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Cited by 79Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

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Erwig, Michelle S, Patzig, Julia, Steyer, Anna M, Dibaj, Payam, Heilmann, Mareike, Heilmann, Ingo, Jung, Ramona B, Kusch, Kathrin +4 more·2019·eLife
DOI 10.7554/elife.43888PMC PMC6344079
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Abstract

Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified the assembly of septin filaments in the innermost non-compacted myelin layer as one of the latest steps of myelin maturation in the central nervous system (CNS) (Patzig et al., 2016). Here we show that loss of the cytoskeletal adaptor protein anillin (ANLN) from oligodendrocytes disrupts myelin septin assembly, thereby causing the emergence of pathological myelin outfoldings. Since myelin outfoldings are a poorly understood hallmark of myelin disease and brain aging we assessed axon/myelin-units in Anln-mutant mice by focused ion beam-scanning electron microscopy (FIB-SEM); myelin outfoldings were three-dimensionally reconstructed as large sheets of multiple compact membrane layers. We suggest that anillin-dependent assembly of septin filaments scaffolds mature myelin sheaths, facilitating rapid nerve conduction in the healthy CNS.

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  • Phosphoinositides including PIP2 are abundant in CNS myelin and have been implicated in myelin protein trafficking, cytoskeletal coupling, and paranodal organization.

    “Beyond microglia, phosphoinositides including PIP2 are abundant in CNS myelin and have been implicated in myelin protein trafficking, cytoskeletal coupling, and paranodal organization [38–41]”

    From PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain (2026) · cites this paper as [39]

    The Results and discussion (page unavailable) report measuring PIP2 in purified CNS myelin and propose that PIP2–anillin interactions scaffold myelin through septin filaments, supporting the cytoskeletal-coupling part. The paper does not establish that phosphoinositides are abundant in CNS myelin, or implicate them directly in myelin protein trafficking or paranodal organization; its References list a separate study of PIP2 and myelin basic protein targeting. (LLM, conf=0.85)

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References 78 · Cited by 79

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  1. Ambrozkiewicz MC Schwark M Kishimoto-Suga M Borisova E Hori K Salazar-Lázaro A Rusanova A Altas B Piepkorn L Bessa P Schaub T Zhang X Rabe T Ripamonti S Rosário M Akiyama H Jahn O Kobayashi T Hoshino M Tarabykin V Kawabe H 2018 Polarity acquisition in cortical neurons is driven by synergistic action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140 Neuron 100 1097 1115 10.1016/j.neuron.2018.10.008 30392800 · DOI
  2. Arancibia-Cárcamo IL Ford MC Cossell L Ishida K Tohyama K Attwell D 2017 Node of ranvier length as a potential regulator of myelinated axon conduction speed eLife 6 e23329 10.7554/eLife.23329 28130923 PMC5313058 · DOI
  3. Bakhti M Snaidero N Schneider D Aggarwal S Möbius W Janshoff A Eckhardt M Nave KA Simons M 2013 Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system PNAS 110 3143 3148 10.1073/pnas.1220104110 23382229 PMC3581913 · DOI
  4. Barral Y Kinoshita M 2008 Structural insights shed light onto septin assemblies and function Current Opinion in Cell Biology 20 12 18 10.1016/j.ceb.2007.12.001 18242072 · DOI
  5. Bertin A McMurray MA Thai L Garcia G Votin V Grob P Allyn T Thorner J Nogales E 2010 Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization Journal of Molecular Biology 404 711 731 10.1016/j.jmb.2010.10.002 20951708 PMC3005623 · DOI
  6. Bizzozero OA Bixler HA Davis JD Espinosa A Messier AM 2001 Chemical deacylation reduces the adhesive properties of proteolipid protein and leads to decompaction of the myelin sheath Journal of Neurochemistry 76 1129 1141 10.1046/j.1471-4159.2001.00116.x 11181833 · DOI
  7. Bridges AA Gladfelter AS 2015 Septin form and function at the cell cortex Journal of Biological Chemistry 290 17173 17180 10.1074/jbc.R114.634444 25957401 PMC4498057 · DOI
  8. Brunner C Lassmann H Waehneldt TV Matthieu JM Linington C 1989 Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2',3'-cyclic nucleotide 3'-phosphodiesterase in the CNS of adult rats Journal of Neurochemistry 52 296 304 10.1111/j.1471-4159.1989.tb10930.x 2462020 · DOI
  9. Cardona A Saalfeld S Schindelin J Arganda-Carreras I Preibisch S Longair M Tomancak P Hartenstein V Douglas RJ 2012 TrakEM2 software for neural circuit reconstruction PLoS ONE 7 e38011 10.1371/journal.pone.0038011 22723842 PMC3378562 · DOI
  10. Cho MH Boss WF 1995 Transmembrane signaling and phosphoinositides Methods in Cell Biology 49 543 554 10.1016/S0091-679X(08)61479-X 8531783 · DOI
  11. de Monasterio-Schrader P Patzig J Möbius W Barrette B Wagner TL Kusch K Edgar JM Brophy PJ Werner HB 2013 Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2 Glia 61 1832 1847 10.1002/glia.22561 24038504 · DOI
  12. Dibaj P Zschüntzsch J Steffens H Scheffel J Göricke B Weishaupt JH Le Meur K Kirchhoff F Hanisch UK Schomburg ED Neusch C 2012 Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS PLoS ONE 7 e43963 10.1371/journal.pone.0043963 22952827 PMC3428282 · DOI
  13. Distler U Kuharev J Navarro P Levin Y Schild H Tenzer S 2014 Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics Nature Methods 11 167 170 10.1038/nmeth.2767 24336358 · DOI
  14. Distler U Kuharev J Navarro P Tenzer S 2016 Label-free quantification in ion mobility-enhanced data-independent acquisition proteomics Nature Protocols 11 795 812 10.1038/nprot.2016.042 27010757 · DOI
  15. Dolat L Hu Q Spiliotis ET 2014 Septin functions in organ system physiology and pathology Biological Chemistry 395 123 141 10.1515/hsz-2013-0233 24114910 PMC4452026 · DOI
  16. Edgar JM McLaughlin M Werner HB McCulloch MC Barrie JA Brown A Faichney AB Snaidero N Nave KA Griffiths IR 2009 Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1 Glia 57 1815 1824 10.1002/glia.20893 19459211 · DOI
  17. El Amine N Kechad A Jananji S Hickson GR 2013 Opposing actions of septins and sticky on anillin promote the transition from contractile to midbody ring The Journal of Cell Biology 203 487 504 10.1083/jcb.201305053 24217622 PMC3824009 · DOI
  18. Eluère R Varlet I Bernadac A Simon MN 2012 Cdk and the anillin homolog Bud4 define a new pathway regulating septin organization in yeast Cell Cycle 11 151 158 10.4161/cc.11.1.18542 22185758 · DOI
  19. Erb M Steck AJ Nave KA Schaeren-Wiemers N 2003 Differential expression of L- and S-MAG upon cAMP stimulated differentiation in oligodendroglial cells Journal of Neuroscience Research 71 326 337 10.1002/jnr.10497 12526022 · DOI
  20. Gallyas F 1979 Silver staining of myelin by means of physical development Neurological Research 1 203 209 10.1080/01616412.1979.11739553 95356 · DOI
  21. Ghandour MS Langley OK Vincendon G Gombos G Filippi D Limozin N Dalmasso D Laurent G 1980a Immunochemical and immunohistochemical study of carbonic anhydrase II in adult rat cerebellum: a marker for oligodendrocytes Neuroscience 5 559 571 10.1016/0306-4522(80)90053-6 6769072 · DOI
  22. Ghandour MS Vincendon G Gombos G Limozin N Filippi D Dalmasso C Laurent G 1980b Carbonic anhydrase and oligodendroglia in developing rat cerebellum: a biochemical and imunohistological study Developmental Biology 77 73 83 10.1016/0012-1606(80)90457-1 6772500 · DOI
  23. Gilden J Krummel MF 2010 Control of cortical rigidity by the cytoskeleton: emerging roles for septins Cytoskeleton 67 477 486 10.1002/cm.20461 20540086 PMC2906656 · DOI
  24. Goebbels S Oltrogge JH Kemper R Heilmann I Bormuth I Wolfer S Wichert SP Möbius W Liu X Lappe-Siefke C Rossner MJ Groszer M Suter U Frahm J Boretius S Nave KA 2010 Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination Journal of Neuroscience 30 8953 8964 10.1523/JNEUROSCI.0219-10.2010 20592216 PMC6632897 · DOI
  25. Hickson GR O'Farrell PH 2008a Anillin: a pivotal organizer of the cytokinetic machinery Biochemical Society Transactions 36 439 441 10.1042/BST0360439 18481976 PMC2695931 · DOI
  26. Hickson GR O'Farrell PH 2008b Rho-dependent control of anillin behavior during cytokinesis The Journal of Cell Biology 180 285 294 10.1083/jcb.200709005 18209105 PMC2213597 · DOI
  27. Hornung E Pernstich C Feussner I 2002 Formation of conjugated Delta11Delta13-double bonds by Delta12-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds European Journal of Biochemistry 269 4852 4859 10.1046/j.1432-1033.2002.03184.x 12354116 · DOI
  28. Jahn O Tenzer S Werner HB 2009 Myelin proteomics: molecular anatomy of an insulating sheath Molecular Neurobiology 40 55 72 10.1007/s12035-009-8071-2 19452287 PMC2758371 · DOI
  29. Jahn O Tenzer S Bartsch N Patzig J Werner HB 2013 Myelin proteome analysis: methods and implications for the myelin cytoskeleton Neuromethods 79 335 353 10.1007/978-1-62703-266-7_15 · DOI
  30. Jung M Sommer I Schachner M Nave KA 1996 Monoclonal antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): evidence that PLP misfolding underlies dysmyelination in mutant mice The Journal of Neuroscience 16 7920 7929 10.1523/JNEUROSCI.16-24-07920.1996 8987820 PMC6579218 · DOI
  31. Kammers K Cole RN Tiengwe C Ruczinski I 2015 Detecting significant changes in protein abundance EuPA Open Proteomics 7 11 19 10.1016/j.euprot.2015.02.002 25821719 PMC4373093 · DOI
  32. Kang PJ Hood-DeGrenier JK Park HO 2013 Coupling of septins to the axial landmark by Bud4 in budding yeast Journal of Cell Science 126 1218 1226 10.1242/jcs.118521 23345395 PMC3635463 · DOI
  33. König S Hoffmann M Mosblech A Heilmann I 2008 Determination of content and fatty acid composition of unlabeled phosphoinositide species by thin-layer chromatography and gas chromatography Analytical Biochemistry 378 197 201 10.1016/j.ab.2008.03.052 18466755 · DOI
  34. Kremer JR Mastronarde DN McIntosh JR 1996 Computer visualization of three-dimensional image data using IMOD Journal of Structural Biology 116 71 76 10.1006/jsbi.1996.0013 8742726 · DOI
  35. Kuharev J Navarro P Distler U Jahn O Tenzer S 2015 In-depth evaluation of software tools for data-independent acquisition based label-free quantification Proteomics 15 3140 3151 10.1002/pmic.201400396 25545627 · DOI
  36. Lappe-Siefke C Goebbels S Gravel M Nicksch E Lee J Braun PE Griffiths IR Nave KA 2003 Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination Nature Genetics 33 366 374 10.1038/ng1095 12590258 · DOI · Paper page
  37. Lasiene J Matsui A Sawa Y Wong F Horner PJ 2009 Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes Aging Cell 8 201 213 10.1111/j.1474-9726.2009.00462.x 19338498 PMC2703583 · DOI · Paper page
  38. Lein ES Hawrylycz MJ Ao N Ayres M Bensinger A Bernard A Boe AF Boguski MS Brockway KS Byrnes EJ Chen L Chen L Chen TM Chin MC Chong J Crook BE Czaplinska A Dang CN Datta S Dee NR Desaki AL Desta T Diep E Dolbeare TA Donelan MJ Dong HW Dougherty JG Duncan BJ Ebbert AJ Eichele G Estin LK Faber C Facer BA Fields R Fischer SR Fliss TP Frensley C Gates SN Glattfelder KJ Halverson KR Hart MR Hohmann JG Howell MP Jeung DP Johnson RA Karr PT Kawal R Kidney JM Knapik RH Kuan CL Lake JH Laramee AR Larsen KD Lau C Lemon TA Liang AJ Liu Y Luong LT Michaels J Morgan JJ Morgan RJ Mortrud MT Mosqueda NF Ng LL Ng R Orta GJ Overly CC Pak TH Parry SE Pathak SD Pearson OC Puchalski RB Riley ZL Rockett HR Rowland SA Royall JJ Ruiz MJ Sarno NR Schaffnit K Shapovalova NV Sivisay T Slaughterbeck CR Smith SC Smith KA Smith BI Sodt AJ Stewart NN Stumpf KR Sunkin SM Sutram M Tam A Teemer CD Thaller C Thompson CL Varnam LR Visel A Whitlock RM Wohnoutka PE Wolkey CK Wong VY Wood M Yaylaoglu MB Young RC Youngstrom BL Yuan XF Zhang B Zwingman TA Jones AR 2007 Genome-wide atlas of gene expression in the adult mouse brain Nature 445 168 176 10.1038/nature05453 17151600 · DOI · Paper page
  39. Linnington C Webb M Woodhams PL 1984 A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody Journal of Neuroimmunology 6 387 396 10.1016/0165-5728(84)90064-X 6207204 · DOI
  40. Liu J Fairn GD Ceccarelli DF Sicheri F Wilde A 2012 Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin Current Biology 22 64 69 10.1016/j.cub.2011.11.040 22197245 · DOI
  41. Lüders KA Patzig J Simons M Nave KA Werner HB 2017 Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2 Glia 65 1762 1776 10.1002/glia.23193 28836307 · DOI
  42. Lüders KA Nessler S Kusch K Patzig J Jung RB Möbius W Nave KA Werner HB 2019 Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons Glia 10.1002/glia.23549 30637801 · DOI
  43. Möbius W Cooper B Kaufmann WA Imig C Ruhwedel T Snaidero N Saab AS Varoqueaux F 2010 Electron microscopy of the mouse central nervous system Methods in Cell Biology 96 475 512 10.1016/S0091-679X(10)96020-2 20869535 · DOI
  44. Möbius W Nave KA Werner HB 2016 Electron microscopy of myelin: structure preservation by high-pressure freezing Brain Research 1641 92 100 10.1016/j.brainres.2016.02.027 26920467 · DOI
  45. Müller C Bauer NM Schäfer I White R 2013 Making myelin basic protein -from mRNA transport to localized translation Frontiers in Cellular Neuroscience 7 169 10.3389/fncel.2013.00169 24098271 PMC3784684 · DOI
  46. Musse AA Gao W Homchaudhuri L Boggs JM Harauz G 2008 Myelin basic protein as a "PI(4,5)P2-modulin": a new biological function for a major central nervous system protein Biochemistry 47 10372 10382 10.1021/bi801302b 18767817 · DOI
  47. Nave KA Werner HB 2014 Myelination of the nervous system: mechanisms and functions Annual Review of Cell and Developmental Biology 30 503 533 10.1146/annurev-cellbio-100913-013101 25288117 · DOI
  48. Nawaz S Kippert A Saab A Werner HB Lang T Nave KA Simons M 2009 Phosphatidylinositol (4,5) bisphosphate regulates membrane targeting of myelin basic protein Journal of Neuroscience 29 4794 4807 10.1523/JNEUROSCI.3955-08 19369548 PMC6665343 · DOI
  49. Nawaz S Schweitzer J Jahn O Werner HB 2013 Molecular evolution of myelin basic protein, an abundant structural myelin component Glia 61 1364 1377 10.1002/glia.22520 24040667 · DOI
  50. Nawaz S Sánchez P Schmitt S Snaidero N Mitkovski M Velte C Brückner BR Alexopoulos I Czopka T Jung SY Rhee JS Janshoff A Witke W Schaap IAT Lyons DA Simons M 2015 Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system Developmental Cell 34 139 151 10.1016/j.devcel.2015.05.013 26166299 PMC4736019 · DOI
  51. Patzig J Erwig MS Tenzer S Kusch K Dibaj P Möbius W Goebbels S Schaeren-Wiemers N Nave KA Werner HB 2016a Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction eLife 5 e17119 10.7554/eLife.17119 27504968 PMC4978525 · DOI
  52. Patzig J Kusch K Fledrich R Eichel MA Lüders KA Möbius W Sereda MW Nave KA Martini R Werner HB 2016b Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking Glia 64 155 174 10.1002/glia.22922 26393339 · DOI
  53. Perera IY Davis AJ Galanopoulou D Im YJ Boss WF 2005 Characterization and comparative analysis of arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in arabidopsis and human phosphatidylinositol phosphate kinases FEBS Letters 579 3427 3432 10.1016/j.febslet.2005.05.018 15949803 · DOI
  54. Peters A 2002 The effects of normal aging on myelin and nerve fibers: a review Journal of Neurocytology 31 581 593 10.1023/A:1025731309829 14501200 · DOI · Paper page
  55. Piekny AJ Maddox AS 2010 The myriad roles of anillin during cytokinesis Seminars in Cell & Developmental Biology 21 881 891 10.1016/j.semcdb.2010.08.002 20732437 · DOI
  56. Rosenbluth J Nave KA Mierzwa A Schiff R 2006 Subtle myelin defects in PLP-null mice Glia 54 172 182 10.1002/glia.20370 16802387 · DOI
  57. Schardt A Brinkmann BG Mitkovski M Sereda MW Werner HB Nave KA 2009 The SNARE protein SNAP-29 interacts with the GTPase Rab3A: implications for membrane trafficking in myelinating glia Journal of Neuroscience Research 87 3465 3479 10.1002/jnr.22005 19170188 · DOI
  58. Schindelin J Arganda-Carreras I Frise E Kaynig V Longair M Pietzsch T Preibisch S Rueden C Saalfeld S Schmid B Tinevez JY White DJ Hartenstein V Eliceiri K Tomancak P Cardona A 2012 Fiji: an open-source platform for biological-image analysis Nature Methods 9 676 682 10.1038/nmeth.2019 22743772 PMC3855844 · DOI · Paper page
  59. Silva JC Denny R Dorschel C Gorenstein MV Li GZ Richardson K Wall D Geromanos SJ 2006 Simultaneous qualitative and quantitative analysis of the Escherichia coli proteome: a sweet tale Molecular & Cellular Proteomics: MCP 5 589 607 10.1074/mcp.M500321-MCP200 16399765 · DOI
  60. Snaidero N Simons M 2017 The logistics of myelin biogenesis in the central nervous system Glia 65 1021 1031 10.1002/glia.23116 28168748 · DOI
  61. Snaidero N Velte C Myllykoski M Raasakka A Ignatev A Werner HB Erwig MS Möbius W Kursula P Nave KA Simons M 2017 Antagonistic functions of MBP and CNP establish cytosolic channels in CNS myelin Cell Reports 18 314 323 10.1016/j.celrep.2016.12.053 28076777 PMC5263235 · DOI
  62. Sturrock RR 1976 Changes in neurologia and myelination in the white matter of aging mice Journal of Gerontology 31 513 522 10.1093/geronj/31.5.513 950445 · DOI
  63. Tasto JJ Morrell JL Gould KL 2003 An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation The Journal of Cell Biology 160 1093 1103 10.1083/jcb.200211126 12668659 PMC2172762 · DOI
  64. Thakurela S Garding A Jung RB Müller C Goebbels S White R Werner HB Tiwari VK 2016 The transcriptome of mouse central nervous system myelin Scientific Reports 6 25828 10.1038/srep25828 27173133 PMC4865983 · DOI
  65. Trapp BD Bernier L Andrews SB Colman DR 1988 Cellular and subcellular distribution of 2',3'-cyclic nucleotide 3'-phosphodiesterase and its mRNA in the rat central nervous system Journal of Neurochemistry 51 859 868 10.1111/j.1471-4159.1988.tb01822.x 2842456 · DOI
  66. Werner HB Krämer-Albers EM Strenzke N Saher G Tenzer S Ohno-Iwashita Y De Monasterio-Schrader P Möbius W Moser T Griffiths IR Nave KA 2013 A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system Glia 61 567 586 10.1002/glia.22456 23322581 · DOI
  67. Zeisel A Muñoz-Manchado AB Codeluppi S Lönnerberg P La Manno G Juréus A Marques S Munguba H He L Betsholtz C Rolny C Castelo-Branco G Hjerling-Leffler J Linnarsson S 2015 Brain structure. cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq Science 347 1138 1142 10.1126/science.aaa1934 25700174 · DOI · Paper page
  68. Zhang L Maddox AS 2010 Anillin Current Biology 20 R135 R136 10.1016/j.cub.2009.12.017 20178751 · DOI
  69. Zuchero JB Fu MM Sloan SA Ibrahim A Olson A Zaremba A Dugas JC Wienbar S Caprariello AV Kantor C Leonoudakis D Leonoudakus D Lariosa-Willingham K Kronenberg G Gertz K Soderling SH Miller RH Barres BA 2015 CNS myelin wrapping is driven by actin disassembly Developmental Cell 34 152 167 10.1016/j.devcel.2015.06.011 26166300 PMC4519368 · DOI · Paper page

Authors
Erwig, M. S., Patzig, J., Steyer, A. M., Dibaj, P., Heilmann, M., Heilmann, I., Jung, R. B., Kusch, K., Möbius, W., Jahn, O., Nave, K.-A., & Werner, H. B.
Affiliations
  • Max Planck Institute of Experimental Medicine (DE)
  • Martin Luther University Halle-Wittenberg (DE)
  • Boston Children's Hospital (US)
Corresponding author
Werner, Hauke B
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2019-01-23
Volume
8
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.43888
PMC
PMC6344079
OpenAlex
W2911921088
Cited by
79
References
78
Citations by year
2026: 9 · 2025: 7 · 2024: 15 · 2023: 7 · 2022: 13 · 2021: 12 · 2020: 14 · 2019: 2
FWCI
3.85
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, other-oa)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
  • MPG.PuRe (Max Planck Society) (submittedVersion, cc-by)
Funders
  • Deutsche Forschungsgemeinschaft (WE2720/2-2, WE2720/4-1)
  • European Research Council (Advanced Grant MyeliNano)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
anillin, oligodendrocytes, central nervous system myelin, nerve conduction, myelin diseases, brain aging
MeSH terms
Animals, Central Nervous System, Contractile Proteins, Myelin Sheath, Protein Folding, Mice, Septins

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