibitory interneurons, context-dependent responses
- MeSH terms
- Animals, Behavior, Animal, Interneurons, Locomotion, Models, Neurological, Visual Cortex, Pyramidal Cells, Mice
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