Severe Esophageal Stricture Caused by Esophageal Candidiasis in a Non-HIV Patient
Open accessAbstract
Esophageal candidiasis (EC) is a common opportunistic infection in immunocompromised individuals, often encountered in situations such as untreated HIV/AIDS or following organ transplantation with immunosuppressant usage. While the main manifestation of esophageal candidiasis is mucosal inflammation, its progression and severe cases may lead to esophageal complications like dysphagia, odynophagia, and weight loss. One of the rare complications is esophageal stricture (ES). Few cases have been reported in the literature to date. Esophageal candidiasis can lead to the formation of ES through chronic inflammation, tissue damage, fibrosis, scarring, and ultimately narrowing of the esophageal lumen. Patients with ES often present with dysphagia, odynophagia, and other symptoms related to impaired swallowing. Esophageal strictures related to EC could seriously affect the patient's quality of life. Malnutrition and weight loss can be easily encountered in those cases. So, prompt diagnosis and appropriate antifungal therapy are important. Management should include addressing the stricture through endoscopic dilation interventions. Timely recognition of this complication is crucial for improving patient outcomes and quality of life. We present the case of a 46-year-old male with EC complicated by severe ES, dysphagia, and weight loss of more than 30 lbs. The diagnosis was made based on the histopathological examination of the esophageal biopsies.
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e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7 · see citing works
“Oral fluconazole, at a dosage of 200–400 mg daily for 14–21 days, is the most commonly prescribed treat-ment [85].”
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- Authors
- Abdelfattah, A. H., & Mahgoub, A. M.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Mahgoub, Ali M
- ORCID
- Abdelfattah, Ahmed H
- Venue
- Cureus
- Published
- 2023-10-07
- Volume
- 15
- Issue
- 10
- Pages
- e46641-e46641
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC10627336
- OpenAlex
- W4387423090
- Cited by
- 2
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Esophageal and GI Pathology
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- esophageal candidiasis, esophageal stricture, non-HIV patients, dysphagia, weight loss, antifungal therapy, endoscopic dilation, esophageal fibrosis, opportunistic infections
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