Hentze, Matthias W.

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

Anderson, S. A., Nizzi, C. P., Chang, Y.-I., Deck, K. M., Schmidt, P. J., Galy, B., Damnernsawad, A., Broman, A. T., Kendziorski, C., Hentze, M. W., et al. (2013) · Cell Metabolism

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 211

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

D’Alessio, F., Hentze, M. W., & Muckenthaler, M. U. (2012) · Journal of Hepatology

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 200

Nitric Oxide and Oxidative Stress (H2O2) Control Mammalian Iron Metabolism by Different Pathways

Pantopoulos, K., Weiss, G., & Hentze, M. W. (1996) · Molecular and Cellular Biology

Iron Metabolism and DisordersTrace Elements in Health

Cited by 195

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum

Galy, B., Ferring-Appel, D., Kaden, S., Gröne, H.-J., & Hentze, M. W. (2008) · Cell Metabolism

Iron Metabolism and DisordersTrace Elements in Health

Cited by 195

Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase

Hentze, M. W., & Argos, P. (1991) · Nucleic Acids Research

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 182

Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13

Weiss, G., Bogdan, C., & Hentze, M. W. (1997) · The Journal of Immunology

Iron Metabolism and DisordersImmune cells in cancer

Cited by 177

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia

Guida, C., Altamura, S., Klein, F. A., Galy, B., Boutros, M., Ulmer, A. J., Hentze, M. W., & Muckenthaler, M. U. (2015) · Blood

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 173

Iron induces anti-tumor activity in tumor-associated macrophages

Costa da Silva, M., Breckwoldt, M. O., Vinchi, F., Correia, M. P., Stojanovic, A., Thielmann, C. M., Meister, M., Muley, T., Warth, A., Platten, M., et al. (2017) · Frontiers in Immunology

Immune cells in cancerBacterial Cancer Therapy

Cited by 164

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

Casanovas, G., Mleczko-Sanecka, K., Altamura, S., Hentze, M. W., & Muckenthaler, M. U. (2009) · Journal of Molecular Medicine

Iron Metabolism and DisordersTGF-β signaling in diseases

Cited by 161

Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

Ludwiczek, S., Theurl, I., Muckenthaler, M. U., Jakab, M., Mair, S. M., Theurl, M., Kiss, J., Paulmichl, M., Hentze, M. W., Ritter, M., et al. (2007) · Nature Medicine

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 160

Iron regulatory proteins secure mitochondrial iron sufficiency and function

Galy, B., Ferring-Appel, D., Sauer, S. W., Kaden, S., Lyoumi, S., Puy, H., Kölker, S., Gröne, H.-J., & Hentze, M. W. (2010) · Cell Metabolism

Iron Metabolism and DisordersMitochondrial Function and Pathology

Cited by 147

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

Verga Falzacappa, M. V., Casanovas, G., Hentze, M. W., & Muckenthaler, M. U. (2008) · Journal of Molecular Medicine

Iron Metabolism and DisordersPlant Micronutrient Interactions and Effects

Cited by 146

Translational repression by a complex between the iron‐responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position‐dependent in vivo.

Goossen, B., Caughman, S. W., Harford, J. B., Klausner, R. D., & Hentze, M. W. (1990) · The EMBO Journal

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 144

Translational control via protein-regulated upstream open reading frames

Medenbach, J., Seiler, M., & Hentze, M. W. (2011) · Cell

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 140

Mechanism of escape from nonsense-mediated mRNA decay of human β-globin transcripts with nonsense mutations in the first exon

Neu-Yilik, G., Amthor, B., Gehring, N. H., Bahri, S., Paidassi, H., Hentze, M. W., & Kulozik, A. E. (2011) · RNA

RNA Research and SplicingHemoglobinopathies and Related Disorders

Cited by 140

Poly(A)-tail-promoted translation in yeast: Implications for translational control

PREISS, T., MUCKENTHALER, M., & HENTZE, M. W. (1998) · RNA

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 123

Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload

Altamura, S., Kessler, R., Gröne, H.-J., Gretz, N., Hentze, M. W., Galy, B., & Muckenthaler, M. U. (2014) · Cell Metabolism

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 119

A model for the structure and functions of iron-responsive elements

Hentze, M. W., Caughman, S. W., Casey, J. L., Kodier, D. M., Rouault, T. A., Harford, J. B., & Klausner, R. D. (1988) · Gene

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 116

The REM phase of gene regulation

Hentze, M. W., & Preiss, T. (2010) · Trends in Biochemical Sciences

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 115

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

Siegert, I., Schödel, J., Nairz, M., Schatz, V., Dettmer, K., Dick, C., Kalucka, J., Franke, K., Ehrenschwender, M., Schley, G., et al. (2015) · Cell Reports

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 110

Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection

Nairz, M., Ferring-Appel, D., Casarrubea, D., Sonnweber, T., Viatte, L., Schroll, A., Haschka, D., Fang, F. C., Hentze, M. W., Weiss, G., et al. (2015) · Cell Host & Microbe

Iron Metabolism and DisordersBacterial Genetics and Biotechnology

Cited by 103

SIREs: searching for iron-responsive elements

Campillos, M., Cases, I., Hentze, M. W., & Sanchez, M. (2010) · Nucleic Acids Research

RNA and protein synthesis mechanismsIron Metabolism and Disorders

Cited by 102

Iron regulatory proteins control a mucosal block to intestinal iron absorption

Galy, B., Ferring-Appel, D., Becker, C., Gretz, N., Gröne, H.-J., Schümann, K., & Hentze, M. W. (2013) · Cell Reports

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 98

The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis: evidence for function as the binding site for a translational repressor.

Caughman, S. W., Hentze, M. W., Rouault, T. A., Harford, J. B., & Klausner, R. D. (1988) · Journal of Biological Chemistry

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 85