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Cited by 156Memory and Neural MechanismsMemory Processes and InfluencesNeural dynamics and brain function

Cortico-hippocampal network connections support the multidimensional quality of episodic memory

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Cooper, Rose A, Ritchey, Maureen·2019·eLife
DOI 10.7554/elife.45591PMC PMC6450667

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Abstract

Episodic memories reflect a bound representation of multimodal features that can be reinstated with varying precision. Yet little is known about how brain networks involved in memory, including the hippocampus and posterior-medial (PM) and anterior-temporal (AT) systems, interact to support the quality and content of recollection. Participants learned color, spatial, and emotion associations of objects, later reconstructing the visual features using a continuous color spectrum and 360-degree panorama scenes. Behaviorally, dependencies in memory were observed for the gist but not precision of event associations. Supporting this integration, hippocampus, AT, and PM regions showed increased connectivity and reduced modularity during retrieval compared to encoding. These inter-network connections tracked a multidimensional, objective measure of memory quality. Moreover, distinct patterns of connectivity tracked item color and spatial memory precision. These findings demonstrate how hippocampal-cortical connections reconfigure during episodic retrieval, and how such dynamic interactions might flexibly support the multidimensional quality of remembered events.

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  • Episodic memory relies on interactions between the hippocampus and its interconnected cortical circuits, with the PCC, RSC, mPFC, and left AG nodes of the DMN featuring prominently.

    “Episodic memory relies on interactions between the hippocampus and its interconnected cortical circuits, with the PCC, RSC, mPFC, and left AG nodes of the DMN featuring prominently.”

    From 20 years of the default mode network: A review and synthesis. (2023) · cites this paper as [49]

    The Discussion reports increased communication between the hippocampus and cortical systems during episodic retrieval, and the Methods identify PCC, RSC, and angular gyrus as regions studied. But the paper analyzes bilateral angular gyrus, not specifically left AG, and does not identify mPFC among its studied regions or characterize the listed regions collectively as DMN nodes. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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References 86 · Cited by 156

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Authors
Cooper, R. A., & Ritchey, M.
Affiliations
Boston College (US)
Corresponding author
Cooper, Rose A
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2019-03-22
Volume
8
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.45591
PMC
PMC6450667
OpenAlex
W2913614819
Cited by
156
References
86
Citations by year
2026: 20 · 2025: 20 · 2024: 21 · 2023: 24 · 2022: 25 · 2021: 29 · 2020: 9 · 2019: 8
FWCI
10.32
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R00MH103401)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
episodic memory, memory quality, recollection, hippocampus, posterior medial cortex, anterior temporal cortex, network modularity, memory precision, color memory, spatial memory, emotional memory, memory retrieval, memory encoding
MeSH terms
Adolescent, Adult, Brain Mapping, Cerebral Cortex, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Young Adult, Memory, Episodic

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