The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Caracterización y seguimiento a 6 meses de una cohorte de recién nacidos con sífilis congénita
Open accessAbstract
INTRODUCTION: Congenital syphilis is a preventable disease. However, the incidence in Colombia has increased and reached the figure of 3.28 cases per 1,000 live births in 2011. OBJECTIVE: To characterize newborns with congenital syphilis and describe follow-up over 6 months following their diagnosis and treatment. MATERIALS AND METHODS: Between August, 2011, and February, 2012, in Hospital La Victoria, sede Instituto Materno Infantil, newborns with congenital syphilis were identified and treated. Clinical and laboratory follow-up was carried out for six months until it was determined that the disease was cured. The analyzed variables included patients' clinical and laboratory characteristics. RESULTS: In this period, we identified 29 cases that met the criteria of congenital syphilis, with a frequency in the institution of one case per 69 births. There was one stillbirth and one neonatal death, four were premature, and five had growth restriction. Of the 28 live births, 15 were asymptomatic. There were two cases with neurosyphilis, representing 15% of symptomatic newborns. Follow-up was done on 18 out of 27 children (66.6%), including most symptomatic cases and the two cases of neurosyphilis. All cases showed the expected decrease in VDRL titers without clinical sequelae, meeting the criteria of being cured. CONCLUSIONS: A high incidence of the disease, failure to prevent it, varied expression in its presentation, and the effectiveness of treatment in the neonatal period were evidenced in this study.
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“Between 2.5% and 27% of neonates with congenital syphilis may have central nervous system (CNS) involvement 41-43.”
From Efectividad del tratamiento de la sífilis gestacional en el último trimestre sobre la incidencia de sífilis congénita: revisión sistemática y metanálisis (2025) · cites this paper as [43]
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Cites
Infectious Diseases of the Fetus and Newborn Infant
Remington, J. S., & Klein, J. O. (1984) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198401000-00024 · Cited by 2,460
Efficacy of Treatment for Syphilis in Pregnancy
ALEXANDER, J. M., SHEFFIELD, J. S., SANCHEZ, P. J., MAYFIELD, J., & WENDEL, G. D. (1999) · Obstetrics & Gynecology · doi:10.1097/00006250-199901000-00002 · Cited by 213
Syphilis in Children: Congenital and Acquired
Woods, C. R. (2005) · Seminars in Pediatric Infectious Diseases · doi:10.1053/j.spid.2005.06.005 · Cited by 176
Fetal syphilis: clinical and laboratory characteristics
Hollier, L. (2001) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(01)01367-9 · Cited by 160
The prevention and management of congenital syphilis: an overview and recommendations.
Saloojee, H., Velaphi, S., Goga, Y., Afadapa, N., Steen, R., & Lincetto, O. (2004) · Europe PMC (PubMed Central) · Cited by 159
Sánchez, P. J., Wendel, G. D., Grimprel, E., Goldberg, M., Hall, M., Mireles, O., Radolf, J. D., & Norgard, M. V. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.1.148 · Cited by 147
Central Nervous System Infection in Congenital Syphilis
Michelow, I. C., Wendel, G. D., Norgard, M. V., Zeray, F., Leos, N. K., Alsaadi, R., & Sánchez, P. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012684 · Cited by 146
Jafari, Y., Peeling, R. W. W., Shivkumar, S., Claessens, C., Joseph, L., & Pai, N. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054695 · Cited by 146
A review of diagnostic tests for congenital syphilis in newborns
Herremans, T., Kortbeek, L. M., & Notermans, D. W. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-0900-8 · Cited by 135
Clinical Features and Follow-up of Congenital Syphilis
Lago, E. G., Vaccari, A., & Fiori, R. M. (2013) · Sexually Transmitted Diseases · doi:10.1097/olq.0b013e31827bd688 · Cited by 123
Cited by
Gestational and congenital syphilis: maternal, neonatal characteristics and outcome of cases
Soares, L. G., Zarpelon, B. L., Soares, L. G., Baratieri, T., Lentsck, M. H., & Mazza, V. D. A. (2017) · Revista Brasileira de Saúde Materno Infantil · doi:10.1590/1806-93042017000400010 · Cited by 78
PERFIL DOS CASOS NOTIFICADOS DE SÍFILIS CONGÊNITA
Moreira, K. F. A., de Oliveira, D. M., de Alencar, L. N., Cavalcante, D. F. B., Pinheiro, A. D. S., & Órfão, N. H. (2017) · Cogitare Enfermagem · doi:10.5380/ce.v22i2.48949 · Cited by 40
Luo, H., Qiu, L., Wu, Y., & Zhang, X. (2019) · Scientific Reports · doi:10.1038/s41598-019-40134-3 · Cited by 11
Sífilis congénita resultado de una Neurosífilis materna no diagnosticada. Reporte de caso
Yolanda Cifuentes, C., Ángel‐Müller, E., & Moreno, R. C. D. (2020) · Revista Médicas UIS · doi:10.18273/revmed.v33n1-2020009 · Cited by 6
Olarte, N. M., Valderrama, A., Corredor, J. E. C., Raba, A. M., Jiménez, J. M., & Mojica, J. A. (2024) · Revista Colombiana de Obstetricia y Ginecología · doi:10.18597/rcog.4198 · Cited by 3
Metadata
- Authors
- Vallejo, C., & Cifuentes, Y.
- Affiliations
- Universidad Nacional de Colombia (CO)
- Venue
- Biomédica
- Published
- 2015-08-24
- Volume
- 36
- Issue
- 1
- Pages
- 101-8
- ISSN
- 0120-4157 (ISSN-L)
- OpenAlex
- W1498246701
- Cited by
- 11
- References
- 24
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2020: 2 · 2019: 1 · 2017: 2
- FWCI
- 0.49
- Type
- journal article
- Language
- es
- Open access
- diamond
- doi.org
- Locations
- Biomédica (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Keywords
- congenital syphilis, neonates, neurosyphilis, VDRL titers, syphilis treatment, follow-up, stillbirth, neonatal death, growth restriction, Colombia
- MeSH terms
- Colombia, Female, Fetal Growth Retardation, Follow-Up Studies, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Neurosyphilis, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Prospective Studies, Syphilis Serodiagnosis, Syphilis, Congenital, Incidence, Stillbirth
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- The paper
- Vallejo, C., & Cifuentes, Y. (2015). Caracterización y seguimiento a 6 meses de una cohorte de recién nacidos con sífilis congénita. Biomédica. https://doi.org/10.7705/biomedica.v36i1.2661
