Giasson, Benoit I.

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2002) · Neuron

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 1,266

A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly

Giasson, B. I., Murray, I. V. J., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 1,080

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

Giasson, B. I., Forman, M. S., Higuchi, M., Golbe, L. I., Graves, C. L., Kotzbauer, P. T., Trojanowski, J. Q., & Lee, V. M.-Y. (2003) · Science

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 879

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., & Lee, V. M. ‐. (1998) · Annals of Neurology

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 686

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 533

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation

Circadian rhythm and melatoninNeuroinflammation and Neurodegeneration Mechanisms

Cited by 524

MAPT mutations, tauopathy, and mechanisms of neurodegeneration

Strang, K. H., Golde, T. E., & Giasson, B. I. (2019) · Laboratory Investigation

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 424

Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration

Yazawa, I., Giasson, B. I., Sasaki, R., Zhang, B., Joyce, S., Uryu, K., Trojanowski, J. Q., & Lee, V. M.-Y. (2005) · Neuron

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 301

Reversible Inhibition of α-Synuclein Fibrillization by Dopaminochrome-mediated Conformational Alterations

Norris, E. H., Giasson, B. I., Hodara, R., Xu, S., Trojanowski, J. Q., Ischiropoulos, H., & Lee, V. M.-Y. (2005) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 273

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

Uchihara, T., & Giasson, B. I. (2016) · Acta Neuropathologica

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 249

Are ubiquitination pathways central to Parkinson’s disease?

Giasson, B. I., & Lee, V. M.-Y. (2003) · Cell

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 234

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

Klegeris, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. (2008) · Neurobiology of Aging

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 227

Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker

Sacino, A. N., Brooks, M., McKinney, A. B., Thomas, M. A., Shaw, G., Golde, T. E., & Giasson, B. I. (2014) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 141

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Sorrentino, Z. A., Brooks, M. M. T., Hudson, V., Rutherford, N. J., Golde, T. E., Giasson, B. I., & Chakrabarty, P. (2017) · Molecular Neurodegeneration

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 79

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy

Koller, E. J., Gonzalez De La Cruz, E., Machula, T., Ibanez, K. R., Lin, W.-L., Williams, T., Riffe, C. J., Ryu, D., Strang, K. H., Liu, X., et al. (2019) · Human Molecular Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 63

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration

Sorrentino, Z. A., Xia, Y., Funk, C., Riffe, C. J., Rutherford, N. J., Ceballos Diaz, C., Sacino, A. N., Price, N. D., Golde, T. E., Giasson, B. I., et al. (2018) · Neurobiology of Disease

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 54

Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation

Koller, E. J., Ibanez, K. R., Vo, Q., McFarland, K. N., Gonzalez De La Cruz, E., Zobel, L., Williams, T., Xu, G., Ryu, D., Patel, P., et al. (2022) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 23

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

Lloyd, G. M., Long, B., Quintin, S., Sorrentino, Z. A., Gorion, K.-M. M., Bell, B. M., Carrillo, D., Sullivan, P., Borchelt, D., & Giasson, B. I. (2023) · Acta Neuropathologica Communications

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 11