McMahon, Martin

BrafV600E cooperates with Pten loss to induce metastatic melanoma

Dankort, D., Curley, D. P., Cartlidge, R. A., Nelson, B., Karnezis, A. N., Damsky Jr, W. E., You, M. J., DePinho, R. A., McMahon, M., & Bosenberg, M. (2009) · Nature Genetics

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

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Senescence of human fibroblasts induced by oncogenic Raf

Zhu, J., Woods, D., McMahon, M., & Bishop, J. M. (1998) · Genes & Development

Telomeres, Telomerase, and SenescenceProtein Kinase Regulation and GTPase Signaling

Cited by 826

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

Das Thakur, M., Salangsang, F., Landman, A. S., Sellers, W. R., Pryer, N. K., Levesque, M. P., Dummer, R., McMahon, M., & Stuart, D. D. (2013) · Nature

Melanoma and MAPK PathwaysLung Cancer Treatments and Mutations

Cited by 730

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Kinsey, C. G., Camolotto, S. A., Boespflug, A. M., Guillen, K. P., Foth, M., Truong, A., Schuman, S. S., Shea, J. E., Seipp, M. T., Yap, J. T., et al. (2019) · Nature Medicine

Autophagy in Disease and TherapyProtein Kinase Regulation and GTPase Signaling

Cited by 634

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

Lin, L., Sabnis, A. J., Chan, E., Olivas, V., Cade, L., Pazarentzos, E., Asthana, S., Neel, D., Yan, J. J., Lu, X., et al. (2015) · Nature Genetics

Hippo pathway signaling and YAP/TAZMelanoma and MAPK Pathways

Cited by 551

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

Mitra, D., Luo, X., Morgan, A., Wang, J., Hoang, M. P., Lo, J., Guerrero, C. R., Lennerz, J. K., Mihm, M. C., Wargo, J. A., et al. (2012) · Nature

Melanoma and MAPK Pathwaysmelanin and skin pigmentation

Cited by 497

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of Braf V600E–Driven Lung Tumors

Strohecker, A. M., Guo, J. Y., Karsli-Uzunbas, G., Price, S. M., Chen, G. J., Mathew, R., McMahon, M., & White, E. (2013) · Cancer Discovery

Autophagy in Disease and TherapyCancer, Hypoxia, and Metabolism

Cited by 435

Opposing Effects of Ras on p53

Ries, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., & McCormick, F. (2000) · Cell

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 357

Elucidating Distinct Roles for NF1 in Melanomagenesis

Maertens, O., Johnson, B., Hollstein, P., Frederick, D. T., Cooper, Z. A., Messiaen, L., Bronson, R. T., McMahon, M., Granter, S., Flaherty, K., et al. (2013) · Cancer Discovery

Melanoma and MAPK PathwaysNeurofibromatosis and Schwannoma Cases

Cited by 258

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Bergo, M. O., Gavino, B. J., Hong, C., Beigneux, A. P., McMahon, M., Casey, P. J., & Young, S. G. (2004) · Journal of Clinical Investigation

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 180

mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation

Damsky, W., Micevic, G., Meeth, K., Muthusamy, V., Curley, D. P., Santhanakrishnan, M., Erdelyi, I., Platt, J. T., Huang, L., Theodosakis, N., et al. (2015) · Cancer Cell

Melanoma and MAPK PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 142

PI3′-Kinase Inhibition Forestalls the Onset of MEK1/2 Inhibitor Resistance in BRAF -Mutated Melanoma

Deuker, M. M., Marsh Durban, V., Phillips, W. A., & McMahon, M. (2015) · Cancer Discovery

Melanoma and MAPK PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 60

PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis

Green, S., Trejo, C. L., & McMahon, M. (2015) · Cancer Research

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 38

Inhibition of MEK1/2 forestalls the onset of acquired resistance to entrectinib in multiple models of NTRK1-driven cancer

Vaishnavi, A., Scherzer, M. T., Kinsey, C. G., Parkman, G. L., Truong, A., Ghazi, P., Schuman, S., Battistone, B., Garrido-Laguna, I., & McMahon, M. (2020) · Cell Reports

Melanoma and MAPK PathwaysLung Cancer Treatments and Mutations

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