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Cited by 109Gastroesophageal reflux and treatmentsGastrointestinal motility and disordersEsophageal and GI Pathology

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Gastroesophageal reflux in children: an updated review

Open access
Leung, Alexander KC, Hon, Kam Lun·2019·Drugs in Context
DOI 10.7573/dic.212591PMC PMC6586172
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Abstract

BACKGROUND: Gastroesophageal reflux is a common disorder in pediatrics. Clinicians should be familiar with the proper evaluation and management of this condition. OBJECTIVE: To provide an update on the current understanding, evaluation, and management of gastroesophageal reflux in children. METHODS: A PubMed search was performed with Clinical Queries using the key term 'gastroesophageal reflux'. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to the English literature and the pediatric age group. RESULTS: Regurgitation is the most frequent symptom of gastroesophageal reflux and is present in nearly all cases. Gastroesophageal reflux occurs normally in infants, is often physiological, peaks at 4 months of age, and tends to resolve with time. Gastroesophageal reflux disease occurs when gastric contents reflux into the esophagus or oropharynx and produce troublesome symptom(s) and/or complication(s). A thorough clinical history and a thorough physical examination are usually adequate for diagnosis. When the diagnosis is ambiguous, diagnostic studies may be warranted. A combined esophageal pH monitoring and multichannel intraluminal esophageal electrical impedance device is the gold standard for the diagnosis of gastroesophageal reflux disease if the diagnosis is in doubt. In the majority of cases, no treatment is necessary for gastroesophageal reflux apart from reassurance of the benign nature of the condition. Treatment options for gastroesophageal reflux disease are discussed. CONCLUSION: -receptor antagonists because of their superior efficacy. Antireflux surgery is indicated for patients with significant gastroesophageal reflux disease who are resistant to medical therapy.

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  • Gastroesophageal reflux disease may present with episodes of abrupt arousal from sleep, irritability, excessive crying, opisthotonus, and torticollis.

    “Gastroesophageal reflux disease may present with episodes of abrupt arousal from sleep, irritability, excessive crying, opisthotonus, and torticollis [71].”

    From Sleep Terrors: An Updated Review (2020) · cites this paper as [71]

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Metadata

Authors
Leung, A. K., & Hon, K. L.
Affiliations
  • University of Calgary (CA)
  • Chinese University of Hong Kong (HK)
Corresponding author
Leung, Alexander KC
ORCID
Venue
Drugs in Context
Publisher
BioExcel
Published
2019-06-17
Volume
8
Pages
1-12
ISSN
1740-4398 (ISSN-L)
DOI
10.7573/dic.212591
PMC
PMC6586172
OpenAlex
W2952682896
Cited by
109
References
107
Citations by year
2026: 11 · 2025: 8 · 2024: 15 · 2023: 25 · 2022: 20 · 2021: 12 · 2020: 9 · 2019: 7
FWCI
10.93
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Drugs in Context (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Esophageal and GI Pathology
Keywords
gastroesophageal reflux disease, pediatric gastroesophageal reflux, regurgitation, physiological reflux, esophageal pH monitoring, multichannel intraluminal impedance, diagnosis, antireflux surgery, H2 receptor antagonists, medical therapy, infants

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