Therapeutic Potential of Senolytics in Cardiovascular Disease
Open accessAbstract
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is associated with both an increased prevalence of cardiovascular disease including heart failure, coronary artery disease, and myocardial infarction. Furthermore, ageing is associated with a poorer prognosis to these diseases. Genetic models allowing the elimination of senescent cells revealed that an accumulation of senescence contributes to the pathophysiology of cardiovascular ageing and promotes the progression of cardiovascular disease through the expression of a proinflammatory and profibrotic senescence-associated secretory phenotype. These studies have resulted in an effort to identify pharmacological therapeutics that enable the specific elimination of senescent cells through apoptosis induction. These senescent cell apoptosis-inducing compounds are termed senolytics and their potential to ameliorate age-associated cardiovascular disease is the focus of this review.
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Beside antioxidant activity, flavonoids have anti-inflammatory, vasodilator, anticoagulant, cardioprotective, anti-diabetic, neuroprotective, and anti-obesity activities, making them of interest as anti-aging compounds.
“Beside the antioxidant activity, flavonoids have anti-inflammatory, vasodilator, anticoagulant, cardioprotective, anti-diabetic, neuroprotective, and anti-obesity activities, which make them of great interest as anti-aging compounds (Table 3) [228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [234]
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- Authors
- Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D.
- Affiliations
- Newcastle University (GB)
- Mayo Clinic (US)
- Corresponding author
- Richardson, Gavin D.
- Venue
- Cardiovascular Drugs and Therapy
- Published
- 2020-09-26
- Volume
- 36
- Issue
- 1
- Pages
- 187-196
- ISSN
- 0920-3206 (ISSN-L)
- 1573-7241
- PMC
- PMC8770386
- OpenAlex
- W3089255423
- Cited by
- 69
- References
- 98
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 8 · 2023: 16 · 2022: 8 · 2021: 16 · 2020: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cardiovascular Drugs and Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- British Heart Foundation (PG/19/15/34269)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- senolytics, senescence-associated secretory phenotype, cellular senescence, cardiovascular aging, cardiovascular disease, heart failure, coronary artery disease, myocardial infarction, apoptosis induction
- MeSH terms
- Senescence-Associated Secretory Phenotype, Senotherapeutics, Aged, Aging, Animals, Cardiovascular Diseases, Humans, Prognosis, Risk Factors, Cellular Senescence, Apoptosis, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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