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Cited by 111Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes

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Lasiene, Jurate, Matsui, Aya, Sawa, Yuhito, Wong, Fernando, Horner, Philip J.·2009·Aging Cell
DOI 10.1111/j.1474-9726.2009.00462.xPMC PMC2703583
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Abstract

Aging is associated with many functional and morphological central nervous system changes. It is important to distinguish between changes created by normal aging and those caused by disease. In the present study we characterized myelin changes within the murine rubrospinal tract and found that internode lengths significantly decrease as a function of age which suggests active remyelination. We also analyzed the proliferation, distribution and phenotypic fate of dividing cells with Bromodeoxyuridine (5-bromo-2-deoxyuridine, BrdU). The data reveal a decrease in glial cell proliferation from 1 to 6, 14 and 21 months of age in gray matter 4 weeks post-BrdU injections. However, we found an increase in gliogenesis at 21st month in white matter of the spinal cord. Half of newly generated cells expressed NG2. Most cells were positive for the early oligodendrocyte marker Olig2 and a few also expressed CC1. Very few cells ever became positive for the astrocytic markers S100beta or GFAP. These data demonstrate ongoing oligodendrogenesis and myelinogenesis as a function of age in the spinal cord.

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  • Simulations published by Lasiene et al. (2009), assuming the existence of a periaxonal space, predicted that shorter internodes should decrease conduction speed.

    “Consistent with this, simulations published by Lasiene et al. (2009), assuming the existence of a periaxonal space, predicted that shorter internodes should decrease conduction speed.”

    From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Lasiene et al. (2009)

    The Discussion says that shorter internodes can change conduction speed and signal timing. It does not say the change is a decrease, and the paper’s internode measurements are not simulations; the searched passages also do not describe an assumed periaxonal space. The claim therefore attributes a more specific prediction and method to this paper than our copy supports. (LLM, conf=0.85)

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  • Our data are consistent with the observations that abnormally short myelin internodes accumulate with age in mouse spinal cord white matter and that paranode frequency increases with age in the rhesus monkey brain.

    “Our data are consistent with the observations that abnormally short myelin internodes accumulate with age in mouse spinal cord white matter (Lasiene et al., 2009) and that paranode frequency increases with age in the rhesus monkey brain (reviewed by Peters and Kemper, 2012).”

    From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Lasiene et al., 2009

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Authors
Lasiene, J., Matsui, A., Sawa, Y., Wong, F., & Horner, P. J.
Affiliations
  • University of Washington (US)
  • Oregon Health & Science University (US)
Corresponding author
Horner, Philip J.
ORCID
Venue
Aging Cell
Publisher
Wiley
Published
2009-03-26
Volume
8
Issue
2
Pages
201-213
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
DOI
10.1111/j.1474-9726.2009.00462.x
PMC
PMC2703583
OpenAlex
W1966017102
Cited by
111
References
58
Citations by year
2026: 3 · 2025: 9 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 3 · 2016: 13 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 1
FWCI
1.36
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Aging Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • International Foundation for Research in Paraplegia
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R01 NS46724, R01NS046724)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
aging, myelination, oligodendrogenesis, remyelination, internode length, rubrospinal tract, spinal cord, glial cell proliferation, oligodendrocyte precursor cells, Olig2, gray matter, white matter, astrocytes, BrdU labeling
MeSH terms
Autophagy-Related Proteins, Oligodendrocyte Transcription Factor 2, Aging, Animals, Bromodeoxyuridine, Efferent Pathways, Female, Mice, Inbred C57BL, Myelin Sheath, Nerve Fibers, Myelinated, Nerve Regeneration, Nerve Tissue Proteins, Oligodendroglia, Ranvier's Nodes, Red Nucleus, Spinal Cord, Biomarkers, Intracellular Signaling Peptides and Proteins, Cell Proliferation, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins

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