Passos, João F.

Cellular senescence: all roads lead to mitochondria

Martini, H., & Passos, J. F. (2023) · The FEBS Journal

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 334

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

Chapman, J., Fielder, E., & Passos, J. F. (2019) · FEBS Letters

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 325

Stress, cell senescence and organismal ageing

de Magalhães, J. P., & Passos, J. F. (2018) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 316

Cytoplasmic DNA: sources, sensing, and role in aging and disease

Miller, K. N., Victorelli, S. G., Salmonowicz, H., Dasgupta, N., Liu, T., Passos, J. F., & Adams, P. D. (2021) · Cell

interferon and immune responsesImmune Response and Inflammation

Cited by 288

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Victorelli, S., Lagnado, A., Halim, J., Moore, W., Talbot, D., Barrett, K., Chapman, J., Birch, J., Ogrodnik, M., Meves, A., et al. (2019) · The EMBO Journal

Telomeres, Telomerase, and SenescenceSkin Protection and Aging

Cited by 258

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

Walaszczyk, A., Dookun, E., Redgrave, R., Tual‐Chalot, S., Victorelli, S., Spyridopoulos, I., Owens, A., Arthur, H. M., Passos, J. F., & Richardson, G. D. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceCardiac Fibrosis and Remodeling

Cited by 250

Quantitative assessment of markers for cell senescence

Lawless, C., Wang, C., Jurk, D., Merz, A., Zglinicki, T. V., & Passos, J. F. (2010) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 240

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., et al. (2021) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 211

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Iske, J., Seyda, M., Heinbokel, T., Maenosono, R., Minami, K., Nian, Y., Quante, M., Falk, C. S., Azuma, H., Martin, F., et al. (2020) · Nature Communications

Telomeres, Telomerase, and SenescenceTransplantation: Methods and Outcomes

Cited by 211

Characterization of cellular senescence in aging skeletal muscle

Zhang, X., Habiballa, L., Aversa, Z., Ng, Y. E., Sakamoto, A. E., Englund, D. A., Pearsall, V. M., White, T. A., Robinson, M. M., Rivas, D. A., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceMuscle Physiology and Disorders

Cited by 206

Reducing Senescent Cell Burden in Aging and Disease

Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T., & Kirkland, J. L. (2020) · Trends in Molecular Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 177

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

Birch, J., Anderson, R. K., Correia-Melo, C., Jurk, D., Hewitt, G., Marques, F. M., Green, N. J., Moisey, E., Birrell, M. A., Belvisi, M. G., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Telomeres, Telomerase, and SenescenceChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 174

Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery

Dookun, E., Walaszczyk, A., Redgrave, R., Palmowski, P., Tual‐Chalot, S., Suwana, A., Chapman, J., Jirkovsky, E., Donastorg Sosa, L., Gill, E., et al. (2020) · Aging Cell

Cardiac Ischemia and ReperfusionTelomeres, Telomerase, and Senescence

Cited by 173

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

Wilson, C. L., Jurk, D., Fullard, N., Banks, P., Page, A., Luli, S., Elsharkawy, A. M., Gieling, R. G., Chakraborty, J. B., Fox, C., et al. (2015) · Nature Communications

Immune cells in cancerHepatocellular Carcinoma Treatment and Prognosis

Cited by 171

Mitochondria: Are they causal players in cellular senescence?

Correia-Melo, C., & Passos, J. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 160

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Hari, P., Millar, F. R., Tarrats, N., Birch, J., Quintanilla, A., Rink, C. J., Fernández-Duran, I., Muir, M., Finch, A. J., Brunton, V. G., et al. (2019) · Science Advances

Telomeres, Telomerase, and SenescenceImmune Response and Inflammation

Cited by 154

Spatial mapping of cellular senescence: emerging challenges and opportunities

Gurkar, A. U., Gerencser, A. A., Mora, A. L., Nelson, A. C., Zhang, A. R., Lagnado, A. B., Enninful, A., Benz, C., Furman, D., Beaulieu, D., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 141

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F., et al. (2020) · Journal of Bone and Mineral Research

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 138

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

Eckhardt, B. A., Rowsey, J. L., Thicke, B. S., Fraser, D. G., O’Grady, K. L., Bondar, O. P., Hines, J. M., Singh, R. J., Thoreson, A. R., Rakshit, K., et al. (2020) · JCI Insight

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 130

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism

Telomeres, Telomerase, and SenescenceNeurogenesis and neuroplasticity mechanisms

Cited by 125

Oxygen free radicals in cell senescence: Are they signal transducers?

Passos, J. F., & Von Zglinicki, T. (2006) · Free Radical Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Targeted clearance of p21 ‐ but not p16 ‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Chandra, A., Lagnado, A. B., Farr, J. N., Doolittle, M., Tchkonia, T., Kirkland, J. L., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 120

Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence

Ogrodnik, M., Salmonowicz, H., Jurk, D., & Passos, J. F. (2019) · Trends in Biochemical Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 104