Polyfluoroalkyl-Substances Detection in Junk Food Packing Materials Using Various Analytical Methods: A Review
Open accessAbstract
Per- and polyfluoroalkyl substances (PFAS) are unseen, dangerous organic compounds that can cause major health disorders. PFASs have been categorized as persistent, bioaccumulative, and toxic (PBT). This review provides knowledge about the PFASs present in junk food packaging materials, which can migrate into the food. Different types of samples were analyzed using the analytical methods. The most preferred method of extraction is ultrasonic-assisted extraction (UAE). It summarizes the analytical approaches of PFASs. The results of numerous studies show that perfluorooctanoic acid is the most often detected compound with high concentrations. The European Food Safety Authority (EFSA) announced that the tolerable weekly intake (TWI) of PFASs is 4.4 ng/kg. The US Environmental Protection Agency (EPA) has announced the limit for perfluorobutane sulfonic acid due to its toxicity level. These compounds have potential effects on both people's health and the biosphere. PFAS usage has to stop in the industries for a better future.
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PFAS-based tubing and catheters are widely used for intravenous fluid delivery, blood transfusion, and vascular access procedures.
“Blood contact devices: PFAS-based tubing and catheters are widely used for intravenous fluid delivery, blood transfusion, and vascular access procedures.”
From Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights (2025) · cites this paper as [19]
The Introduction and background discusses broad industrial uses of PFAS, while the Review focuses on detecting PFAS in food packaging; neither addresses blood-contact devices. Searches for catheters, intravenous delivery, blood transfusion, vascular access, and medical tubing found no passage supporting the claimed uses. (LLM, conf=0.76)
Experimental — accuracy not yet measuredThe inert surfaces of PFAS-based blood contact devices reduce hemolysis and thrombogenicity.
“Their inert surfaces reduce hemolysis and thrombogenicity [19].”
From Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights (2025) · cites this paper as [19]
The Introduction and background discusses PFAS resistance and uses in food packaging, while the Review addresses PFAS detection and health risks; neither section addresses blood-contact devices. Searches for hemolysis, thrombogenicity, and blood-contacting devices found no passage supporting the claimed reduction. (LLM, conf=0.75)
Experimental — accuracy not yet measured
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Research works printed but not linked: 1
- [14]Development of non-targeted workflows for analysis SSRN Stroski KM Sapozhnikova Y Taylor RB Harron A 4784805 39 2024 https://ssrn.com/abstract 38797214
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- Authors
- S, J., Kannaiah, K. P., & Narayanasamy, D.
- Affiliations
- SRM Institute of Science and Technology (IN)
- Corresponding author
- Kannaiah, Kanaka Parvathi
- Venue
- Cureus
- Published
- 2024-09-27
- Volume
- 16
- Issue
- 9
- Pages
- e70301-e70301
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC11513209
- OpenAlex
- W4402929853
- Cited by
- 2
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1
- FWCI
- 0.06
- Type
- journal article
- Language
- en
- Open access
- diamond
- dx.doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- SRM Institute of Science and Technology
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- per- and polyfluoroalkyl substances, PFAS, food packaging materials, food packaging migration, junk food, perfluorooctanoic acid, PFBS, ultrasound-assisted extraction, analytical methods, tolerable weekly intake
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