Sondek, John

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 1,697

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

Worthylake, D. K., Rossman, K. L., & Sondek, J. (2000) · Nature

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 355

A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange

Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L., & Sondek, J. (2002) · The EMBO Journal

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 222

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., & Sondek, J. (2002) · Nature Structural Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 209

The Phospholipase C Isozymes and Their Regulation

Gresset, A., Sondek, J., & Harden, T. K. (2012) · Subcellular Biochemistry

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 196

A Steric-Inhibition Model for Regulation of Nucleotide Exchange via the Dock180 Family of GEFs

Lu, M., Kinchen, J. M., Rossman, K. L., Grimsley, C., Hall, M., Sondek, J., Hengartner, M. O., Yajnik, V., & Ravichandran, K. S. (2005) · Current Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 102

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

Karnoub, A. E., Worthylake, D. K., Rossman, K. L., Pruitt, W. M., Campbell, S. L., Sondek, J., & Der, C. J. (2001) · Nature Structural Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 93

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Hajicek, N., Keith, N. C., Siraliev-Perez, E., Temple, B. R., Huang, W., Zhang, Q., Harden, T. K., & Sondek, J. (2019) · eLife

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 89

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

Tsai, A. P., Dong, C., Lin, P. B.-C., Oblak, A. L., Viana Di Prisco, G., Wang, N., Hajicek, N., Carr, A. J., Lendy, E. K., Hahn, O., et al. (2023) · Immunity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 71

SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC

Hamel, B., Monaghan-Benson, E., Rojas, R. J., Temple, B. R. S., Marston, D. J., Burridge, K., & Sondek, J. (2011) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 64

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways

Azoitei, M. L., Noh, J., Marston, D. J., Roudot, P., Marshall, C. B., Daugird, T. A., Lisanza, S. L., Sandí, M.-J., Ikura, M., Sondek, J., et al. (2019) · Journal of Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 61

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif

Yohe, M. E., Rossman, K. L., Gardner, O. S., Karnoub, A. E., Snyder, J. T., Gershburg, S., Graves, L. M., Der, C. J., & Sondek, J. (2007) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 45

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

Siraliev-Perez, E., Stariha, J. T., Hoffmann, R. M., Temple, B. R., Zhang, Q., Hajicek, N., Jenkins, M. L., Burke, J. E., & Sondek, J. (2022) · eLife

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 18

PLCG2 as a Risk Factor for Alzheimer's Disease.

Tsai, A. P., Dong, C., Preuss, C., Moutinho, M., Lin, P. B.-C., Hajicek, N., Sondek, J., Bissel, S. J., Oblak, A. L., Carter, G. W., et al. (2020)

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7