Cited by 523Protein Structure and DynamicsRNA and protein synthesis mechanismsProtein purification and stability

Toward an outline of the topography of a realistic protein-folding funnel.

Open access
Onuchic, J N, Wolynes, P G, Luthey-Schulten, Z, Socci, N D·1995·Proceedings of the National Academy of Sciences

Abstract

Experimental information on the structure and dynamics of molten globules gives estimates for the energy landscape's characteristics for folding highly helical proteins, when supplemented by a theory of the helix-coil transition in collapsed heteropolymers. A law of corresponding states relating simulations on small lattice models to real proteins possessing many more degrees of freedom results. This correspondence reveals parallels between "minimalist" lattice results and recent experimental results for the degree of native character of the folding transition state and molten globule and also pinpoints the needs of further experiments.

Integrity signals

Registry

Crossref · 10.1073/pnas.92.8.3626

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Onuchic, J. N., Wolynes, P. G., Luthey-Schulten, Z., & Socci, N. D.
Affiliations
University of Illinois Urbana-Champaign (US)
Venue
Proceedings of the National Academy of Sciences
Published
1995-04-11
Volume
92
Issue
8
Pages
3626-3630
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2041721370
Cited by
523
References
30
Citations by year
2026: 6 · 2025: 9 · 2024: 9 · 2022: 10 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 17
FWCI
15.76
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (9316186)
  • Arnold and Mabel Beckman Foundation
  • National Institutes of Health
  • National Institute of General Medical Sciences (1R01 GM44557, R01GM044557)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
Keywords
protein folding, folding funnel, energy landscape, molten globule, helix-coil transition, heteropolymers, lattice model, law of corresponding states, folding transition state, helical proteins
MeSH terms
Computer Simulation, Models, Chemical, Protein Conformation, Protein Folding

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review