Sixma, Titia K.

A genomic and functional inventory of deubiquitinating enzymes.

Nijman, S. M. B., Luna-Vargas, M. P. A., Velds, A., Brummelkamp, T. R., Dirac, A. M. G., Sixma, T. K., & Bernards, R. (2005) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

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AI revolutions in biology: The joys and perils of AlphaFold

Perrakis, A., & Sixma, T. K. (2021) · The EMBO Reports

Protein Structure and DynamicsMachine Learning in Bioinformatics

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Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

Kim, R. Q., Geurink, P. P., Mulder, M. P. C., Fish, A., Ekkebus, R., El Oualid, F., van Dijk, W. J., van Dalen, D., Ovaa, H., van Ingen, H., et al. (2019) · Nature Communications

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

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The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics

Llerena Schiffmacher, D. A., Lee, S.-H., Kliza, K. W., Theil, A. F., Akita, M., Helfricht, A., Bezstarosti, K., Gonzalo-Hansen, C., van Attikum, H., Verlaan-de Vries, M., et al. (2024) · Nature Communications

DNA Repair MechanismsUbiquitin and proteasome pathways

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DDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II

Pines, A., Schiffmacher, D. L., Lee, S.-H., Kliza, K., Theil, A., Akita, M., Helfricht, A., Bezstarosti, K., Gonzalo-Hansen, C., Attikum, H. V., et al. (2023) · Nature Communications

DNA Repair MechanismsUbiquitin and proteasome pathways

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