Opposing Effects of Ras on p53

p53 Mutations in Human Cancers

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

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Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

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Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

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Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

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Signaling to p53

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Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

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p19ARF links the tumour suppressor p53 to Ras

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E1A signaling to p53 involves the p19ARFtumor suppressorPreprint

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

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K-ras is an essential gene in the mouse with partial functional overlap with N-rasPreprint

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P19 ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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Untitled work

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

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The ras Oncogenes Increase the Intrinsic Resistance of NIH 3T3 Cells to Ionizing Radiation

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Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

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Conditional Transformation of Cells and Rapid Activation of the Mitogen-Activated Protein Kinase Cascade by An Estradiol-Dependent Human Raf-1 Protein Kinase

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Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

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MDM2-arbiter of p53's destruction

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Insulin-Like Growth Factor-1 Induces Mdm2 and Down-Regulates p53, Attenuating the Myocyte Renin-Angiotensin System and Stretch-Mediated Apoptosis

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N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation.

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c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

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Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

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