Jacobson, Matthew P.

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

Shimazu, T., Hirschey, M. D., Hua, L., Dittenhafer-Reed, K. E., Schwer, B., Lombard, D. B., Li, Y., Bunkenborg, J., Alt, F. W., Denu, J. M., et al. (2010) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

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Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Metcalf, B., Chuang, C., Dufu, K., Patel, M. P., Silva-Garcia, A., Johnson, C., Lu, Q., Partridge, J. R., Patskovska, L., Patskovsky, Y., et al. (2017) · ACS Medicinal Chemistry Letters

Hemoglobinopathies and Related DisordersHemoglobin structure and function

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Evolutionarily conserved roles for blood-brain barrier xenobiotic transporters in endogenous steroid partitioning and behavior

Hindle, S. J., Munji, R. N., Dolghih, E., Gaskins, G., Orng, S., Ishimoto, H., Soung, A., DeSalvo, M., Kitamoto, T., Keiser, M. J., et al. (2017) · Cell Reports

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

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Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro

Butler, V. J., Cortopassi, W. A., Gururaj, S., Wang, A. L., Pierce, O. M., Jacobson, M. P., & Kao, A. W. (2019) · Biochemistry

Protease and Inhibitor MechanismsAlzheimer's disease research and treatments

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BCR::ABL1 kinase N-lobe mutants confer moderate to high degrees of resistance to asciminib

Leyte-Vidal, A., Garrido Ruiz, D., DeFilippis, R., Leske, I. B., Rea, D., Phan, S., Miller, K. B., Hu, F., Mase, A., Shan, Y., et al. (2024) · Blood

Chronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia Research

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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Butler, V. J., Gao, F., Corrales, C. I., Cortopassi, W. A., Caballero, B., Vohra, M., Ashrafi, K., Cuervo, A. M., Jacobson, M. P., Coppola, G., et al. (2019) · PLOS Genetics

Genetics, Aging, and Longevity in Model OrganismsAmyotrophic Lateral Sclerosis Research

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Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Sampognaro, P. J., Arya, S., Knudsen, G. M., Gunderson, E. L., Sandoval-Perez, A., Hodul, M., Bowles, K., Craik, C. S., Jacobson, M. P., & Kao, A. W. (2023) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

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