Cited by 691Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

The metabolic roots of senescence: mechanisms and opportunities for intervention

Open access
Wiley, Christopher D., Campisi, Judith·2021·Nature Metabolism

Abstract

Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic changes. Among these changes is the release of numerous biologically active molecules collectively known as the senescence-associated secretory phenotype, or SASP. A growing body of literature indicates that both senescence and the SASP are sensitive to cellular and organismal metabolic states, which in turn can drive phenotypes associated with metabolic dysfunction. Here, we review the current literature linking senescence and metabolism, with an eye toward findings at the cellular level, including both metabolic inducers of senescence and alterations in cellular metabolism associated with senescence. Additionally, we consider how interventions that target either metabolism or senescent cells might influence each other and mitigate some of the pro-aging effects of cellular senescence. We conclude that the most effective interventions will likely break a degenerative feedback cycle by which cellular senescence promotes metabolic diseases, which in turn promote senescence.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s42255-021-00483-8

Cites

216 of 216 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • SASP composition and strength vary with senescence duration, stimulus origin, and cell type.

    “The composition and strength of the SASP can vary depending on the duration of senescence, the origin of the senescence stimulus and specific cell types17,21.”
  • Senescence is characterized by morphological and functional changes including enlarged cell size, nuclear changes, metabolic remodeling, and the SASP.

    “is characterized by morphological and functional changes, including enlarged cell size,9,10 nuclear changes,11,12,13,14,15 metabolic remodeling,16 and the SASP.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wiley, C. D., & Campisi, J.
Affiliations
  • Tufts University (US)
  • Buck Institute for Research on Aging (US)
Corresponding author
Wiley, Christopher D.
Venue
Nature Metabolism
Published
2021-10-18
Volume
3
Issue
10
Pages
1290-1301
ISSN
2522-5812 (ISSN-L)
OpenAlex
W3206142581
Cited by
691
References
216
Citations by year
2026: 144 · 2025: 191 · 2024: 163 · 2023: 121 · 2022: 69 · 2021: 2 · 2020: 1
FWCI
11.94
Type
journal article
Language
en
Open access
Locations
  • Nature Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • United States Department of Agriculture | Agricultural Research Service (8050-51000-099-01S)
  • U.S. Department of Health & Human Services | NIH | National Institute on Aging (AG051729)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
cellular senescence, senescence-associated secretory phenotype, cellular metabolism, metabolic dysfunction, senescence induction, senolytics, metabolic disorders, aging, proliferative arrest
MeSH terms
Animals, Autophagy, Homeostasis, Humans, Hyperglycemia, Lysosomes, Metals, NAD, Cellular Senescence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review