The Clinicopathological Profile of Eosinophilic Myocarditis
Open accessAbstract
Eosinophilic myocarditis (EM) is a rare form of myocarditis. As there is extreme diversity in its manifestations, the true incidence is difficult to assess and no proper epidemiological criteria are present. It generally presents with a wide array of clinical manifestations. Clinical presentation tends to differ in cases and not all the patients show the same signs and symptoms. The etiology of EM often remains obscure but potential causes have been identified which may include hypersensitivity to drugs, exposure to certain viruses and parasites, and hyper-eosinophilic syndromes. Endomyocardial biopsy is considered to be a gold standard for the diagnosis of EM. Echocardiography, cardiac magnetic resonance, and bio markers particularly serum eosinophilic cationic protein concentrations are also known to aid in diagnosis. EM may lead to progressive, irreversible, and fatal myocardial damage if prompt diagnosis is not made and therapy is not initiated. The current treatment regimens include corticosteroids, cytotoxic agents, and immunosuppressive therapy. However, a proper treatment criterion is yet to be established.
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Various conditions including infections, drugs, hypersensitivity, and autoimmune factors may be associated with the onset and progress of eosinophilic myocarditis.
“various conditions including infections, drugs, hypersensitivity, and autoimmune factors may be associated with the onset and progress of this disease.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [197]
Eosinophilic myocarditis leads to advanced heart disorders such as heart failure, fibrosis, and thrombosis.
“leading to advanced heart disorders such as heart failure, fibrosis, and thrombosis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [197]
Eosinophilic myocarditis is characterized by predominant infiltration of eosinophils in the myocardium.
“Eosinophilic myocarditis is characterized by a predominant infiltration of eosinophils in the myocardium”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [197]
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- [19]Myocarditis/inflammatory cardiomyopathy Cardiac Pathology Baandrup U 133 146 London Springer 2013
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
- Authors
- Sheikh, H., Siddiqui, M., Uddin, S. M. M., Haq, A., & Yaqoob, U.
- Affiliations
- Civil Hospital Karachi (PK)
- Corresponding author
- Uddin, Syed Mohammad Mazhar
- Venue
- Cureus
- Published
- 2018-12-03
- Volume
- 10
- Issue
- 12
- Pages
- e3677-e3677
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC6367107
- OpenAlex
- W2903277027
- Cited by
- 36
- References
- 46
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Eosinophilic Disorders and Syndromes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Rheumatology › IgG4-Related and Inflammatory Diseases
- Keywords
- eosinophilic myocarditis, clinicopathological profile, endomyocardial biopsy, eosinophil cationic protein, hypereosinophilic syndrome, drug hypersensitivity, echocardiography, cardiac magnetic resonance, corticosteroids, cytotoxic drugs, immunosuppressive therapy, myocardial injury
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