The DOI matches its Crossref record; 68 of the 70 references it cites were found in a registry or an index.
Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
Open accessAbstract
Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer’s disease (AD) is hypothesized to involve amyloid-β (Aβ) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC and posteromedial EC (pmEC), subregions of EC that differ in functional specialization and cortical connectivity, with the hypothesis that alEC-connected cortex would show greater tau deposition than pmEC-connected cortex. We used resting state fMRI to measure FC, and PET to measure tau and Aβ in cognitively normal older adults. Tau preferentially deposited in alEC-connected cortex compared to pmEC-connected or non-connected cortex, and stronger connectivity was associated with increased tau deposition. FC-tau relationships were present regardless of Aβ, although strengthened with Aβ. These results provide an explanation for the anatomic specificity of neocortical tau deposition in the aging brain and reveal relationships between normal aging and the evolution of AD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The vulnerability of the entorhinal neurons has been reported in many previous studies (Adams et al., 2019, Rodriguez et al., 2019, Braak and Del Tredici, 2020).”
From Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis (2020) · cites this paper as Adams et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700
Conn : A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks
Whitfield-Gabrieli, S., & Nieto-Castanon, A. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0073 · Cited by 4,885
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
Self-citationA component based noise correction method (CompCor) for BOLD and perfusion based fMRI
Behzadi, Y., Restom, K., Liau, J., & Liu, T. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.042 · Cited by 4,502
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427
Flagged first, then by citations
2 of the 70 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–160 of 160
Feng, J., Liao, L., Xu, F., Zhang, L., & Zhang, J. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6847917 · Cited by 6
Denkinger, M. N., Baker, S. L., Harrison, T. M., Chadwick, T. A., & Jagust, W. J. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.11.002 · Cited by 4
Self-citationTau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths
Maboudian, S. A., Fonseca, C. S., Martersteck, A., Chao, Y., Chen, Y., Ushizima, D. M., Tosun, D., Grinberg, L. T., Weiner, K. S., Jagust, W. J., et al. (2026) · Annals of Neurology · doi:10.1002/ana.78166 · Cited by 4
Self-citationPotential Protective Function of Aβ42 Monomer on Tauopathies
Gray, A. L. H., Norman, V., Oluwatoba, D. S., Prosser, R. A., & Do, T. D. (2023) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.2c00343 · Cited by 4
Zinkunegi, A. J., Betthauser, T. J., Carlsson, C. M., Bendlin, B. B., Okonkwo, O. C., Chin, N. A., Asthana, S., Langhough, R. E., Johnson, S. C., Mueller, K. D., et al. (2025) · Cortex · doi:10.1016/j.cortex.2024.12.012 · Cited by 4
Fischer, L., Adams, J. N., Molloy, E. N., Tremblay‐Mercier, J., Remz, J., Binette, A. P., Rajah, M. N., Villeneuve, S., Maaß, A., Poirier, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-21596-0 · Cited by 4
Self-citationSpatial patterns of tau accumulation across the Alzheimer's disease spectrum
Fonseca, C. S., Chao, Y., Joie, R. L., Rabinovici, G. D., Jagust, W. J., Harrison, T. M., & Initiative, A. D. N. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71076 · Cited by 3
Self-citationArmstrong, C., Luo, D., Gretzinger, A., Pandey, D., Lipchik, A. M., Todi, S. V., & Dutta, A. K. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00220 · Cited by 3
Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration
Rodríguez-Carreiro, S., Nogales, M. D. C., Jiménez-Galán, D., Carmona-Lorenzo, S., Caro-Martín, A., Navarro, E., & Esteras, N. (2024) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-24-00005 · Cited by 2
Gupta, A., Ghosh, A., Sharma, N., & Gorain, B. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05003-3 · Cited by 4
Rosenich, E., & Lim, Y. Y. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01776-w · Cited by 3
Datta, D. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad134 · Cited by 3
Teng, J., McKenna, M. R., Gbadeyan, O., Prakash, R. S., & Initiative, A. D. N. (2024) · Network Neuroscience · doi:10.1162/netn_a_00373 · Cited by 6
Behaviorally meaningful functional networks mediate the effect of Alzheimer’s pathology on cognition
Ziontz, J., Harrison, T. M., Chen, X., Giorgio, J., Adams, J. N., Wang, Z., Jagust, W. J., & Initiative, A. D. N. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae134 · Cited by 3
Self-citationWeir, J. S., Hanssen, K. S., Winter‐Hjelm, N., Sandvig, A., & Sandvig, I. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16625 · Cited by 3
Huang, Y., Xie, X., Chen, R., Huang, Z., Gangal, H., Wang, X., & Wang, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.15.670607 · Cited by 3
Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis
Al-Amin, M. M., Grandjean, J., Klohs, J., & Kim, J. (2020) · doi:10.1101/2020.04.27.064634 · Cited by 2
“The vulnerability of the entorhinal neurons has been reported in many previous studies (Adams et al., 2019, Rodriguez et al., 2019, Braak and Del Tredici, 2020).”
MethodOlfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer's disease
Bouchoucha, K., Collin, L., Coquette, C., Colmant, L., Boyer, E., Huyghe, L., Quenon, L., Gérard, T., Salman, Y., Hox, V., et al. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.71402 · Cited by 1
Shao, K., Chen, X., Yu, X., Yang, J., Wei, M., Zhang, M., Li, R., Wang, X., Wei, Y., Yan, C., et al. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241291236 · Cited by 2
Declaration of Competing Interest
Cui, W., & Xiang, L. (2024) · Wiley eBooks · doi:10.1002/9783527845583.oth1 · Cited by 3
Aβ remotely and locally facilitates Alzheimer’s disease tau spreading
Nabizadeh, F., Initiative, A. D. N., & Nabizadeh, F. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae386 · Cited by 1
The Psychopathology and Neuropsychology of Alzheimer’s Disease: A New Narrative
Barakat, M., Annan, I., Sader, A., & Khoury, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_54-1 · Cited by 1
Xu, X., Mo, X., Zhang, W., Liu, D., Chen, Q., Lu, J., Zhu, Y., Chen, J., Zhang, B., Zhu, Z., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251322539 · Cited by 1
Object fine-grained discrimination as a sensitive cognitive marker of transentorhinal integrity
Delhaye, E., Besson, G., Bahri, M. A., & Bastin, C. (2025) · Communications Biology · doi:10.1038/s42003-025-08201-w · Cited by 1
Malarte, M., Chiotis, K., Ioannou, K., & Rodriguez‐Vieitez, E. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70222 · Cited by 2
Glaubitz, E., Wang, X. H., Xi, K., Feiz, F., Pahlajani, S. S., Maloney, T., Tanzi, E. B., Hojjati, H., Zhou, L., Glodzik, L., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115889 · Cited by 2
Gabani, Z. Y., Singh, J., Hamlett, E. D., Granholm, A., & Margittai, M. (2026) · JACS Au · doi:10.1021/jacsau.5c01693 · Cited by 2
Huang, Y. S., Xie, X., Huang, Z., Gangal, H., Chen, R., Wang, X., Li, J., & Wang, J. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111069 · Cited by 5
Kanter, B. R., Moser, E. I., & Witter, M. P. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0012 · Cited by 1
Contemporary Trends in MRI and PET Imaging for the Early Diagnosis of Alzheimer’s Disease
Chan, B. (2022) · International journal of high school research · doi:10.36838/v4i6.2 · Cited by 1
Ziontz, J., Adams, J. N., Harrison, T. M., Baker, S. L., & Jagust, W. J. (2021) · doi:10.21203/rs.3.rs-235539/v1 · Cited by 1
Self-citation3E09-2 ガソリン添加剤、MTBEおよびETBEの微生物分解(環境浄化・修復・保全技術,一般講演)
阪井, 康., 斎藤, 佑., 小谷, 哲., 由里本, 博., 鈴木, 源., 盛満, 耕., & 加藤, 暢. (2004) · 日本生物工学会大会講演要旨集
Rodriguez-Rodriguez, P., Arroyo-García, L., Li, L.-C., Tsagkogianni, C., Wang, W., Salas-Allende, I., Plautz, Z. R., Cedazo-Mínguez, A., Sinha, S. C., Troyanskaya, O., et al. (2022) · bioRxiv · doi:10.1101/2022.05.14.491965
Blujus, J. K., Cole, M. W., Festa, E. K., Buka, S. L., Salloway, S., Heindel, W. C., Oh, H., & Initiative, T. A. D. N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.18.496543
Ananth, M. R., Gardus, J. D., Huang, C., Palekar, N., Slifstein, M., Záborszky, L., Parsey, R. V., Talmage, D. A., DeLorenzo, C., & Role, L. W. (2024) · Research Square · doi:10.21203/rs.3.rs-3851086/v1
Carbonell, F., McNicoll, C., Zijdenbos, A. P., Bedell, B. J., & Initiative, A. D. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.23.576866
Ananth, M. R., Gardus, J. D., Huang, C., Palekar, N., Slifstein, M., Záborszky, L., Parsey, R. V., Talmage, D. A., DeLorenzo, C., & Role, L. W. (2024) · Research Square · doi:10.21203/rs.3.rs-3851086/v2
Dominguez, P. A., Palpatzis, E., Akinci, M., Canal-García, A., Pereira, J. B., Bejanin, A., & Arenaza‐Urquijo, E. M. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100294
The Psychopathology and Neuropsychology of Alzheimer’s Disease: A New Narrative
Barakat, M., Annan, I., Sader, A., & Khoury, R. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_54
Wherever tau pathology starts, propagation will follow brain connections
Malotaux, V., Salman, Y., & Hanseeuw, B. J. (2025) · Brain · doi:10.1093/brain/awaf350
Apolipoprotein E gene allele 4 and amyloid-beta mediate tau-related network breakdown
Nabizadeh, F. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf404
A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus
Ash, A. M., Baek, S. R., Holder, P., Singh, S., Vyleta, N. P., Willman, M., Nash, K. R., & Snyder, J. S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323230 · Cited by 1
Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J., Wang, S. J., Lin, F.-C., Scott, W. K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20454493
Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J., Wang, S. J., Lin, F.-C., Scott, W. K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20454505
Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J., Wang, S. J., Lin, F.-C., Scott, W. K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20454499
Sanchez, J. S., Hanseeuw, B. J., Lopera, F., Sperling, R. A., Baena, A. Y., Bocanegra, Y., Aguillon, D., Guzmán‐Vélez, E., Pardilla‐Delgado, E., Ramirez-Gomez, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13585302
Sanchez, J. S., Hanseeuw, B. J., Lopera, F., Sperling, R. A., Baena, A. Y., Bocanegra, Y., Aguillon, D., Guzmán‐Vélez, E., Pardilla‐Delgado, E., Ramirez-Gomez, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13585296
Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J., Wang, S. J., Lin, F.-C., Scott, W. K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20454502
Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J., Wang, S. J., Lin, F.-C., Scott, W. K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20454496
Sanchez, J. S., Hanseeuw, B. J., Lopera, F., Sperling, R. A., Baena, A. Y., Bocanegra, Y., Aguillon, D., Guzmán‐Vélez, E., Pardilla‐Delgado, E., Ramirez-Gomez, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13585305
Sanchez, J. S., Hanseeuw, B. J., Lopera, F., Sperling, R. A., Baena, A. Y., Bocanegra, Y., Aguillon, D., Guzmán‐Vélez, E., Pardilla‐Delgado, E., Ramirez-Gomez, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13585308
Sanchez, J. S., Hanseeuw, B. J., Lopera, F., Sperling, R. A., Baena, A. Y., Bocanegra, Y., Aguillon, D., Guzmán‐Vélez, E., Pardilla‐Delgado, E., Ramirez-Gomez, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13585299
Prospect in Alzheimer’s disease integrative therapy targeting both amyloid-beta and tau
Zhang, W., Zhou, Y., Chen, J., Pérez, M., Claure, X., & Leblanc, R. M. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00916 · Cited by 1
Neurobiological links between Alzheimer’s disease and reward system dysfunction
Harutyunyan, H. S., Minasyan, R., Kalueff, A. V., & Yenkoyan, K. B. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.03.028
Dautricourt, S. (2021) · theses.fr (ABES) · doi:10.70675/63472a25z31eaz4ebczaebdzd8d2e061b4b8
de Bruin, H., Groot, C., Zhu, Z., van de Giessen, E., Shcherbinin, S., Kotari, V., Svaldi, D. O., Pijnenburg, Y. A. L., Coomans, E. M., Ossenkoppele, R., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71718
50µm ex vivo MRI reveals distant layer-specific hippocampal atrophy in early Alzheimer's diseasePreprint
Salman, Y., Tomé, S. O., Joudiou, N., Annettesdotter, A., Khandelwal, P., Lawson, T. M., Behets, C., Lengelé, B., Thal, D. R., Yushkevich, P. A., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10800434/v1
Measuring in-vivo tau pathology in the basal forebrain with PET imaging
Harrison, T. M., Chadwick, T. A., Grothe, M. J., Ward, T., Baker, S. L., Landau, S. M., Jagust, W. J., & Initiative, A. D. N. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02564-2
Self-citationThe relation of whole-brain functional connectivity to global amyloid and local tau presence
Ziadlou, D., Wales, R., Chen, X., & Leung, H.-C. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.10.007
Metadata
- Authors
- Adams, J. N., Maass, A., Harrison, T. M., Baker, S. L., & Jagust, W. J.
- Affiliations
- University of California, Berkeley (US)
- German Center for Neurodegenerative Diseases (DE)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Adams, Jenna N
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2019-09-02
- Volume
- 8
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC6764824
- OpenAlex
- W2971637931
- Cited by
- 160
- References
- 70
- Citations by year
- 2026: 10 · 2025: 29 · 2024: 30 · 2023: 20 · 2022: 27 · 2021: 34 · 2020: 8 · 2019: 1
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R01-AG034570, F32-AG057107)
- Helmholtz-Gemeinschaft (Postdoc Program PD-306)
- Tau Consortium
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- tau deposition, entorhinal cortex, functional connectivity, brain aging, Alzheimer's disease, amyloid-beta, transentorhinal cortex, resting-state fMRI, positron emission tomography, cognitive aging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Amyloid beta-Peptides, tau Proteins, Entorhinal Cortex, Positron-Emission Tomography, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
