Campisi, Judith

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,160

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., & Campisi, J. (2003) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,116

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 1,046

p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype

Freund, A., Patil, C. K., & Campisi, J. (2011) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,039

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., Lu, T., Yankner, B. A., Campisi, J., & Elledge, S. J. (2015) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 982

Senescence and apoptosis: dueling or complementary cell fates?

Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J., & van Deursen, J. M. (2014) · The EMBO Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 915

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

Sun, Y., Campisi, J., Higano, C., Beer, T. M., Porter, P., Coleman, I., True, L., & Nelson, P. S. (2012) · Nature Medicine

Wnt/β-catenin signaling in development and cancerProstate Cancer Treatment and Research

Cited by 793

The metabolic roots of senescence: mechanisms and opportunities for intervention

Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 691

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceAdipokines, Inflammation, and Metabolic Diseases

Cited by 658

Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

Orjalo, A. V., Bhaumik, D., Gengler, B. K., Scott, G. K., & Campisi, J. (2009) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 654

Senescent cells as a source of inflammatory factors for tumor progression

Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 636

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

Parrinello, S., Coppe, J.-P., Krtolica, A., & Campisi, J. (2005) · Journal of Cell Science

Telomeres, Telomerase, and SenescenceTGF-β signaling in diseases

Cited by 631

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceAngiogenesis and VEGF in Cancer

Cited by 604

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Pereira, B. I., Devine, O. P., Vukmanovic-Stejic, M., Chambers, E. S., Subramanian, P., Patel, N., Virasami, A., Sebire, N. J., Kinsler, V., Valdovinos, A., et al. (2019) · Nature Communications

Telomeres, Telomerase, and SenescenceImmune Cell Function and Interaction

Cited by 556

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 553

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

Rodier, F., Muñoz, D. P., Teachenor, R., Chu, V., Le, O., Bhaumik, D., Coppé, J.-P., Campeau, E., Beauséjour, C. M., Kim, S.-H., et al. (2011) · Journal of Cell Science

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 535

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Chinta, S. J., Woods, G., Demaria, M., Rane, A., Zou, Y., McQuade, A., Rajagopalan, S., Limbad, C., Madden, D. T., Campisi, J., et al. (2018) · Cell Reports

Parkinson's Disease Mechanisms and TreatmentsTelomeres, Telomerase, and Senescence

Cited by 530

TIN2, a new regulator of telomere length in human cells

Kim, S.-H., Kaminker, P., & Campisi, J. (1999) · Nature Genetics

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 525

Cancer and ageing: rival demons?

Campisi, J. (2003) · Nature Reviews Cancer

Genetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

Cited by 512

Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 506

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Orjalo, A. V., Rodier, F., Lithgow, G. J., & Campisi, J. (2009) · Aging

Telomeres, Telomerase, and SenescenceMicroRNA in disease regulation

Cited by 500

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

Coppé, J.-P., Patil, C. K., Rodier, F., Krtolica, A., Beauséjour, C. M., Parrinello, S., Hodgson, J. G., Chin, K., Desprez, P.-Y., & Campisi, J. (2010) · PLoS ONE

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 455

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

Wiley, C. D., & Campisi, J. (2016) · Cell Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 440

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

Davalos, A. R., Kawahara, M., Malhotra, G. K., Schaum, N., Huang, J., Ved, U., Beausejour, C. M., Coppe, J.-P., Rodier, F., & Campisi, J. (2013) · Journal of Cell Biology

Telomeres, Telomerase, and SenescenceAdvanced Glycation End Products research

Cited by 439