GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Abstract
Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AKAP13 is a Rho-family GEF that shares the same C1-DH-PH domain organization as GEFH1.
“A-kinase anchoring protein 13 (AKAP13, also known as AKAP-Lbc) is a Rho-family GEF that shares the same C1-DH-PH domain organization as GEFH1.”
From Structural basis of microtubule-mediated signal transduction (2026) · cites this paper as [88]
Cites
Krendel, M., Zenke, F. T., & Bokoch, G. M. (2002) · Nature Cell Biology · doi:10.1038/ncb773 · Cited by 669 · see citing works
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A.-C., Macara, I. G., Madhani, H., Fink, G. R., & Ravichandran, K. S. (2002) · Nature Cell Biology · doi:10.1038/ncb824 · Cited by 576 · see citing works
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
Worthylake, D. K., Rossman, K. L., & Sondek, J. (2000) · Nature · doi:10.1038/35047014 · Cited by 355 · see citing works
Self-citationZizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins
Meller, N., Irani-Tehrani, M., Kiosses, W. B., Del Pozo, M. A., & Schwartz, M. A. (2002) · Nature Cell Biology · doi:10.1038/ncb835 · Cited by 171 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ras history: The saga continues
Cox, A. D., & Der, C. J. (2010) · Small GTPases · doi:10.4161/sgtp.1.1.12178 · Cited by 706 · see citing works
Self-citationCook, D. R., Rossman, K. L., & Der, C. J. (2014) · Oncogene · doi:10.1038/onc.2013.362 · Cited by 378 · see citing works
Self-citationPhosphoinositides in Control of Membrane Dynamics
Schink, K. O., Tan, K.-W., & Stenmark, H. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125349 · Cited by 283 · see citing works
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273 · see citing works
Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
Margolis, S. S., Salogiannis, J., Lipton, D. M., Mandel-Brehm, C., Wills, Z. P., Mardinly, A. R., Hu, L., Greer, P. L., Bikoff, J. B., Ho, H.-Y. H., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.038 · Cited by 256 · see citing works
Dlx transcription factors promote migration through repression of axon and dendrite growth
Cobos, I., Borello, U., & Rubenstein, J. L. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.024 · Cited by 246 · see citing works
Peng, M., Yin, N., & Li, M. O. (2014) · Cell · doi:10.1016/j.cell.2014.08.038 · Cited by 220 · see citing works
Nalbant, P., Chang, Y.-C., Birkenfeld, J., Chang, Z.-F., & Bokoch, G. M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0041 · Cited by 148 · see citing works
Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor
Yang, J., Zhang, Z., Roe, S. M., Marshall, C. J., & Barford, D. (2009) · Science · doi:10.1126/science.1174468 · Cited by 123 · see citing works
WGEF activates Rho in the Wnt–PCP pathway and controls convergent extension in Xenopus gastrulation
Tanegashima, K., Zhao, H., & Dawid, I. B. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.9 · Cited by 121 · see citing works
RhoA Signaling in Neurodegenerative Diseases
Schmidt, S. I., Blaabjerg, M., Freude, K., & Meyer, M. (2022) · Cells · doi:10.3390/cells11091520 · Cited by 110 · see citing works
Canonical and non-canonical Reelin signaling
Bock, H. H., & May, P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00166 · Cited by 107 · see citing works
Chen, S.-Y., Huang, P.-H., & Cheng, H.-J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018128108 · Cited by 73 · see citing works
Kong, M., Bui, T. V., Ditsworth, D., Gruber, J. J., Goncharov, D., Krymskaya, V. P., Lindsten, T., & Thompson, C. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703159200 · Cited by 43 · see citing works
Amado-Azevedo, J., Valent, E. T., & Van Nieuw Amerongen, G. P. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1828-6 · Cited by 36 · see citing works
Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors
Kwofie, M. A., & Skowronski, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705170200 · Cited by 36 · see citing works
Xu, X., Omelchenko, T., & Hall, A. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-77 · Cited by 33 · see citing works
Hypoxia suppresses myofibroblast differentiation by changing RhoA activity
Leinhos, L., Peters, J., Krull, S., Helbig, L., Vogler, M., Levay, M., van Belle, G. J., Ridley, A. J., Lutz, S., Katschinski, D. M., et al. (2019) · Journal of Cell Science · doi:10.1242/jcs.223230 · Cited by 30 · see citing works
Structural basis of microtubule-mediated signal transduction
Choi, S. R., Blum, T. B., Giono, M., Roy, B., Vakonakis, I., Schmid, D., Oelgarth, N., Ranganathan, A., Gossert, A. D., Shivashankar, G. V., et al. (2026) · Cell · doi:10.1016/j.cell.2025.11.011 · Cited by 14 · see citing works
- Authors
- Rossman, K. L., Der, C. J., & Sondek, J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Der, Channing J.
- Sondek, John
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2005-02
- Volume
- 6
- Issue
- 2
- Pages
- 167-180
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2146473598
- Cited by
- 1,697
- References
- 4
- Citations by year
- 2026: 39 · 2025: 33 · 2024: 47 · 2023: 58 · 2022: 54 · 2021: 56 · 2020: 61 · 2019: 61 · 2018: 53 · 2017: 72 · 2016: 88 · 2015: 67 · 2014: 115 · 2013: 128 · 2012: 119
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- guanine nucleotide exchange factor, Rho GTPases, Rho GTPase activation, signal transduction, cell proliferation, cell differentiation, cell motility, human disease
- MeSH terms
- Allosteric Site, Animals, Humans, Lipid Bilayers, Models, Biological, Models, Molecular, Neurons, Phylogeny, Protein Binding, Signal Transduction, Protein Structure, Tertiary, Guanine Nucleotide Exchange Factors, ras-GRF1, rho GTP-Binding Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
