Tate, Edward W.

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature

Ferroptosis and cancer prognosisIron Metabolism and Disorders

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Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

Maneiro, M., Forte, N., Shchepinova, M. M., Kounde, C. S., Chudasama, V., Baker, J. R., & Tate, E. W. (2020) · ACS Chemical Biology

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 350

Structural basis for membrane attack complex inhibition by CD59

Couves, E. C., Gardner, S., Voisin, T. B., Bickel, J. K., Stansfeld, P. J., Tate, E. W., & Bubeck, D. (2022) · Nature Communications

Complement system in diseasesLipid Membrane Structure and Behavior

Cited by 86

Structural basis for membrane attack complex inhibition by CD59

Couves, E. C., Gardner, S., Voisin, T. B., Bickel, J. K., Stansfeld, P. J., Tate, E. W., & Bubeck, D. (2023) · Nature Communications

Complement system in diseasesLipid Membrane Structure and Behavior

Cited by 85

A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target

Kennedy, C. R., Goya Grocin, A., Kovačič, T., Singh, R., Ward, J. A., Shenoy, A. R., & Tate, E. W. (2021) · ACS Chemical Biology

Inflammasome and immune disordersEnzyme function and inhibition

Cited by 81

High‐Throughput Kinetic Analysis for Target‐Directed Covalent Ligand Discovery

Craven, G. B., Affron, D. P., Allen, C. E., Matthies, S., Greener, J. G., Morgan, R. M. L., Tate, E. W., Armstrong, A., & Mann, D. J. (2018) · Angewandte Chemie International Edition

Click Chemistry and ApplicationsHeterocyclic Compound Synthesis and Bioactivity

Cited by 73

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

Ocasio, C. A., Baggelaar, M. P., Sipthorp, J., Losada de la Lastra, A., Tavares, M., Volarić, J., Soudy, C., Storck, E. M., Houghton, J. W., Palma-Duran, S. A., et al. (2024) · Nature Biotechnology

Click Chemistry and ApplicationsLipid metabolism and biosynthesis

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