Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer
Open accessAbstract
Background: Tissue-resident memory T (Trm) cells are associated with cytotoxicity not only in viral infection and autoimmune disease pathologies but also in many cancers. Tumour-infiltrating CD103+ Trm cells predominantly comprise CD8 T cells that express cytotoxic activation and immune checkpoint molecules called exhausted markers. This study aimed to investigate the role of Trm in colorectal cancer (CRC) and characterise the cancer-specific Trm. Methods: Immunochemical staining with anti-CD8 and anti-CD103 antibodies for resected CRC tissues was used to identify the tumour-infiltrating Trm cells. The Kaplan–Meier estimator was used to evaluate the prognostic significance. Cells immune to CRC were targeted for single-cell RNA-seq analysis to characterise cancer-specific Trm cells in CRC. Results: The number of CD103+/CD8+ tumour-infiltrating lymphocytes (TILs) was a favourable prognostic and predictive factor of the overall survival and recurrence-free survival in patients with CRC. Single-cell RNA-seq analysis of 17,257 CRC-infiltrating immune cells revealed a more increased zinc finger protein 683 (ZNF683) expression in cancer Trm cells than in noncancer Trm cells and in high-infiltrating Trm cells than low-infiltrating Trm in cancer, with an upregulated T-cell receptor (TCR)- and interferon-γ (IFN-γ) signalling-related gene expression in ZNF683+ Trm cells. Conclusions: The number of CD103+/CD8+ TILs is a prognostic predictive factor in CRC. In addition, we identified the ZNF683 expression as one of the candidate markers of cancer-specific Trm cells. IFN-γ and TCR signalling and ZNF683 expression are involved in Trm cell activation in tumours and are promising targets for cancer immunity regulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TRM cells can be identified by upregulation of specific transcription factors such as HOBIT, RUNX3, and BLIMP-1, which lead to transcriptional reprogramming to downregulate tissue egress genes and upregulate tissue retention markers.
“Additionally, T RM cells can be identified by the upregulation of specific transcription factors such as HOBIT (homolog of Blimp-1 in T cells), RUNX3 (runt-related transcription factor 3), and BLIMP-1 (B lymphocyte-induced maturation protein-1), which lead to transcriptional reprogramming to downregulate tissue egress genes and upregulate tissue retention markers. 295-298”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [298]
The Results section (‘The characteristics of ZNF683+ Trm’) identifies HOBIT/ZNF683 as a transcription factor and a reported core gene of Trm cells; the Discussion also identifies it as homologous to BLIMP-1. Our copy does not establish RUNX3 or BLIMP-1 upregulation as ways to identify Trm cells, or say that these factors downregulate tissue-egress genes and upregulate retention markers. No page numbers are available in the indexed passages. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589 · see citing works
Decoding the Patterns of Self and Nonself by the Innate Immune System
Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154 · see citing works
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · see citing works
CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.
Naito, Y., Saito, K., Shiiba, K., Ohuchi, A., Saigenji, K., Nagura, H., & Ohtani, H. (1998) · PubMed · Cited by 1,193 · see citing works
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059 · cited 1× · see citing works
“Trm cells remain in peripheral tissues for a long time [7].”
BackgroundHobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Mackay, L. K., Minnich, M., Kragten, N. A. M., Liao, Y., Nota, B., Seillet, C., Zaid, A., Man, K., Preston, S., Freestone, D., et al. (2016) · Science · doi:10.1126/science.aad2035 · Cited by 1,010 · see citing works
Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Savas, P., Virassamy, B., Ye, C., Salim, A., Mintoff, C. P., Caramia, F., Salgado, R., Byrne, D. J., Teo, Z. L., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0078-7 · Cited by 992 · see citing works
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
Duhen, T., Duhen, R., Montler, R., Moses, J., Moudgil, T., de Miranda, N. F., Goodall, C. P., Blair, T. C., Fox, B. A., McDermott, J. E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05072-0 · Cited by 938 · see citing works
Role of T-bet in Commitment of T H 1 Cells Before IL-12-Dependent Selection
Mullen, A. C., High, F. A., Hutchins, A. S., Lee, H. W., Villarino, A. V., Livingston, D. M., Kung, A. L., Cereb, N., Yao, T., Yang, S. Y., et al. (2001) · Science · doi:10.1126/science.1059835 · Cited by 825 · see citing works
Resident memory CD8 T cells trigger protective innate and adaptive immune responses
Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. (2014) · Science · doi:10.1126/science.1254536 · Cited by 731 · see citing works
CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin
Cheuk, S., Schlums, H., Gallais Sérézal, I., Martini, E., Chiang, S. C., Marquardt, N., Gibbs, A., Detlofsson, E., Introini, A., Forkel, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.009 · Cited by 678 · see citing works
Badoual, C., Hans, S., Merillon, N., Ryswick, C. V., Ravel, P., Benhamouda, N., Levionnois, É., Nizard, M., Si‐Mohamed, A., Besnier, N., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2606 · Cited by 637 · see citing works
Djenidi, F., Adam, J., Goubar, A., Durgeau, A., Meurice, G., de Montpréville, V., Validire, P., Besse, B., & Mami-Chouaib, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402711 · Cited by 622 · see citing works
Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers
Badoual, C., Hans, S., Rodriguez, J., Peyrard, S., Klein, C., Agueznay, N. E. H., Mosseri, V., Laccourreye, O., Bruneval, P., Fridman, W. H., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1886 · Cited by 595 · see citing works
Machado-Santos, J., Saji, E., Tröscher, A. R., Paunovic, M., Liblau, R., Gabriely, G., Bien, C. G., Bauer, J., & Lassmann, H. (2018) · Brain · doi:10.1093/brain/awy151 · Cited by 548 · see citing works
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
Caushi, J. X., Zhang, J., Ji, Z., Vaghasia, A. M., Zhang, B., Hsiue, E. H.-C., Mog, B. J., Hou, W., Justesen, S. F. L., Blosser, R. L., et al. (2021) · Nature · doi:10.1038/s41586-021-03752-4 · Cited by 539 · see citing works
Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert
Ariotti, S., Hogenbirk, M. A., Dijkgraaf, F. E., Visser, L. L., Hoekstra, M. E., Song, J., Jacobs, H., Haanen, J. B. A. G., & Schumacher, T. N. (2014) · Science · doi:10.1126/science.1254803 · Cited by 534 · see citing works
Ganesan, A.-P., Clarke, J., Wood, O., Garrido-Martin, E. M., Chee, S. J., Mellows, T., Samaniego-Castruita, D., Singh, D., Seumois, G., Alzetani, A., et al. (2017) · Nature Immunology · doi:10.1038/ni.3775 · Cited by 528 · see citing works
Webb, J. R., Milne, K., Watson, P. H., deLeeuw, R. J., & Nelson, B. H. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1877 · Cited by 435 · see citing works
Edwards, J. J., Wilmott, J. S., Madore, J., Gide, T. N., Quek, C. Y. J., Tasker, A. T., Ferguson, A. L., Chen, J., Hewavisenti, R., Hersey, P., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2257 · Cited by 431 · see citing works
Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
Schön, M. P., Arya, A., Murphy, E. A., Adams, C. M., Strauch, U., Agace, W. W., Marsal, J., Donohue, J. P., Her, H., Beier, D. R., et al. (1999) · PubMed · Cited by 424 · see citing works
Mucosal T Lymphocyte Numbers Are Selectively Reduced in Integrin αE (CD103)-Deficient Mice
Schön, M. P., Arya, A., Murphy, E. A., Adams, C. M., Strauch, U., Agace, W. W., Marsal, J., Donohue, J. P., Her, H., Beier, D. R., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6641 · Cited by 399 · see citing works
Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin
Park, S. L., Buzzai, A. C., Rautela, J., Hor, J. L., Hochheiser, K., Effern, M., McBain, N., Wagner, T., Edwards, J. J., McConville, R., et al. (2018) · Nature · doi:10.1038/s41586-018-0812-9 · Cited by 378 · see citing works
Regional and mucosal memory T cells
Sheridan, B., & Lefrançois, L. (2011) · Nature Immunology · doi:10.1038/ni.2029 · Cited by 281 · see citing works
Schulz, E. G., Mariani, L., Radbruch, A., & Höfer, T. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.013 · Cited by 280 · see citing works
Tissue-resident memory T cells at the center of immunity to solid tumors
Amsen, D., van Gisbergen, K. P. J. M., Hombrink, P., & van Lier, R. A. W. (2018) · Nature Immunology · doi:10.1038/s41590-018-0114-2 · Cited by 278 · see citing works
Lugo‐Villarino, G., Maldonado-López, R., Possemato, R., Peñaranda, C., & Glimcher, L. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332767100 · Cited by 269 · see citing works
Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients
Deschoolmeester, V., Baay, M. F. D., Marck, E. V., Weyler, J., Vermeulen, P. B., Lardon, F., & Vermorken, J. B. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-19 · Cited by 235 · see citing works
Zundler, S., Becker, E., Spocinska, M., Slawik, M., Parga-Vidal, L., Stark, R., Wiendl, M., Atreya, R., Rath, T., Leppkes, M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0298-5 · Cited by 226 · see citing works
Kurd, N. S., He, Z., Louis, T. L., Milner, J. J., Omilusik, K. D., Jin, W., Tsai, M. S., Widjaja, C. E., Kanbar, J. N., Olvera, J. G., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz6894 · Cited by 209 · see citing works
Chiba, T., Ohtani, H., Mizoi, T., Naito, Y., Sato, E., Nagura, H., Ohuchi, A., Ohuchi, K., Shiiba, K., Kurokawa, Y., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602201 · Cited by 203 · see citing works
CD74 and intratumoral immune response in breast cancer
Wang, Z., Milne, K., Webb, J. R., & Watson, P. H. (2016) · Oncotarget · doi:10.18632/oncotarget.8610 · Cited by 201 · see citing works
Komdeur, F. L., Prins, T. M., van de Wall, S., Plat, A., Wisman, G. B. A., Hollema, H., Daemen, T., Church, D. N., de Bruyn, M., & Nijman, H. W. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1338230 · Cited by 168 · see citing works
Welters, M. J. P., Ma, W., Santegoets, S. J. A. M., Goedemans, R., Ehsan, I., Jordanova, E. S., van Ham, V. J., van Unen, V., Koning, F., van Egmond, S. I., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2140 · Cited by 167 · see citing works
Wang, B., Wu, S., Zeng, H., Liu, Z., Dong, W., He, W., Chen, X., Dong, X., Zheng, L., Lin, T., et al. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.02.2941 · Cited by 166 · see citing works
CD103 and Intratumoral Immune Response in Breast Cancer
Wang, Z., Milne, K., Derocher, H., Webb, J. R., Nelson, B. H., & Watson, P. H. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0732 · Cited by 156 · see citing works
Yang, R., Cheng, S., Luo, N., Gao, R., Yu, K., Kang, B., Wang, L., Zhang, Q., Fang, Q., Zhang, L., et al. (2019) · Genome biology · doi:10.1186/s13059-019-1921-y · Cited by 128 · see citing works
Blimp‐1 homolog Hobit identifies effector‐type lymphocytes in humans
Braga, F. A. V., Hertoghs, K. M. L., Kragten, N. A. M., Doody, G. M., Barnes, N. A., Remmerswaal, E. B. M., Hsiao, C., Moerland, P. D., Wouters, D., Derks, I. A. M., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545650 · Cited by 114 · see citing works
Local heroes or villains: tissue-resident memory T cells in human health and disease
Sasson, S. C., Gordon, C. L., Christo, S. N., Klenerman, P., & Mackay, L. K. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0359-1 · Cited by 111 · see citing works
Yin, Z., Chen, C.-H., Szabo, S. J., Glimcher, L. H., Ray, A., & Craft, J. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1566 · Cited by 103 · see citing works
Iwata, S., Mikami, Y., Sun, H., Brooks, S. R., Jankovic, D. L., Hirahara, K., Onodera, A., Shih, H., Kawabe, T., Jiang, K., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.005 · Cited by 89 · see citing works
van Gisbergen, K. P. J. M., Kragten, N. A. M., Hertoghs, K. M. L., Wensveen, F. M., Jonjić, S., Hamann, J., Nolte, M. A., & van Lier, R. A. W. (2012) · Nature Immunology · doi:10.1038/ni.2393 · Cited by 83 · see citing works
The evolving role of T-bet in resistance to infection
Pritchard, G. H., Kedl, R. M., & Hunter, C. A. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0145-4 · Cited by 82 · see citing works
Kuric, E., Seiron, P., Krogvold, L., Edwin, B., Buanes, T., Hanssen, K. F., Skog, O., Dahl-Jørgensen, K., & Korsgren, O. (2017) · The American Journal of Pathology · doi:10.1016/j.ajpath.2016.11.002 · Cited by 80 · see citing works
Hartana, C. A., Bergman, E. A., Broomé, A., Berglund, S., Johansson, M., Alamdari, F. I., Jakubczyk, T., Huge, Y., Aljabery, F. A.-S., Palmqvist, K., et al. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13183 · Cited by 60 · see citing works
Flagged first, then by citations
2 of the 48 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Davies, D., Kamdar, S., Woolf, R., Zlatareva, I., Iannitto, M. L., Morton, C., Haque, Y., Martin, H., Biswas, D., Ndagire, S., et al. (2024) · Nature Cancer · doi:10.1038/s43018-023-00690-0 · Cited by 64 · see citing works
Rausch, L., & Kallies, A. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082223-044122 · Cited by 60 · see citing works
Hugaboom, M. B., Wirth, L. V., Street, K., Ruthen, N. G., Jegede, O. A., Schindler, N. R., Shah, V., Zaemes, J. P., Ahmar, N. E., Matar, S., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0991 · Cited by 53 · see citing works
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
Maurer, K., Park, C. Y., Mani, S., Borji, M., Raths, F., Gouin, K. H., Penter, L., Jin, Y., Zhang, J. Y., Shin, C. S., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adr0782 · Cited by 40 · see citing works
Immune checkpoint blockade: timing is everything
Sinicrope, F. A., & Turk, M. J. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009722 · Cited by 34 · see citing works
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Lu, B. Y., Lucca, L. E., Lewis, W., Wang, J., Nogueira, C. V., Heer, S., Rayon-Estrada, V., Axisa, P., Reeves, S., Buitrago-Pocasangre, N., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-02023-4 · Cited by 18 · see citing works
Tissue‐resident memory T cells in diseases and therapeutic strategies
Xie, D., Lu, G., Mai, G., Guo, Q., & Xu, G. (2025) · MedComm · doi:10.1002/mco2.70053 · Cited by 18 · see citing works
Sun, L., Ren, C., Leng, H., Wang, X., Wang, D., Wang, T., Wang, Z., Zhang, G., & Yu, H. (2024) · Depression and Anxiety · doi:10.1155/2024/1089236 · Cited by 14 · see citing works
Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective
Murakami, M. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00333-6 · Cited by 13 · see citing works
Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma
Bi, K., Kashima, S., Camp, S. Y., Meli, K., Saad, E., Titchen, B. M., Labaki, C., Bakouny, Z., Pimenta, E. M., Park, J., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.10.013 · Cited by 11 · see citing works
Wang, C., Chen, J., Li, J., Xu, Z., Huang, L., Zhao, Q., Chen, L., Liang, X., Hu, H., Li, G., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172092 · Cited by 10 · see citing works
Abdeljaoued, S., Doussot, A., Kroemer, M., Laloy, E., Pallandre, J., Kaddissi, A. E., Spehner, L., Khelil, M. B., Bouard, A., Mougey, V., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2455176 · Cited by 10 · see citing works
Mellors, P. W., Lange, A. N., Remondo, B. C., Shestov, M., Planer, J. D., Peterson, A. R., Ying, Y., Zhou, S., Christie, J. D., Diamond, J. M., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.176596 · Cited by 10 · see citing works
Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy
Min, D., Fiedler, J., & Anandasabapathy, N. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102499 · Cited by 10 · see citing works
Yan, R., Jia, D., Qi, Y., Wang, Q., & Chen, S. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.03.021 · Cited by 9 · see citing works
Wang, C., Yu, X., Teer, J. K., Yao, J., Du, D., Liu, X., Thompson, Z., Wang, M. H., Welsh, E. A., Memon, D., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-00946-x · Cited by 9 · see citing works
Arnesen, H., Birkeland, S., Stendahl, H., Neuhaus, K., Masopust, D., Boysen, P., & Carlsen, H. (2025) · Discovery Immunology · doi:10.1093/discim/kyaf002 · Cited by 7 · see citing works
Zhang, T., Song, J., Li, Y., Shen, K., Xuan, J., Gao, Y., Lu, L., Pang, Z., Wang, L., Yang, Y., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70464 · Cited by 7 · see citing works
Chen, J., Mo, J., Wei, J., Qu, M., Dai, J., Kong, Y., Xu, H., Li, J., Yan, X., Cui, C., et al. (2025) · Advanced Science · doi:10.1002/advs.202514600 · Cited by 7 · see citing works
Tissue-Resident Memory T Cells in Cancer Metastasis Control
Montgomery, T., Master, A. P., Jin, Z., Shi, Q., Lai, Q., Desai, R., Zhang, W., Maharjan, C. K., & Kolb, R. H. (2025) · Cells · doi:10.3390/cells14161297 · Cited by 6 · see citing works
Tumor-infiltrating lymphocyte expansion protocols for adoptive cell therapy in cancer
Manzano, D. T., Subhi‐Issa, N., Pereiro-Rodríguez, A., Cade, I. G. L., González, M. M., Fernández‐Arquero, M., Segura, P. P., Ujaldón‐Miró, C., Sánchez‐Ramón, S., Ocaña, A., et al. (2025) · Cellular Oncology · doi:10.1007/s13402-025-01112-2 · Cited by 6 · see citing works
Jassowicz, L., Feng, F., Warta, R., Heinicke, F., Wöllner, A., Briesch, H., Sor, F., Soller, J., Lotsch, C., Wong, J. K. L., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.03.016 · Cited by 6 · see citing works
Cheng, K., Xu, J., Yang, J., & Zhang, Z. (2026) · BMC Cancer · doi:10.1186/s12885-026-15647-6 · Cited by 5 · see citing works
Chen, X., & Chen, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1531402 · Cited by 5 · see citing works
Sato, H., Meng, S., Hara, T., Tsuji, Y., Arao, Y., Sasaki, K., Kobayashi, S., di Luccio, E., Hirotsu, T., Satoh, T., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12061342 · Cited by 5 · see citing works
Self-citationLan, C., Qiu, M., & Lin, M. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251334447 · Cited by 4 · see citing works
Rewiring tumor immunity via zinc finger proteins: a new frontier in cancer immunotherapy
Zhou, Z., Le, W., Luo, J., Li, Z., & Zhong, S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07549-1 · Cited by 5 · see citing works
RNA biomarkers in cancer therapeutics: The promise of personalized oncology
Katifelis, H., & Gazouli, M. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.06.003 · Cited by 4 · see citing works
Tissue-Resident Memory T Cells in Tumor Immunity and Immunotherapy of Digestive System Tumors
Cheng, M., Liu, J., Liang, Y., Xu, J., Ma, L., & Liang, J. (2025) · Immunological Investigations · doi:10.1080/08820139.2024.2447780 · Cited by 3 · see citing works
Shi, L., Uzuni, A., Wang, X. K., Pressler, M., Harle, D. W., Chakrabarti, S., Macedo, R., Belay, K., Gordillo, C. A., McMahon-Skates, T., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02631-2 · Cited by 3 · see citing works
Multifaceted functions of tissue-resident memory T cells in tumorigenesis and cancer immunotherapy
Seo, E. S., Lee, S., & Son, Y. M. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04035-x · Cited by 3 · see citing works
scRNA ‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions
Meledathu, S., Kurowski, A., Naidu, M. P., Aðalsteinsson, J. A., Meehan, S. A., Alkon, N., Port, L. R., Chennareddy, S., Cohenour, E. R., Christensen, G., et al. (2025) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.70154 · Cited by 2 · see citing works
Guo, Y.-C., Wang, Y., Ding, G.-X., Wang, T., Sun, F.-Z., Ma, X., & Wu, J.-T. (2025) · BMC Cancer · doi:10.1186/s12885-025-14643-6 · Cited by 1 · see citing works
Xie, D., Tian, Y., Zhang, J., He, M., & Lu, L. W. A. G. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1014806 · Cited by 1 · see citing works
Tariq, F., Martin, P., Abacar, K., Ye, W., Sun, S., MacKay, S., Muldoon, D., Sharrack, S., Menon, M., Al‐Mossawi, H., et al. (2026) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2026.09.004 · Cited by 1 · see citing works
Go, Y., Uesugi, A., Lee, D., & Lim, S. B. (2026) · Scientific Data · doi:10.1038/s41597-026-07108-3 · Cited by 1 · see citing works
Zhang, W., Zhu, X., Wen, R., Wu, J., Zhou, L., Fan, H., Zhang, T., Li, Y., Liu, Z., Yu, G., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3909225/v1
AbdElneam, A. I., Al‐Dhubaibi, M. S., Bahaj, S. S., & Mohammed, G. F. (2024) · Human Gene · doi:10.1016/j.humgen.2024.201373
RetractedThe transcription factor ZNF683 marks an exhaustion-like GZMB+CD8+ T cell in sepsis
Hou, M., Mi, Z., Ouyang, S., Wang, W., Zhao, G., & Wang, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1756339
Valente, J. D., Marques, L. É. C., Mourão, R. M. D. S., Rodrigues, B. D. F. D. R., de SOUZA, L. S., da Silva, J. M. C., Casseb, S. M. M., Khayat, A. S., Demachki, S., Ishak, G., et al. (2026) · Microbes & Immunity · doi:10.36922/mi025510135
AbdElneam, A. I., Al‐Dhubaibi, M. S., Bahaj, S. S., Mohammed, G. F., & Atef, L. M. (2026) · Health Science Reports · doi:10.1002/hsr2.72699
T-LYMPHOCYTE SUBPOPULATIONS IN COLORECTAL CANCER
Mironov, A. A., Kryukova, V. V., & Львович, Ц. В. (2026) · Zabajkalʹskij medicinskij vestnik · doi:10.52485/19986173_2026_2_162
Song, J., Zhang, H., Zheng, Z., Shi, R., & Zhang, Q. (2026) · Discover Oncology · doi:10.1007/s12672-026-05765-9
Düzağaç, F., Deng, N., Wang, J., Nagaraju, S., Steinberger, P., Reuben, A., Sinha, K. M., & Vilar, E. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.103057
Wyatt, M. M., Mason, R., Carmouche, J., Ruffin, A. T., Wittling, M. C., Cole, A., Smith, A., Rivera, G. O. R., Ware, M., Lowe, M., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-11309475/v1
- Authors
- Kitakaze, M., Uemura, M., Hara, T., Chijimatsu, R., Motooka, D., Hirai, T., Konno, M., Okuzaki, D., Sekido, Y., Hata, T., Ogino, T., Takahashi, H., Miyoshi, N., Ofusa, K., Mizushima, T., Eguchi, H., Doki, Y., & Ishii, H.
- Affiliations
- The University of Osaka (JP)
- Center of Medical Innovation and Translational Research, The University of Osaka (JP)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- IDEA Consultants, Inc. (Japan) (JP)
- Corresponding author
- Ishii, Hideshi
- ORCID
- Venue
- British Journal of Cancer
- Published
- 2023-03-03
- Volume
- 128
- Issue
- 10
- Pages
- 1828-1837
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC10147592
- OpenAlex
- W4323043053
- Cited by
- 49
- References
- 48
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 13
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal of Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- OUKA (Osaka University Knowledge Archive) (Osaka University) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (20H00541, 18KK0251, 19K22658, 21K19526, 22H03146, 22K19559, 16H06279 (PAGS), 22H04925 (PAGS))
- Mitsubishi Foundation (2021)
- Japan Agency for Medical Research and Development (17cm0106414h0002, JP21lm0203007)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- tissue-resident memory T cells, colorectal cancer, tumor-infiltrating lymphocytes, prognostic factors, interferon-gamma signaling, T cell receptor signaling, T cell exhaustion, cancer immunotherapy targets
- MeSH terms
- Memory T Cells, Humans, Immunologic Memory, Prognosis, Transcription Factors, Colorectal Neoplasms, Lymphocytes, Tumor-Infiltrating, CD8-Positive T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
