Toward an outline of the topography of a realistic protein-folding funnel.
Open accessAbstract
Experimental information on the structure and dynamics of molten globules gives estimates for the energy landscape's characteristics for folding highly helical proteins, when supplemented by a theory of the helix-coil transition in collapsed heteropolymers. A law of corresponding states relating simulations on small lattice models to real proteins possessing many more degrees of freedom results. This correspondence reveals parallels between "minimalist" lattice results and recent experimental results for the degree of native character of the folding transition state and molten globule and also pinpoints the needs of further experiments.
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- Authors
- Onuchic, J. N., Wolynes, P. G., Luthey-Schulten, Z., & Socci, N. D.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1995-04-11
- Volume
- 92
- Issue
- 8
- Pages
- 3626-3630
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC42220
- OpenAlex
- W2041721370
- Cited by
- 523
- References
- 30
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2022: 10 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 17
- FWCI
- 15.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9316186)
- Arnold and Mabel Beckman Foundation
- National Institutes of Health
- National Institute of General Medical Sciences (1R01 GM44557, R01GM044557)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
- Keywords
- protein folding, folding funnel, energy landscape, molten globule, helix-coil transition, heteropolymers, lattice model, law of corresponding states, folding transition state, helical proteins
- MeSH terms
- Computer Simulation, Models, Chemical, Protein Conformation, Protein Folding
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