Aarons, Leon

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Margolskee, A., Darwich, A. S., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 69

Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach

Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A., & Aarons, L. (2014) · Clinical Pharmacology & Therapeutics

Pharmacogenetics and Drug MetabolismLipoproteins and Cardiovascular Health

Cited by 68

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A., & Aarons, L. (2015) · Pharmaceutical Research

Pharmacogenetics and Drug MetabolismPharmaceutical studies and practices

Cited by 64

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Darwich, A. S., Margolskee, A., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsComputational Drug Discovery Methods

Cited by 45

IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Margolskee, A., Darwich, A. S., Pepin, X., Pathak, S. M., Bolger, M. B., Aarons, L., Rostami-Hodjegan, A., Angstenberger, J., Graf, F., Laplanche, L., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 43

Modeling and Simulation for Clinical Trial Design Involving a Categorical Response: A Phase II Case Study with Naratriptan

Nestorov, I., Graham, G., Duffull, S., Aarons, L., Fuseau, E., & Coates, P. (2001) · Pharmaceutical Research

Statistical Methods in Clinical TrialsPharmaceutical studies and practices

Cited by 41

Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

Hansmann, S., Darwich, A., Margolskee, A., Aarons, L., & Dressman, J. (2016) · Journal of Pharmacy and Pharmacology

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 38

Uncertainty Analysis in Pharmacokinetics and Pharmacodynamics: Application to Naratriptan

Gueorguieva, I., Nestorov, I. A., Aarons, L., & Rowland, M. (2005) · Pharmaceutical Research

Migraine and Headache StudiesStatistical Methods in Clinical Trials

Cited by 18