Cited by 11Genetic Associations and EpidemiologyFamily Dynamics and RelationshipsAnimal Behavior and Reproduction
The Sociogenomics of Polygenic Scores of Reproductive Behavior and Their Relationship to Other Fertility Traits
Open accessMills, Melinda C., Barban, Nicola, Tropf, Felix C.·2018·RSF: The Russell Sage Foundation Journal of the Social Sciences
Abstract
Human reproductive behavior until relatively recently has been explained exclusively via individual and social characteristics. This article applies results from a recent Genome-Wide Association Study that combined sixty-two data sources to isolate twelve genetic loci associated with reproductive behavior. We create polygenic scores that allow us to include a summary variable of genetic factors into our statistical models. We use four datasets: the U.S. Health and Retirement Study, Dutch LifeLines, TwinsUK and the Swedish Twin register. First, we provide a brief overview of the dominant explanations of reproductive behavior. Second, we test the predictive power of polygenic scores. Third, we interrogate the robustness of our models using a series of sensitivity analyses to take into account possible confounders due to population stratification and selection.
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Since AM is strong for all of these phenotypes, these results suggest that larger LDSC SNP heritability estimates from population effects are primarily due to AM, with the influence of population stratification diminished to the degree that LDSC successfully adjusts for it.
“Since AM is strong for all of these phenotypes31 (AM is likely for age at first birth in women indirectly due to the correlation of age at first birth with EA29,37), these results suggest that larger LDSC SNP heritability estimates from population effects are primarily due to AM6, with the influence of population stratification diminished to the degree that LDSC successfully adjusts for it.”
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References 54 · Cited by 11
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- Authors
- Mills, M. C., Barban, N., & Tropf, F. C.
- Affiliations
- University of Oxford (GB)
- Venue
- RSF: The Russell Sage Foundation Journal of the Social Sciences
- Publisher
- Russell Sage Foundation
- Published
- 2018-01-01
- Volume
- 4
- Issue
- 4
- Pages
- 122-136
- ISSN
- 2377-8253 (ISSN-L)
- 2377-8261
- OpenAlex
- W2795856187
- Cited by
- 11
- References
- 54
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- RSF The Russell Sage Foundation Journal of the Social Sciences (publishedVersion, cc-by-nc-nd)
- Open Access at Essex (University of Essex) (acceptedVersion)
- Project Muse (Johns Hopkins University) (submittedVersion, cc-by-nc-nd)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Wellcome Trust
- International Seafood Sustainability Foundation
- European Commission (615603, 320116)
- Economic and Social Research Council (ES/N011856/1)
- ESRC National Centre for Research Methods, University of Southampton
- FP7 Ideas: European Research Council (615603)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Demography › Family Dynamics and Relationships
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- reproductive behavior, fertility, polygenic risk score, genetic loci, sociogenomics, reproductive traits, population stratification, selection bias, twin studies, Health and Retirement Study, lifelines, TwinsUK
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