Guy, Jacky

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Guy, J., Hendrich, B., Holmes, M., Martin, J. E., & Bird, A. (2001) · Nature Genetics

Genetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation

Cited by 1,558

Reversal of Neurological Defects in a Mouse Model of Rett Syndrome

Guy, J., Gan, J., Selfridge, J., Cobb, S., & Bird, A. (2007) · Science

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 1,230

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D., et al. (2010) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 625

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

Lyst, M. J., Ekiert, R., Ebert, D. H., Merusi, C., Nowak, J., Selfridge, J., Guy, J., Kastan, N. R., Robinson, N. D., de Lima Alves, F., et al. (2013) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation

Cited by 410

Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome

Kriaucionis, S., Paterson, A., Curtis, J., Guy, J., MacLeod, N., & Bird, A. (2006) · Molecular and Cellular Biology

Genetics and Neurodevelopmental DisordersMitochondrial Function and Pathology

Cited by 219

Preclinical research in Rett syndrome: setting the foundation for translational success

Katz, D. M., Berger-Sweeney, J. E., Eubanks, J. H., Justice, M. J., Neul, J. L., Pozzo-Miller, L., Blue, M. E., Christian, D., Crawley, J. N., Giustetto, M., et al. (2012) · Disease Models & Mechanisms

Genetics and Neurodevelopmental DisordersAnimal testing and alternatives

Cited by 206

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome

Robinson, L., Guy, J., McKay, L., Brockett, E., Spike, R. C., Selfridge, J., De Sousa, D., Merusi, C., Riedel, G., Bird, A., et al. (2012) · Brain

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 157

Radically truncated MeCP2 rescues Rett syndrome-like neurological defects

Tillotson, R., Selfridge, J., Koerner, M. V., Gadalla, K. K. E., Guy, J., De Sousa, D., Hector, R. D., Cobb, S. R., & Bird, A. (2017) · Nature

Genetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation

Cited by 155

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome

De Felice, C., Della Ragione, F., Signorini, C., Leoncini, S., Pecorelli, A., Ciccoli, L., Scalabrì, F., Marracino, F., Madonna, M., Belmonte, G., et al. (2014) · Neurobiology of Disease

Genetics and Neurodevelopmental DisordersRedox biology and oxidative stress

Cited by 126

Reversibility of functional deficits in experimental models of Rett syndrome

Cobb, S., Guy, J., & Bird, A. (2010) · Biochemical Society Transactions

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 67

Dysfunction of a SET3-like complex underlies a family of related neurological disorders

Paton, K. M., Alexander-Howden, B., Hare, J. I., Guy, J., Chhatbar, K., Yudina, M., Morris, S. T., Walls, R., Mathieson, T., Spanos, C., et al. (2026) · Nature Communications

Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases

Cited by 0

Tetramerisation governs SALL transcription factor function in development and disease

Giuliani, S., Chhatbar, K., Wear, M., Guy, J., Mathieson, T., Burdett, H., George, L., Alston, G., Spanos, C., McHugh, T., et al. (2025) · bioRxiv

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 0