Cited by 1,138Memory and Neural MechanismsMemory Processes and InfluencesCognitive Functions and Memory

Item, context and relational episodic encoding in humans

Davachi, Lila·2006·Current Opinion in Neurobiology

Abstract

Recent functional imaging work supports the view that item and relational memory depend upon distinct encoding operations within the medial temporal lobe. Specifically, emerging findings demonstrate that the level of engagement of perirhinal cortex predicts later memory for individual items, whereas the level of hippocampal processing correlates with later relational memory, or recovery of additional episodic details. Furthermore, recent functional magnetic resonance imaging evidence in humans suggests that medial temporal lobe cortical input structures, the perirhinal and posterior parahippocampal cortices, differentially participate in the encoding of objects and their context, providing domain-specific input to the hippocampus. Taken together, these data help to construct a working model of how distinct medial temporal lobe structures participate in episodic memory formation with domain-general relational binding mechanisms supported by the hippocampus and provide emerging evidence for domain-specificity within the perirhinal and parahippocampal cortices.

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Crossref · 10.1016/j.conb.2006.10.012

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Authors
Davachi, L.
Affiliations
New York University (US)
Corresponding author
Davachi, Lila
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2006-12
Volume
16
Issue
6
Pages
693-700
ISSN
0959-4388 (ISSN-L)
OpenAlex
W1966647730
Cited by
1,138
References
63
Citations by year
2026: 30 · 2025: 53 · 2024: 49 · 2023: 50 · 2022: 52 · 2021: 55 · 2020: 76 · 2019: 72 · 2018: 78 · 2017: 86 · 2016: 72 · 2015: 74 · 2014: 66 · 2013: 70 · 2012: 64
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
episodic memory encoding, item memory, relational memory, perirhinal cortex, hippocampus, medial temporal lobe, contextual memory, domain specificity, relational binding, object memory
MeSH terms
Brain Mapping, Hippocampus, Humans, Functional Laterality, Learning, Magnetic Resonance Imaging, Memory, Neural Pathways, Perception, Parahippocampal Gyrus

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