Pelletier, Jerry

Targeting the translation machinery in cancer

Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., & Topisirovic, I. (2015) · Nature Reviews Drug Discovery

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 799

Statistical practice in high-throughput screening data analysis

Malo, N., Hanley, J. A., Cerquozzi, S., Pelletier, J., & Nadon, R. (2006) · Nature Biotechnology

Computational Drug Discovery MethodsCell Image Analysis Techniques

Cited by 721

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Wolfe, A. L., Singh, K., Zhong, Y., Drewe, P., Rajasekhar, V. K., Sanghvi, V. R., Mavrakis, K. J., Jiang, M., Roderick, J. E., Van der Meulen, J., et al. (2014) · Nature

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 635

Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency

Pelletier, J., & Sonenberg, N. (1985) · Cell

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 610

Dissecting eIF4E action in tumorigenesis

Wendel, H.-G., Silva, R. L. A., Malina, A., Mills, J. R., Zhu, H., Ueda, T., Watanabe-Fukunaga, R., Fukunaga, R., Teruya-Feldstein, J., Pelletier, J., et al. (2007) · Genes & Development

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 487

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

Pelletier, J., Graff, J., Ruggero, D., & Sonenberg, N. (2015) · Cancer Research

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 367

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

Cencic, R., Carrier, M., Galicia-Vázquez, G., Bordeleau, M.-E., Sukarieh, R., Bourdeau, A., Brem, B., Teodoro, J. G., Greger, H., Tremblay, M. L., et al. (2009) · PLoS ONE

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 302

mTORC1 promotes survival through translational control of Mcl-1

Mills, J. R., Hippo, Y., Robert, F., Chen, S. M. H., Malina, A., Lin, C.-J., Trojahn, U., Wendel, H.-G., Charest, A., Bronson, R. T., et al. (2008) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerCell death mechanisms and regulation

Cited by 285

High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay

Hamdan, F. F., Audet, M., Garneau, P., Pelletier, J., & Bouvier, M. (2005) · SLAS Discovery

Receptor Mechanisms and Signalingbioluminescence and chemiluminescence research

Cited by 183

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

Lin, C.-J., Cencic, R., Mills, J. R., Robert, F., & Pelletier, J. (2008) · Cancer Research

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 180

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

Schatz, J. H., Oricchio, E., Wolfe, A. L., Jiang, M., Linkov, I., Maragulia, J., Shi, W., Zhang, Z., Rajasekhar, V. K., Pagano, N. C., et al. (2011) · Journal of Experimental Medicine

PI3K/AKT/mTOR signaling in cancerLymphoma Diagnosis and Treatment

Cited by 119

Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage

Cencic, R., Miura, H., Malina, A., Robert, F., Ethier, S., Schmeing, T. M., Dostie, J., & Pelletier, J. (2014) · PLoS ONE

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 117

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

Chan, K., Robert, F., Oertlin, C., Kapeller-Libermann, D., Avizonis, D., Gutierrez, J., Handly-Santana, A., Doubrovin, M., Park, J., Schoepfer, C., et al. (2019) · Nature Communications

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 106

Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies

Rodrigo, C. M., Cencic, R., Roche, S. P., Pelletier, J., & Porco, J. A. (2012) · Journal of Medicinal Chemistry

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 99

Altering chemosensitivity by modulating translation elongation

Robert, F., Carrier, M., Rawe, S., Chen, S., Lowe, S., & Pelletier, J. (2009) · PLoS ONE

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 90

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

Chu, J., Zhang, W., Cencic, R., Devine, W. G., Beglov, D., Henkel, T., Brown, L. E., Vajda, S., Porco, J. A., & Pelletier, J. (2019) · Cell Chemical Biology

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 74

Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma

Robert, F., Roman, W., Bramoullé, A., Fellmann, C., Roulston, A., Shustik, C., Porco, J. A., Shore, G. C., Sebag, M., & Pelletier, J. (2014) · Proceedings of the National Academy of Sciences

Multiple Myeloma Research and TreatmentsRNA and protein synthesis mechanisms

Cited by 64

The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

Moustafa-Kamal, M., Kucharski, T. J., El-Assaad, W., Abbas, Y. M., Gandin, V., Nagar, B., Pelletier, J., Topisirovic, I., & Teodoro, J. G. (2020) · Cell Reports

PI3K/AKT/mTOR signaling in cancerMicrotubule and mitosis dynamics

Cited by 31

Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse

Sénéchal, P., Robert, F., Cencic, R., Yanagiya, A., Chu, J., Sonenberg, N., Paquet, M., & Pelletier, J. (2021) · Cellular and Molecular Life Sciences

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 20