Item, context and relational episodic encoding in humans
Abstract
Recent functional imaging work supports the view that item and relational memory depend upon distinct encoding operations within the medial temporal lobe. Specifically, emerging findings demonstrate that the level of engagement of perirhinal cortex predicts later memory for individual items, whereas the level of hippocampal processing correlates with later relational memory, or recovery of additional episodic details. Furthermore, recent functional magnetic resonance imaging evidence in humans suggests that medial temporal lobe cortical input structures, the perirhinal and posterior parahippocampal cortices, differentially participate in the encoding of objects and their context, providing domain-specific input to the hippocampus. Taken together, these data help to construct a working model of how distinct medial temporal lobe structures participate in episodic memory formation with domain-general relational binding mechanisms supported by the hippocampus and provide emerging evidence for domain-specificity within the perirhinal and parahippocampal cortices.
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The PHC has been implicated in memory for specific context information.
“the PHC has been implicated in memory for specific context information”
From Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval (2015) · cites this paper as Davachi, 2006
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Self-citation
- Authors
- Davachi, L.
- Affiliations
- New York University (US)
- Corresponding author
- Davachi, Lila
- ORCID
- Davachi, Lila
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 16
- Issue
- 6
- Pages
- 693-700
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W1966647730
- Cited by
- 1,138
- References
- 63
- Citations by year
- 2026: 30 · 2025: 53 · 2024: 49 · 2023: 50 · 2022: 52 · 2021: 55 · 2020: 76 · 2019: 72 · 2018: 78 · 2017: 86 · 2016: 72 · 2015: 74 · 2014: 66 · 2013: 70 · 2012: 64
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- episodic memory encoding, item memory, relational memory, perirhinal cortex, hippocampus, medial temporal lobe, contextual memory, domain specificity, relational binding, object memory
- MeSH terms
- Brain Mapping, Hippocampus, Humans, Functional Laterality, Learning, Magnetic Resonance Imaging, Memory, Neural Pathways, Perception, Parahippocampal Gyrus
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