Dixit, Vishwa Deep

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,655

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,172

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., et al. (2013) · Cell Metabolism

Inflammasome and immune disordersGenetics, Aging, and Longevity in Model Organisms

Cited by 674

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma

Johnson, J. B., Summer, W., Cutler, R. G., Martin, B., Hyun, D.-H., Dixit, V. D., Pearson, M., Nassar, M., Tellejohan, R., Maudsley, S., et al. (2007) · Free Radical Biology and Medicine

Dietary Effects on HealthAsthma and respiratory diseases

Cited by 604

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y.-H., Brown, C. W., Elsworth, J., et al. (2017) · Nature

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 456

Adipose tissue as an immunological organ

Grant, R. W., & Dixit, V. D. (2015) · Obesity

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 453

β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares

Goldberg, E. L., Asher, J. L., Molony, R. D., Shaw, A. C., Zeiss, C. J., Wang, C., Morozova-Roche, L. A., Herzog, R. I., Iwasaki, A., & Dixit, V. D. (2017) · Cell Reports

Inflammasome and immune disordersGout, Hyperuricemia, Uric Acid

Cited by 370

Caloric restriction in humans reveals immunometabolic regulators of health span

Spadaro, O., Youm, Y., Shchukina, I., Ryu, S., Sidorov, S., Ravussin, A., Nguyen, K., Aladyeva, E., Predeus, A. N., Smith, S. R., et al. (2022) · Science

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 317

Drivers of age‐related inflammation and strategies for healthspan extension

Goldberg, E. L., & Dixit, V. D. (2015) · Immunological Reviews

Inflammasome and immune disordersGenetics, Aging, and Longevity in Model Organisms

Cited by 274

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

Meydani, S. N., Das, S. K., Pieper, C. F., Lewis, M. R., Klein, S., Dixit, V. D., Gupta, A. K., Villareal, D. T., Bhapkar, M., Huang, M., et al. (2016) · Aging

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 228

Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution

Yang, H., Youm, Y.-H., & Dixit, V. D. (2009) · The Journal of Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 196

The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence

Youm, Y.-H., Kanneganti, T.-D., Vandanmagsar, B., Zhu, X., Ravussin, A., Adijiang, A., Owen, J. S., Thomas, M. J., Francis, J., Parks, J. S., et al. (2012) · Cell Reports

Inflammasome and immune disordersT-cell and B-cell Immunology

Cited by 172

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Youm, Y.-H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A., & Dixit, V. D. (2016) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyFibroblast Growth Factor Research

Cited by 129

Nlrp3 Inflammasome Activation in Type 2 Diabetes: Is It Clinically Relevant?

Dixit, V. D. (2013) · Diabetes

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 85

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

Camporez, J. P., Lyu, K., Goldberg, E. L., Zhang, D., Cline, G. W., Jurczak, M. J., Dixit, V. D., Petersen, K. F., & Shulman, G. I. (2019) · The Journal of Physiology

Adipokines, Inflammation, and Metabolic DiseasesEstrogen and related hormone effects

Cited by 71

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

Lee, A. H., Orliaguet, L., Youm, Y.-H., Maeda, R., Dlugos, T., Lei, Y., Coman, D., Shchukina, I., Andhey, P. S., Smith, S. R., et al. (2025) · Nature Metabolism

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 45

A review of the biomedical innovations for healthy longevity

Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V. D., Debonneuil, E., et al. (2017) · Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 22

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

Mishra, M., Kim, H.-H., Youm, Y.-H., Gonzalez-Hurtado, E., Zaitsev, K., Dlugos, T., Shchukina, I., Gliniak, C., Ravussin, E., Mohanty, S., et al. (2026) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsComplement system in diseases

Cited by 10