Passos, João F.

Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

Birch, J., & Passos, J. F. (2017) · BioEssays

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 89

Mitochondria and cellular senescence: Implications for musculoskeletal ageing

Habiballa, L., Salmonowicz, H., & Passos, J. F. (2019) · Free Radical Biology and Medicine

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 82

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice

Correia‐Melo, C., Birch, J., Fielder, E., Rahmatika, D., Taylor, J., Chapman, J., Lagnado, A., Carroll, B. M., Miwa, S., Richardson, G., et al. (2019) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 77

Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice

Fielder, E., Tweedy, C., Wilson, C., Oakley, F., LeBeau, F. E. N., Passos, J. F., Mann, D. A., von Zglinicki, T., & Jurk, D. (2020) · Aging Cell

Neuroinflammation and Neurodegeneration MechanismsAntioxidants, Aging, Portulaca oleracea

Cited by 71

Therapeutic Potential of Senolytics in Cardiovascular Disease

Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D. (2022) · Cardiovascular Drugs and Therapy

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 69

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

Lawless, C., Jurk, D., Gillespie, C. S., Shanley, D., Saretzki, G., von Zglinicki, T., & Passos, J. F. (2012) · PLoS ONE

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 62

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology

Cardiovascular Health and Disease PreventionTelomeres, Telomerase, and Senescence

Cited by 59

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456

Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2020) · EBioMedicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 59

Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis

Bianchi, A., Marchetti, L., Hall, Z., Lemos, H., Vacca, M., Paish, H., Green, K., Elliott, B., Tiniakos, D., Passos, J. F., et al. (2021) · The Journal of Immunology

Exercise and Physiological ResponsesSirtuins and Resveratrol in Medicine

Cited by 45

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Han, Y., Zhang, X., Franco, A. C., Kim, S. Y., Wyles, S. P., Prakash, Y. S., et al. (2025) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 45

Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis

Birch, J., Victorelli, S., Rahmatika, D., Anderson, R. K., Jiwa, K., Moisey, E., Ward, C., Fisher, A. J., Soyza, A. D., & Passos, J. F. (2016) · American Journal of Respiratory and Critical Care Medicine

Telomeres, Telomerase, and SenescenceCystic Fibrosis Research Advances

Cited by 44

Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma

Aghali, A., Khalfaoui, L., Lagnado, A. B., Drake, L. Y., Teske, J. J., Pabelick, C. M., Passos, J. F., & Prakash, Y. S. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Telomeres, Telomerase, and SenescenceAsthma and respiratory diseases

Cited by 44

Advancing biological understanding of cellular senescence with computational multiomics

Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 40

Distinct secretomes in p16- and p21- positive senescent cells across tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Monroe, D. G., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Khosla, S., & Passos, J. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 28

The relationship between the aging- and photo-dependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts

Birket, M. J., Passos, J. F., von Zglinicki, T., & Birch-Machin, M. A. (2009) · Journal of Investigative Dermatology

Mitochondrial Function and PathologyTelomeres, Telomerase, and Senescence

Cited by 24

ssDNA fragments induce cell senescence by telomere uncapping

Tsolou, A., Passos, J. F., Nelson, G., Arai, Y., & Zglinicki, T. V. (2008) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 18

Demystifying the role of mitochondria in senescence

Correia-Melo, C., & Passos, J. F. (2016) · Molecular & Cellular Oncology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 5