Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

The landscape of somatic copy-number alteration across human cancers

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eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Phosphorylation and Functional Inactivation of TSC2 by Erk

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mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

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The c-Myc target gene network

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

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Translational control in cancer

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S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

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Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP

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Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

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Bidirectional RNA Helicase Activity of Eucaryotic Translation Initiation Factors 4A and 4F

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Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF‐4A.

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Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

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The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection.Preprint

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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.

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Rearrangement of MYC Is Associated With Poor Prognosis in Patients With Diffuse Large B-Cell Lymphoma Treated in the Era of Rituximab

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The Molecular Mechanics of Eukaryotic Translation

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

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Dissecting eIF4E action in tumorigenesis.Preprint

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Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

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Mnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development

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Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.

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The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation

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Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

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The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure

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Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo

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Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

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Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

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Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes.

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Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.

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Principles of Translational Control: An OverviewPreprint

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Structure of translation factor elF4E bound to m7GDP and interaction with 4E-binding protein

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A common function for mRNA 5' and 3' ends in translation initiation in yeast.Preprint

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eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

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Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A

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Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

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Modulation of the Helicase Activity of eIF4A by eIF4B, eIF4H, and eIF4F

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Biochemical and Kinetic Characterization of the RNA Helicase Activity of Eukaryotic Initiation Factor 4A

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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

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Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

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L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia

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Osteopontin: regulation in tumor metastasis

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Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

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Prevalence, predictive factors, and screening for psychologic distress in patients with newly diagnosed head and neck cancer

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Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

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A Novel Functional Human Eukaryotic Translation Initiation Factor 4G

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Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A

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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

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Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

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4E-Binding Protein 1: A Key Molecular “Funnel Factor” in Human Cancer with Clinical Implications

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Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities

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Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

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Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

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Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5′TOP mRNA translationPreprint

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Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2

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Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation

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Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

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Translational control of immune responses: from transcripts to translatomes

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eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure

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An Essential E Box in the Promoter of the Gene Encoding the mRNA Cap-Binding Protein (Eukaryotic Initiation Factor 4E) Is a Target for Activation by c-myc

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