Motooka, Daisuke

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

Maeda, Y., Kurakawa, T., Umemoto, E., Motooka, D., Ito, Y., Gotoh, K., Hirota, K., Matsushita, M., Furuta, Y., Narazaki, M., et al. (2016) · Arthritis & Rheumatology

Gut microbiota and healthRheumatoid Arthritis Research and Therapies

Cited by 686

Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota

Arimatsu, K., Yamada, H., Miyazawa, H., Minagawa, T., Nakajima, M., Ryder, M. I., Gotoh, K., Motooka, D., Nakamura, S., Iida, T., et al. (2014) · Scientific Reports

Oral microbiology and periodontitis researchGut microbiota and health

Cited by 573

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Kidani, Y., Nogami, W., Yasumizu, Y., Kawashima, A., Tanaka, A., Sonoda, Y., Tona, Y., Nashiki, K., Matsumoto, R., Hagiwara, M., et al. (2022) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 212

Periportal macrophages protect against commensal-driven liver inflammation

Miyamoto, Y., Kikuta, J., Matsui, T., Hasegawa, T., Fujii, K., Okuzaki, D., Liu, Y.-C., Yoshioka, T., Seno, S., Motooka, D., et al. (2024) · Nature

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 135

Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection

Tanaka, A., Tumkosit, U., Nakamura, S., Motooka, D., Kishishita, N., Priengprom, T., Sa-ngasang, A., Kinoshita, T., Takeda, N., & Maeda, Y. (2017) · Journal of Virology

Mosquito-borne diseases and controlProteoglycans and glycosaminoglycans research

Cited by 108

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases

Yasumizu, Y., Takeuchi, D., Morimoto, R., Takeshima, Y., Okuno, T., Kinoshita, M., Morita, T., Kato, Y., Wang, M., Motooka, D., et al. (2024) · Cell Genomics

Single-cell and spatial transcriptomicsT-cell and B-cell Immunology

Cited by 60

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

Kayama, H., Kohyama, M., Okuzaki, D., Motooka, D., Barman, S., Okumura, R., Muneta, M., Hoshino, K., Sasaki, I., Ise, W., et al. (2018) · Proceedings of the National Academy of Sciences

Inflammatory Bowel DiseaseImmune Response and Inflammation

Cited by 55

Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer

Kitakaze, M., Uemura, M., Hara, T., Chijimatsu, R., Motooka, D., Hirai, T., Konno, M., Okuzaki, D., Sekido, Y., Hata, T., et al. (2023) · British Journal of Cancer

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 49

Prokaryotic and viral genomes recovered from 787 Japanese gut metagenomes revealed microbial features linked to diets, populations, and diseases

Tomofuji, Y., Kishikawa, T., Maeda, Y., Ogawa, K., Otake-Kasamoto, Y., Kawabata, S., Nii, T., Okuno, T., Oguro-Igashira, E., Kinoshita, M., et al. (2022) · Cell Genomics

Bacteriophages and microbial interactionsGut microbiota and health

Cited by 35

The cell wall polymer initiates plasma membrane partitioning in mycobacteria

Kado, T., Akbary, Z., Motooka, D., Sparks, I. L., Melzer, E. S., Nakamura, S., Rojas, E. R., Morita, Y. S., & Siegrist, M. S. (2022) · eLife

Lipid Membrane Structure and BehaviorBacterial Genetics and Biotechnology

Cited by 16

Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance

Wakita, M., Ito, K., Fujii, K., Sakamoto, D., Mikawa, T., Sugawara, S., Zhou, X., Park, J. H., Miyagawa, H., Motooka, D., et al. (2026) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 9

Identifying genetic variations in emm89 Streptococcus pyogenes associated with severe invasive infections

Ono, M., Yamaguchi, M., Motooka, D., Hirose, Y., Higashi, K., Sumitomo, T., Miyoshi-Akiyama, T., Okuno, R., Yamaguchi, T., Kawahara, R., et al. (2025) · eLife

Streptococcal Infections and TreatmentsAntimicrobial Resistance in Staphylococcus

Cited by 4

Identifying genetic variations in emm89 Streptococcus pyogenes associated with severe invasive infections

Ono, M., Yamaguchi, M., Motooka, D., Hirose, Y., Higashi, K., Sumitomo, T., Miyoshi-Akiyama, T., Okuno, R., Yamaguchi, T., Kawahara, R., et al. (2025) · eLife

Streptococcal Infections and TreatmentsAntimicrobial Resistance in Staphylococcus

Cited by 0