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Compulsive Sexual Behavior and Alcohol Use Disorder Treated With Naltrexone: A Case Report and Literature Review
Open accessAbstract
Compulsive sexual behavior (CSB) or sexual addiction is a term that generally indicates excessive and uncontrolled sexual behavior. This may lead to subjective distress, social and occupational impairment, or legal and financial consequences. Often, this condition is underreported and untreated. Until now there are no FDA-approved medications for sexual addiction or compulsive sexual behaviors. However, the therapeutic benefits of selective serotonin reuptake inhibitors (SSRIs) and naltrexone are known. This is a case of a 53-year-old male with a history of extensive alcohol use, alcohol withdrawal seizure, and delirium tremens. The patient was treated with naltrexone 50 mg/day for alcohol use disorder. The patient reported that his "sexual compulsion" also reduced after the medication and there was an improvement in both alcohol addiction and self-reported compulsive sexual behavior. This case report also includes a literature review of pharmacotherapy, especially naltrexone, for the treatment of sexual addiction/compulsive sexual behavior. The literature review has shown that patients' symptoms were improved in different doses without side effects, and based on this and our experience, it can be said that naltrexone is effective in the reduction and remission of the symptoms of CSB or sexual addiction.
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“The success of the opioid antagonist naltrexone in treating sex addiction, also used to treat drug addiction, (Grant and Kim, 2001;Kraus et al., 2015;Sultana and Din, 2022) is compatible with an addiction model for sexual behavior.”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Sultana and Din, 2022
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Naltrexone in compulsive sexual behavior disorder: a feasibility study of twenty men
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Sorted by citations
A motivation model of sex addiction – Relevance to the controversy over the concept
Toates, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104872 · Cited by 25
Metadata
- Authors
- Sultana, T., & Sahib Din, J.
- Affiliations
- Manhattan Psychiatric Center (US)
- Corresponding author
- Sultana, Tania
- ORCID
- Sultana, Tania
- Venue
- Cureus
- Published
- 2022-06-09
- Volume
- 14
- Issue
- 6
- Pages
- e25804-e25804
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC9273192
- OpenAlex
- W4281778893
- Cited by
- 8
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 1 · 2022: 2
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- compulsive sexual behavior, sexual addiction, naltrexone, alcoholism, pharmacotherapy, alcohol withdrawal, delirium tremens, selective serotonin reuptake inhibitors, symptom remission
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