Diagnosis and management of cerebral venous thrombosis
Open accessAbstract
Cerebral venous thrombosis (CVT) is rare and accounts for 0.5% of all strokes. Its clinical presentation is variable and diagnosis requires a high index of clinical suspicion in conjunction with neuroradiological diagnostic support. Treatment options are limited and are mostly based on consensus. Therefore, familiarity with international guidelines is important. Outcome is often good and most patients make a full recovery, although a small proportion suffers death or disability. Here, we describe the clinical features, risk factors, acute imaging features, management and complications of CVT.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mitochondrial dysfunction attenuates platelet survival and increases risk for thrombovascular events, increasing stroke risk.
“mitochondrial dysfunction attenuates platelet survival and increased risk for thrombovascular events (Kunz et al., 2017; Melchinger et al., 2019), increasing stroke risk (Behrouzi and Punter, 2018).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Behrouzi and Punter, 2018
The Introduction identifies cerebral venous thrombosis (CVT) as a cause of stroke and says a cerebral venous thrombus can lead to infarction. That supports a link between CVT and stroke, but the paper does not establish that thrombovascular events generally increase stroke risk. The platelet-survival and mitochondrial-dysfunction claims are attributed to other citations, not this one. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
No references could be resolved yet.
Research works printed but not linked: 30
- Bousser M-G , Ferro JM . Cerebral venous thrombosis: an update . Lancet Neurol 2007 ; 6 : 162 -70 .
- Coutinho JM , Zuurbier SM , Aramideh M , Stam J . The incidence of cerebral venous thrombosis: a cross-sectional study . Stroke 2012 ; 43 : 3375 -7 .
- Ferro JM , Canhao P . Cerebral venous sinus thrombosis: update on diagnosis and management . Curr Cardiol Rep 2014 ; 16 : 523 .
- Saposnik G , Barinagarrementeria F , Brown RD et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/ American Stroke Association . Stroke 2011 ; 42 : 1158 -92 .
- Bousser M-G , Russell RWR . Cerebral venous thrombosis . London : Saunders , 1997 .
- Stam J. Thrombosis of the cerebral veins and sinuses . N Engl J Med 2005 ; 352 : 1791 -8 .
- Einhaupl K , Stam J , Bousser M-G et al. EFNS guideline on the treat- ment of cerebral venous and sinus thrombosis in adult patients . Eur J Neurol 2010 ; 17 : 1229 -35 .
- Ferro JM , Bousser M-G , Canhão P et al. European Stroke Organization guideline for the diagnosis and treatment of cer- ebral venous thrombosis -endorsed by the European Academy of Neurology . Eur Stroke J 2017 ; 24 : 1203 -13 .
- Ferro JM , Canhão P , Stam J , Bousser M-G , Barinagarrementeria F . Prognosis of cerebral vein and dural sinus thrombosis . Stroke 2004 ; 35 : 664 -70 .
- Canhão P , Ferro JM , Lindgren AG et al. Causes and predictors of death in cerebral venous thrombosis . Stroke 2005 ; 36 : 1720 -5 .
- Alberti A , Venti M , Biagini S . Headache and cerebral vein and sinus thrombosis . Front Neurol Neurosci 2008 ; 23 : 89 -95 .
- Tentschert S , Wimmer R , Greisenegger S , Lang W , Lalouschek W . Headache at stroke onset in 2196 patients with ischemic stroke or transient ischemic attack . Stroke 2005 ; 36 : e1 -3 .
- Dávalos A , Cendra E , Genís D , López-Pousa S . The frequency, char- acteristics and prognosis of epileptic seizures at the onset of stroke . J Neurol Neurosurg Psychiatry 1988 ; 51 : 1464 .
- Saadatnia M , Fatehi F , Basiri K , Mousavi SA , Mehr GK . Cerebral venous sinus thrombosis risk factors . Int J Stroke 2009 ; 4 : 111 -23 .
- Coutinho JM , van den Berg R , Zuurbier SM et al. Small juxtacor- tical hemorrhages in cerebral venous thrombosis . Ann Neurol 2014 ; 75 : 908 -16 .
- Selim M , Caplan LR . Radiological diagnosis of cerebral venous thrombosis . Front Neurol Neurosci 2008 ; 23 : 96 -111 .
- Khandelwal N , Agarwal A , Kochhar R et al. Comparison of CT venography with MR venography in cerebral sinovenous throm- bosis . Am J Roentgenol 2006 ; 187 : 1637 -43 .
- Casey SO , Alberico RA , Patel M et al. Cerebral CT venography . Radiology 1996 ; 198 : 163 -70 .
- Einhäupl KM , Villringer A , Mehraein S et al. Heparin treatment in sinus venous thrombosis . Lancet 1991 ; 338 : 597 -600 .
- Bruijn SFTM de , Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis . Stroke 1999 ; 30 : 484 -8 .
- Misra UK , Kalita J , Chandra S , Kumar B , Bansal V . Low molecular weight heparin versus unfractionated heparin in cerebral venous sinus thrombosis: a randomized controlled trial . Eur J Neurol 2012 ; 19 : 1030 -6 .
- Canhão P , Falcão F , Ferro JM . Thrombolytics for cerebral sinus thrombosis: a systematic review . Cerebrovasc Dis 2003 ; 15 : 159 -66 .
- Stam J , Majoie CBLM , van Delden OM , van Lienden KP , Reekers JA . Endovascular thrombectomy and thrombolysis for severe cerebral sinus thrombosis . Stroke 2008 ; 39 : 1487 -90 .
- Canhão P , Cortesão A , Cabral M et al. Are steroids useful to treat cerebral venous thrombosis? Stroke 2008 ; 39 : 105 -10 .
- Aaron S , Alexander M , Moorthy RK et al. Decompressive craniec- tomy in cerebral venous thrombosis: a single centre experience . J Neurol Neurosurg Psychiatry 2013 ; 84 : 995 -1000 .
- Crassard I , Bousser M-G , Canhao P et al. Decompressive surgery in cerebrovenous thrombosis (CVT). A systematic review of individual patient data . Cerebrovasc Dis 2010 ; 29 : 286 .
- Kearon C , Akl EA , Ornelas J et al. Antithrombotic therapy for vte disease: chest guideline and expert panel report . Chest 2016 ; 149 : 315 -52 .
- Agarwal A , Lowry P , Isaacson G . Natural history of sigmoid sinus thrombosis . Ann Otol Rhinol Laryngol 2003 ; 112 : 191 -4 .
- van Es N , M Coppens , Schulman S , Middeldorp S , Büller HR . Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials . Blood 2014 ; 124 : 1968 -75 .
- Mendonça MD , Barbosa R , Cruz-e-Silva V , Calado S , Viana-Baptista M . Oral direct thrombin inhibitor as an alternative in the manage- ment of cerebral venous thrombosis: a series of 15 patients . Int J Stroke 2015 ; 10 : 1115 -8 .
Cited by
Sorted by citations
da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., Rathi, K. S., Smith, S. M., Stear, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.002 · Cited by 402 · see citing works
- Authors
- Behrouzi, R., & Punter, M.
- Affiliations
- Manchester University NHS Foundation Trust (GB)
- Salford Royal NHS Foundation Trust (GB)
- Venue
- Clinical Medicine
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 18
- Issue
- 1
- Pages
- 75-79
- ISSN
- 1470-2118 (ISSN-L)
- PMC
- PMC6330914
- OpenAlex
- W2786189262
- Cited by
- 100
- References
- 0
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 20 · 2022: 15 · 2021: 14 · 2020: 9 · 2019: 8
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Medicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Neurology › Cerebral Venous Sinus Thrombosis
- Health Sciences › Medicine › Neurology › Vascular Malformations Diagnosis and Treatment
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- cerebral venous thrombosis, clinical features, risk factors, neuroradiological diagnosis, anticoagulation, treatment options, complications, stroke, prognosis
- MeSH terms
- Humans, Patient Care Management, Sinus Thrombosis, Intracranial, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
