Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota
Open accessAbstract
Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases and non-alcoholic fatty liver disease. Although bacteremias from dental plaque and/or elevated circulating inflammatory cytokines emanating from the inflamed gingiva are suspected mechanisms linking periodontitis and these diseases, direct evidence is lacking. We hypothesize that disturbances of the gut microbiota by swallowed bacteria induce a metabolic endotoxemia leading metabolic disorders. To investigate this hypothesis, changes in the gut microbiota, insulin and glucose intolerance and levels of tissue inflammation were analysed in mice after oral administration of Porphyromonas gingivalis , a representative periodontopathogens. Pyrosequencing revealed that the population belonging to Bacteroidales was significantly elevated in P. gingivalis -administered mice which coincided with increases in insulin resistance and systemic inflammation. In P. gingivalis -administered mice blood endotoxin levels tended to be higher, whereas gene expression of tight junction proteins in the ileum was significantly decreased. These results provide a new paradigm for the interrelationship between periodontitis and systemic diseases.
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Oral administration of P. gingivalis coincides with the development of systemic inflammation and onset of insulin resistance in mice.
“Oral administration of P. gingivalis coincides with the development of systemic inflammation and onset of insulin resistance in mice (Arimatsu et al. 2014).”
From The oral microbiota is modified by systemic diseases. (2019) · cites this paper as Arimatsu et al. 2014
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“…consistent with oral-to-gut microbial translocation comes from 16S rRNA sequencing studies demonstrating enrichment of oral cavity-associated taxa in the fecal microbiome of patients with periodontitis; however, these associations do not establish active translocation or causality [51,52,56].”
- Authors
- Arimatsu, K., Yamada, H., Miyazawa, H., Minagawa, T., Nakajima, M., Ryder, M. I., Gotoh, K., Motooka, D., Nakamura, S., Iida, T., & Yamazaki, K.
- Affiliations
- Niigata University (JP)
- University of California, San Francisco (US)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Corresponding author
- Yamazaki, Kazuhisa
- ORCID
- Venue
- Scientific Reports
- Published
- 2014-05-06
- Volume
- 4
- Issue
- 1
- Pages
- 4828-4828
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4010932
- OpenAlex
- W2033021581
- Cited by
- 573
- References
- 63
- Citations by year
- 2026: 57 · 2025: 48 · 2024: 65 · 2023: 61 · 2022: 58 · 2021: 70 · 2020: 66 · 2019: 39 · 2018: 40 · 2017: 32 · 2016: 19 · 2015: 11 · 2014: 6
- FWCI
- 30.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Japan Society for the Promotion of Science (23390476, 25670882)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- periodontitis, Porphyromonas gingivalis, gut microbiota, oral pathobionts, endotoxemia, systemic inflammation, insulin resistance, impaired glucose tolerance, Bacteroidales, tight junction proteins, ileum, metabolic disorders
- MeSH terms
- Animals, Dental Plaque, Diabetes Mellitus, Type 2, Disease Models, Animal, Gingiva, Ileum, Inflammation, Insulin, Insulin Resistance, Male, Metabolic Diseases, Mice, Inbred C57BL, Periodontitis, Cytokines, Porphyromonas gingivalis, Glucose Intolerance, Endotoxemia, Mice, Tight Junction Proteins, Microbiota
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