Effects of Oral Administering Kefir on Blood Glucose Levels in Diabetic Mice
Open accessAbstract
본 연구에서는 당뇨병 마우스에 kefir를 투여하여 혈당과 혈액의 지질성분의 변화를 측정하여 당뇨병 치료 보조식품으로의 가능성을 규명하고자 실시하였다. 당뇨병 마우스에 kefir를 매일 2회 $10\;m\ell/kg$ 씩 45일간 투여하여 혈당치를 비롯하여 사료섭취율, 몸무게 변화, 혈중 지질(중성지방, 고밀도 지질단백질, 저밀도지질단백질, 유리지방산)의 함량 변화와 간의 무게를 측정하였으며, 식염수와 10% 탈지우유를 투여한 대조군과 비교하였다. 당뇨병 마우스의 체중의 변화는 처리군 간에 유의차가 없었다. 혈당의 변화는 kefir 처리군이 음성대조군인 식염수와 탈지우유처리군에 비하여 45일 후에는 혈당치가 강하되어 유의차가 있었다(p<0.05). 혈청의 지질성분 정량 결과에서 혈청중의 중성지방 함량과 유리지방산 함량은 kefir 처리군이 음성대조군인 식염수와 탈지우유 처리군과 비교하여 45일째에 유의차가 있는 감소를 보였다(p<0.05). Kefir 처리군의 고밀도지질단백질 및 저밀도지질단백질 분석치는 대조군과 유의차가 없었다. 간의 무게는 처리군 간에 차이가 거의 없었다. 본 연구의 결과를 종합하면 당뇨병 마우스에 kefir를 45일간 급여하였을 때 대조군(식염수, 탈지우유)보다 혈당치와 중성지방이 강하된 것으로 보아 kefir 투여가 당뇨병 환자에게도 기능성 보조식품으로 활용할 수 있을 것으로 사료된다. This study was conducted to investigate the effect of oral administering kefir on blood glucose levels in diabetic mice. Kefir( $10\;m\ell/kg$ body weight) was orally administered to diabetic mice twice daily for 45 days. Diabetic mice fed saline or 10% skim milk were used as a control. No significant difference in feed intake and weight gain were observed among the treatments. Compared to the saline-fed or skim milk-fed group, blood glucose in the kefir-fed group decreased significantly at 45 days(p<0.05). At 45 days, serum triglyceride and non-esterified fatty acid concentrations in diabetic mice fed kefir decreased significantly compared to those of the saline and skim milk groups(p<0.05). Both high density lipoprotein and low density lipoprotein concentrations were not significantly different among the three treatment groups. In conclusion, the symptoms of diabetic mice improved when kefir was fed for >45 days.
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Milk <i>kefir</i> : nutritional, microbiological and health benefits
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- Authors
- Lee, J.-I., Song, K.-Y., Chon, J.-W., Hyeon, J.-Y., Kim, H.-S., & Seo, K.-H.
- Affiliations
- Konkuk University (KR)
- Corresponding author
- Song, Kwang-Young
- Venue
- The Korean Journal of Food And Nutrition
- Published
- 2011-03-30
- Volume
- 24
- Issue
- 1
- Pages
- 79-84
- ISSN
- 1225-4339 (ISSN-L)
- OpenAlex
- W1995667639
- Cited by
- 3
- References
- 24
- Citations by year
- 2018: 1 · 2017: 1 · 2013: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Korean Journal of Food And Nutrition (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- blood glucose, diabetes mellitus, functional foods, dietary fat, serum lipids, triglycerides, liver weight, diabetic mice, weight gain, low-fat milk, sodium chloride diet, high-fat diet, glycemic control, lipid metabolism, insulin resistance, hyperlipidemia, hyperglycemia
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