Luthey-Schulten, Zaida

THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective

Onuchic, J. N., Luthey-Schulten, Z., & Wolynes, P. G. (1997) · Annual Review of Physical Chemistry

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 2,210

Toward an outline of the topography of a realistic protein-folding funnel.

Onuchic, J. N., Wolynes, P. G., Luthey-Schulten, Z., & Socci, N. D. (1995) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 523

Essential metabolism for a minimal cell

Breuer, M., Earnest, E. E., Merryman, C., Wise, K. S., Sun, L., Lynott, M. R., Hutchison, C. A., Smith, H. O., Lapek, J. D., Gonzalez, D. J., et al. (2019) · eLife

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 190

Fundamental behaviors emerge from simulations of a living minimal cell

Thornburg, Z. R., Bianchi, D. M., Brier, T. A., Gilbert, B. R., Earnest, E. E., Melo, M. C. R., Safronova, N., Sáenz, J. P., Cook, A. T., Wise, K. S., et al. (2022) · Cell

Lipid Membrane Structure and BehaviorLipid metabolism and biosynthesis

Cited by 165

Molecular dynamics simulation of an entire cell

Stevens, J. A., Grünewald, F., van Tilburg, P. A. M., König, M., Gilbert, B. R., Brier, T. A., Thornburg, Z. R., Luthey-Schulten, Z., & Marrink, S. J. (2023) · Frontiers in Chemistry

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 156

Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population

Labhsetwar, P., Cole, J. A., Roberts, E., Price, N. D., & Luthey-Schulten, Z. A. (2013) · Proceedings of the National Academy of Sciences

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 94

Effects of DNA replication on mRNA noise

Peterson, J. R., Cole, J. A., Fei, J., Ha, T., & Luthey-Schulten, Z. A. (2015) · Proceedings of the National Academy of Sciences

Gene Regulatory Network Analysisstochastic dynamics and bifurcation

Cited by 46

Bringing the genetically minimal cell to life on a computer in 4D

Thornburg, Z. R., Maytin, A., Kwon, J., Brier, T. A., Gilbert, B. R., Fu, E., Gao, Y.-L., Quenneville, J., Wu, T., Li, H., et al. (2026) · Cell

Gene Regulatory Network AnalysisRNA and protein synthesis mechanisms

Cited by 44

Bringing the Genetically Minimal Cell to Life on a Computer in 4D

Thornburg, Z. R., Maytin, A., Kwon, J., Brier, T. A., Gilbert, B. R., Fu, E., Gao, Y.-L., Quenneville, J., Wu, T., Li, H., et al. (2025) · Cell

Gene Regulatory Network AnalysisRNA and protein synthesis mechanisms

Cited by 44

‘Integrating experiments, theory and simulations into whole-cell models’

Luthey-Schulten, Z. (2021) · Nature Methods

Gene Regulatory Network AnalysisPhilosophy of Biology and Scientific Explanation

Cited by 39

‘Generating chromosome geometries in a minimal cell from cryo-electron tomograms and chromosome conformation capture maps’

Gilbert, B. R., Thornburg, Z. R., Lam, V., Rashid, F.-Z. M., Glass, J. I., Villa, E., Dame, R. T., & Luthey-Schulten, Z. (2021) · Frontiers in Molecular Biosciences

Genomics and Chromatin DynamicsRNA and protein synthesis mechanisms

Cited by 30

Toward a Whole-Cell model of ribosome biogenesis: kinetic modeling of SSU assembly

Earnest, E. E., Lai, J., Chen, K., Hallock, M. J., Williamson, J. R., & Luthey-Schulten, Z. (2015) · Biophysical Journal

RNA and protein synthesis mechanismsGene Regulatory Network Analysis

Cited by 30

Influence of Montmorillonite on Nucleotide Oligomerization Reactions: A Molecular Dynamics Study

Mathew, D. C., & Luthey-Schulten, Z. (2010) · Origins of Life and Evolution of Biospheres

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 28

Metabolite Damage and Damage-Control in a Minimal Genome

Haas, D., Thamm, A. M., Sun, J., Huang, L., Sun, L., Beaudoin, G. A. W., Wise, K. S., Lerma-Ortiz, C., Bruner, S. D., Breuer, M., et al. (2021) · mBio

Microbial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology

Cited by 24

Integrating cellular and molecular structures and dynamics into whole-cell models

Luthey-Schulten, Z., Thornburg, Z. R., & Gilbert, B. R. (2022) · Current Opinion in Structural Biology

Gene Regulatory Network AnalysisProtein Structure and Dynamics

Cited by 23

Kinetic modeling of the genetic information processes in a minimal cell

Thornburg, Z. R., Melo, M. C. R., Bianchi, D., Brier, T. A., Crotty, C., Breuer, M., Smith, H. O., Hutchison, C. A., Glass, J. I., & Luthey-Schulten, Z. (2019) · Frontiers in Molecular Biosciences

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 22

Toward the Complete Functional Characterization of a Minimal Bacterial Proteome

Bianchi, D. M., Pelletier, J. F., Hutchison, C. A., Glass, J. I., & Luthey-Schulten, Z. (2022) · The Journal of Physical Chemistry B

Microbial Metabolic Engineering and BioproductionProtein Structure and Dynamics

Cited by 22

Population FBA predicts metabolic phenotypes in yeast

Labhsetwar, P., Melo, M. C. R., Cole, J. A., & Luthey-Schulten, Z. (2017) · PLOS Computational Biology

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 21

Dynamics of chromosome organization in a minimal bacterial cell

Gilbert, B. R., Thornburg, Z. R., Brier, T. A., Stevens, J. A., Grünewald, F., Stone, J. E., Marrink, S. J., & Luthey-Schulten, Z. (2023) · Frontiers in Cell and Developmental Biology

Genomics and Chromatin DynamicsBacterial Genetics and Biotechnology

Cited by 19