Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
Open accessAbstract
Progressive aggregation of alpha-synuclein (αS) through formation of amorphous pale bodies to mature Lewy bodies or in neuronal processes as Lewy neurites may be the consequence of conformational protein changes and accumulations, which structurally represents "molecular template". Focal initiation and subsequent spread along anatomically connected structures embody "structural template". To investigate the hypothesis that both processes might be closely associated and involved in the progression of αS pathology, which can be observed in human brains, αS amyloidogenic precursors termed "seeds" were experimentally injected into the brain or peripheral nervous system of animals. Although these studies showed that αS amyloidogenic seeds can induce αS pathology, which can spread in the nervous system, the findings are still not unequivocal in demonstrating predominant transsynaptic or intraneuronal spreads either in anterograde or retrograde directions. Interpretation of some of these studies is further complicated by other concurrent aberrant processes including neuroimmune activation, injury responses and/or general perturbation of proteostasis. In human brain, αS deposition and neuronal degeneration are accentuated in distal axon/synapse. Hyperbranching of axons is an anatomical commonality of Lewy-prone systems, providing a structural basis for abundance in distal axons and synaptic terminals. This neuroanatomical feature also can contribute to such distal accentuation of vulnerability in neuronal demise and the formation of αS inclusion pathology. Although retrograde progression of αS aggregation in hyperbranching axons may be a consistent feature of Lewy pathology, the regional distribution and gradient of Lewy pathology are not necessarily compatible with a predictable pattern such as upward progression from lower brainstem to cerebral cortex. Furthermore, "focal Lewy body disease" with the specific isolated involvement of autonomic, olfactory or cardiac systems suggests that spread of αS pathology is not always consistent. In many instances, the regional variability of Lewy pathology in human brain cannot be explained by a unified hypothesis such as transsynaptic spread. Thus, the distribution of Lewy pathology in human brain may be better explained by variable combinations of independent focal Lewy pathology to generate "multifocal Lewy body disease" that could be coupled with selective but variable neuroanatomical spread of αS pathology. More flexible models are warranted to take into account the relative propensity to develop Lewy pathology in different Lewy-prone systems, even without interconnections, compatible with the expanding clinicopathological spectra of Lewy-related disorders. These revised models are useful to better understand the mechanisms underlying the variable progression of Lewy body diseases so that diagnostic and therapeutic strategies are improved.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the human brain, synuclein deposition and neuronal degeneration are accentuated in distal regions.
“In the human brain, synuclein deposition and neuronal degeneration are accentuated in distal regions23.”
From Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice (2018) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382 · see citing works
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064 · see citing works
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836 · see citing works
The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737 · see citing works
Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563 · see citing works
α-synuclein locus duplication as a cause of familial Parkinson's disease
Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17103-1 · Cited by 2,029 · see citing works
α-Synuclein is phosphorylated in synucleinopathy lesions
Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M., Shen, J., Takio, K., & Iwatsubo, T. (2002) · Nature Cell Biology · doi:10.1038/ncb748 · Cited by 1,906 · see citing works
Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes
Davidson, W. S., Jonas, A., Clayton, D. F., & George, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9443 · Cited by 1,588 · see citing works
Volpicelli-Daley, L. A., Luk, K. C., Patel, T. P., Tanik, S. A., Riddle, D. M., Stieber, A., Meaney, D. F., Trojanowski, J. Q., & Lee, V. M.-Y. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.033 · Cited by 1,569 · see citing works
Conway, K. A., Lee, S., Rochet, J., Ding, T. T., Williamson, R. E., & Lansbury, P. T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.571 · Cited by 1,543 · see citing works
Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,501 · see citing works
Anderson, J. P., Walker, D., Goldstein, J. M., de Laat, R., Banducci, K., Caccavello, R. J., Barbour, R., Huang, J., Kling, K., Lee, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600933200 · Cited by 1,418 · see citing works
Alpha-synuclein and neurodegenerative diseases
Goedert, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081564 · Cited by 1,402 · see citing works
Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., Rohan de Silva, H. A., Kittel, A., & Saitoh, T. (1995) · Neuron · doi:10.1016/0896-6273(95)90302-x · Cited by 1,316 · see citing works
Modification of Parkinsonism — Chronic Treatment with L-Dopa
Cotzias, G. C., Papavasiliou, P. S., & Gellene, R. A. (1969) · New England Journal of Medicine · doi:10.1056/nejm196902132800701 · Cited by 1,287 · see citing works
Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein
Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00682-7 · Cited by 1,266 · see citing works
Self-citationZhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works
Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.242 · Cited by 1,190 · see citing works
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
Peelaerts, W., Bousset, L., Van der Perren, A., Moskalyuk, A., Pulizzi, R., Giugliano, M., Van den Haute, C., Melki, R., & Baekelandt, V. (2015) · Nature · doi:10.1038/nature14547 · Cited by 1,130 · see citing works
Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115 · see citing works
Evidence for a Partially Folded Intermediate in α-Synuclein Fibril Formation
Uversky, V. N., Li, J., & Fink, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010907200 · Cited by 1,096 · see citing works
Luk, K. C., Kehm, V. M., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M. ‐. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112457 · Cited by 1,087 · see citing works
Identification of two distinct synucleins from human brain
Jakes, R., Spillantini, M. G., & Goedert, M. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00395-5 · Cited by 1,080 · see citing works
Giasson, B. I., Murray, I. V. J., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008919200 · Cited by 1,080 · see citing works
Self-citationEliezer, D., Kutluay, E., Bussell, R., & Browne, G. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4538 · Cited by 1,077 · see citing works
Parkinson's disease: a dual‐hit hypothesis
Hawkes, C. H., Del Tredici, K., & Braak, H. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00874.x · Cited by 1,021 · see citing works
Clinical progression in Parkinson disease and the neurobiology of axons
Cheng, H., Ulane, C. M., & Burke, R. E. (2010) · Annals of Neurology · doi:10.1002/ana.21995 · Cited by 1,012 · cited 3× · see citing works
“Deficiency of dopamine at their axon terminals in caudate/putamen is more profound (30 % of agematched control) [32] than the loss of nigral neurons [85], indicating distally accentuated gradient of degeneration, also confirmed by PET studies in PD patients at the onset of motor deficits.”
BackgroundResultα-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
Chandra, S. S., Gallardo, G., Fernández‐Chacón, R., Schlüter, O. M., & Südhof, T. C. (2005) · Cell · doi:10.1016/j.cell.2005.09.028 · Cited by 967 · see citing works
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
Boeve, B. F., Silber, M. H., Saper, C. B., Ferman, T. J., Dickson, D. W., Parisi, J. E., Benarroch, E. E., Ahlskog, J. E., Smith, G. E., Caselli, R., et al. (2007) · Brain · doi:10.1093/brain/awm056 · Cited by 960 · see citing works
Luk, K. C., Song, C., O’Brien, P., Stieber, A., Branch, J. R., Brunden, K. R., Trojanowski, J. Q., & Lee, V. M. ‐. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908005106 · Cited by 958 · see citing works
Mitochondrial dysfunction and oxidative stress in Parkinson's disease
Subramaniam, S., & Chesselet, M. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.04.004 · Cited by 925 · see citing works
Arizona Parkinson’s Disease Consortium, Beach, T. G., Adler, C. H., Sue, L. I., Vedders, L., Lue, L., White III, C. L., Akiyama, H., Caviness, J. N., Shill, H. A., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0664-3 · Cited by 911 · see citing works
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
Cremades, N., Cohen, S. I. A., Deas, E., Abramov, A. Y., Chen, A. Y., Orte, Á., Sandal, M., Clarke, R. W., Dunne, P., Aprile, F. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.037 · Cited by 901 · see citing works
Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877 · see citing works
Prion-like spreading of pathological α-synuclein in brain
Masuda-Suzukake, M., Nonaka, T., Hosokawa, M., Oikawa, T., Arai, T., Akiyama, H., Mann, D. M. A., & Hasegawa, M. (2013) · Brain · doi:10.1093/brain/awt037 · Cited by 867 · see citing works
Matsuda, W., Furuta, T., Nakamura, K. C., Hioki, H., Fujiyama, F., Arai, R., & Kaneko, T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4029-08.2009 · Cited by 865 · see citing works
Kim, C., Ho, D.-H., Suk, J.-E., You, S., Michael, S., Kang, J., Joong Lee, S., Masliah, E., Hwang, D., Lee, H.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms2534 · Cited by 856 · see citing works
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal‐Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R., & McLean, P. J. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-42 · Cited by 852 · see citing works
George, J. M., Jin, H., Woods, W. S., & Clayton, D. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90040-3 · Cited by 844 · see citing works
Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates
Lee, H.-J., Patel, S. S., & Lee, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0692-05.2005 · Cited by 798 · see citing works
Conway, K. A., Harper, J. D., & Lansbury, P. T. (2000) · Biochemistry · doi:10.1021/bi991447r · Cited by 786 · see citing works
Where Does Parkinson Disease Pathology Begin in the Brain?
Del Tredici, K., Rüb, U., de Vos, R. A. I., Bohl, J. R. E., & Braak, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.5.413 · Cited by 773 · see citing works
Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
Serpell, L. C., Berriman, J. A., Jakes, R., Goedert, M., & Crowther, R. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4897 · Cited by 748 · see citing works
Kirik, D., Rosenblad, C., Bürger, C., Lundberg, C., Johansen, T. E., Muzyczka, N., Mandel, R. J., & Björklund, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02780.2002 · Cited by 730 · see citing works
α-Synuclein Fibrillogenesis Is Nucleation-dependent
Wood, S. J., Wypych, J., Steavenson, S., Louis, J., Citron, M., & Biere, A. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19509 · Cited by 719 · see citing works
Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation
Narhi, L. O., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F. H., Sitney, K. C., Denis, P., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9843 · Cited by 710 · see citing works
Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications
Farrer, M. J., Kachergus, J. M., Forno, L. S., Lincoln, S., Wang, D., Hulihan, M., Maraganore, D. M., Gwinn, K. A., Wszołek, Z. K., Dickson, D. W., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10846 · Cited by 699 · see citing works
G51D α‐synuclein mutation causes a novel Parkinsonian–pyramidal syndrome
Lesage, S., Anheim, M., Letournel, F., Bousset, L., Honoré, A., Rozas, N., Pieri, L., Madiona, K., Dürr, A., Melki, R., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23894 · Cited by 697 · see citing works
Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
Guo, J. L., Covell, D. J., Daniels, J. P., Iba, M., Stieber, A., Zhang, B., Riddle, D. M., Kwong, L. K., Xu, Y., Trojanowski, J. Q., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.057 · Cited by 680 · see citing works
Alpha‐synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
Appel‐Cresswell, S., Vilariño‐Güell, C., Encarnacion, M. J., Sherman, H. E., Yu, I. S., Shah, B., Weir, D. M., Thompson, C., Szu‐Tu, C., Trinh, J., et al. (2013) · Movement Disorders · doi:10.1002/mds.25421 · Cited by 669 · see citing works
THE BIOCHEMISTRY OF PARKINSON'S DISEASE
Cookson, M. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133400 · Cited by 659 · see citing works
Braak, H., Bohl, J. R., Müller, C. M., Rüb, U., de Vos, R. A. I., & Del Tredici, K. (2006) · Movement Disorders · doi:10.1002/mds.21065 · Cited by 630 · see citing works
Recasens, A., Dehay, B., Bové, J., Carballo‐Carbajal, I., Doveró, S., Pérez‐Villalba, A., Fernagut, P., Blesa, J., Parent, A., Perier, C., et al. (2013) · Annals of Neurology · doi:10.1002/ana.24066 · Cited by 629 · see citing works
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies
Codolo, G., Plotegher, N., Pozzobon, T., Brucale, M., Tessari, I., Bubacco, L., & de Bernard, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055375 · Cited by 585 · see citing works
Kramer, M. L., & Schulz-Schaeffer, W. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4564-06.2007 · Cited by 571 · see citing works
Biochemical aspects of Parkinson's disease
Hornykiewicz, O. (1998) · Neurology · doi:10.1212/wnl.51.2_suppl_2.s2 · Cited by 563 · see citing works
Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique
Cedarbaum, J. M., & Aghajanian, G. K. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901780102 · Cited by 549 · see citing works
Pasanen, P., Myllykangas, L., Siitonen, M., Raunio, A., Kaakkola, S., Lyytinen, J., Tienari, P. J., Pöyhönen, M., & Paetau, A. E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.024 · Cited by 535 · see citing works
Bianco, C. L., Ridet, J.-L., Schneider, B. L., Déglon, N., & Aebischer, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152339799 · Cited by 533 · see citing works
Li, J., Uversky, V. N., & Fink, A. L. (2001) · Biochemistry · doi:10.1021/bi010616g · Cited by 513 · see citing works
Giasson, B. I., Uryu, K., Trojanowski, J. Q., & Lee, V. M. ‐. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7619 · Cited by 505 · see citing works
Self-citationBerg, D., Postuma, R. B., Bloem, B. R., Chan, P., Dubois, B., Gasser, T., Goetz, C. G., Halliday, G. M., Hardy, J., Lang, A. E., et al. (2014) · Movement Disorders · doi:10.1002/mds.25844 · Cited by 502 · see citing works
THE BRAIN-STEM LESIONS IN PARKINSONISM
GREENFIELD, J. G., & Bosanquet, F. D. (1953) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.16.4.213 · Cited by 494 · see citing works
Axon degeneration in Parkinson's disease
Burke, R. E., & O’Malley, K. L. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.011 · Cited by 494 · see citing works
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
Hauser, D. N., & Hastings, T. G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.011 · Cited by 470 · see citing works
Assembly-dependent endocytosis and clearance of extracellular a-synuclein
Lee, H.-J., Suk, J.-E., Bae, E.-J., Lee, J.-H., Paik, S. R., & Lee, S.-J. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.01.017 · Cited by 470 · see citing works
A novel α-synuclein missense mutation in Parkinson disease
Proukakis, C., Dudzik, C. G., Brier, T., Mackay, D. S., Cooper, J. A. D., Millhauser, G. L., Houlden, H., & Schapira, A. H. V. (2013) · Neurology · doi:10.1212/wnl.0b013e31828727ba · Cited by 465 · see citing works
Orimo, S., Uchihara, T., Nakamura, A., Mori, F., Kakita, A., Wakabayashi, K., & Takahashi, H. (2007) · Brain · doi:10.1093/brain/awm302 · Cited by 462 · see citing works
Self-citationKiely, A. P., Asi, Y. T., Kara, E., Limousin, P. D., Ling, H., Lewis, P. A., Proukakis, C., Quinn, N. P., Lees, A. J., Hardy, J., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1096-7 · Cited by 450 · see citing works
Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
Jellinger, K. A. (2011) · Movement Disorders · doi:10.1002/mds.23795 · Cited by 448 · see citing works
Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway
Lee, H.-J., Khoshaghideh, F., Patel, S., & Lee, S.-J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3809-03.2004 · Cited by 445 · see citing works
Living on the edge with too many mouths to feed: Why dopamine neurons die
Bolam, J. P., & Pissadaki, E. K. (2012) · Movement Disorders · doi:10.1002/mds.25135 · Cited by 439 · see citing works
Recent Advances in the Genetics of Parkinson's Disease
Martin, I., Dawson, V. L., & Dawson, T. M. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082410-101440 · Cited by 438 · see citing works
Transmission of multiple system atrophy prions to transgenic mice
Watts, J. C., Giles, K., Oehler, A., Middleton, L. T., Dexter, D. T., Gentleman, S., DeArmond, S. J., & Prusiner, S. B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318268110 · Cited by 433 · see citing works
Microscopic analysis of polymerization dynamics with individual actin filaments
Fujiwara, I., Takahashi, S., Tadakuma, H., Funatsu, T., & Ishiwata, S. (2002) · Nature Cell Biology · doi:10.1038/ncb841 · Cited by 420 · see citing works
Westlund, K. N., & Coulter, J. D. (1980) · Brain Research Reviews · doi:10.1016/0165-0173(80)90009-0 · Cited by 414 · see citing works
The progression of pathology in longitudinally followed patients with Parkinson’s disease
Halliday, G. M., Hely, M. A., Reid, W. G. J., & Morris, J. G. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0344-8 · Cited by 410 · see citing works
L-dopa therapy in Parkinson's disease: a critical review of nine years' experience.
Barbeau, A. (1969) · PubMed · Cited by 409 · see citing works
Kirik, D., Annett, L. E., Bürger, C., Muzyczka, N., Mandel, R. J., & Björklund, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536383100 · Cited by 404 · see citing works
Boeve, B. F., Silber, M. H., Ferman, T. J., Lin, S. C., Benarroch, E. E., Schmeichel, A. M., Ahlskog, J. E., Caselli, R. J., Jacobson, S., Sabbagh, M., et al. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2012.10.015 · Cited by 393 · see citing works
Paumier, K. L., Luk, K. C., Manfredsson, F. P., Kanaan, N. M., Lipton, J. W., Collier, T. J., Steece‐Collier, K., Kemp, C. J., Celano, S. L., Schulz, E., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.06.003 · Cited by 386 · see citing works
A critical evaluation of the Braak staging scheme for Parkinson's disease
Burke, R. E., Dauer, W. T., & Vonsattel, J. P. (2008) · Annals of Neurology · doi:10.1002/ana.21541 · Cited by 377 · see citing works
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
Mougenot, A.-L. J., Nicot, S., Bencsik, A. A., Morignat, E., Verchère, J., Lakhdar, L., Legastelois, S., & Baron, T. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.022 · Cited by 375 · see citing works
The E46K Mutation in α-Synuclein Increases Amyloid Fibril Formation
Greenbaum, E. A., Graves, C. L., Mishizen-Eberz, A. J., Lupoli, M. A., Lynch, D. R., Englander, S. W., Axelsen, P. H., & Giasson, B. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411638200 · Cited by 370 · see citing works
Self-citationNeuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transport
Freundt, E. C., Maynard, N., Clancy, E. K., Roy, S., Bousset, L., Sourigues, Y., Covert, M. W., Melki, R., Kirkegaard, K., & Brahic, M. (2012) · Annals of Neurology · doi:10.1002/ana.23747 · Cited by 370 · see citing works
McCann, H., Stevens, C. H., Cartwright, H., & Halliday, G. M. (2014) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(13)70017-8 · Cited by 364 · see citing works
El‐Agnaf, O. M. A., Jakes, R., Curran, M. D., Middleton, D., Ingenito, R., Bianchi, E., Pessi, A., Neill, D., & Wallace, A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01418-5 · Cited by 363 · see citing works
A vector for expressing foreign genes in the brains and hearts of transgenic mice
Borchelt, D., Davis, J. A., Fischer, M., Lee, M. K., Slunt, H. H., Ratovitski, T., Regard, J. B., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., et al. (1996) · Genetic Analysis Biomolecular Engineering · doi:10.1016/s1050-3862(96)00167-2 · Cited by 362 · see citing works
Pathological roles of α-synuclein in neurological disorders
Vekrellis, K., Xilouri, M., Emmanouilidou, E., Rideout, H. J., & Stefanis, L. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70213-7 · Cited by 359 · see citing works
Parkkinen, L., Pirttilä, T., & Alafuzoff, I. I. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0346-6 · Cited by 357 · see citing works
Pissadaki, E. K., & Bolam, J. P. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00013 · Cited by 349 · see citing works
Hilton, D., Stephens, M., Kirk, L., Edwards, P., Potter, R., Zajicek, J., Broughton, E., Hagan, H., & Carroll, C. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1214-6 · Cited by 345 · see citing works
Clearance and deposition of extracellular α-synuclein aggregates in microglia
Lee, H.-J., Suk, J.-E., Bae, E.-J., & Lee, S.-J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.045 · Cited by 343 · see citing works
Properties of native brain α-synuclein
Burré, J., Vivona, S., Diao, J., Sharma, M., Brünger, A. T., & Südhof, T. C. (2013) · Nature · doi:10.1038/nature12125 · Cited by 340 · see citing works
Seeded Aggregation and Toxicity of α-Synuclein and Tau
Nonaka, T., Watanabe, S., Iwatsubo, T., & Hasegawa, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.148460 · Cited by 330 · see citing works
Bloch, A., Probst, A., Bissig, H., Adams, H., & Tolnay, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00727.x · Cited by 330 · see citing works
Sacino, A. N., Brooks, M., Thomas, M. A., McKinney, A. B., Lee, S., Regenhardt, R. W., McGarvey, N. H., Ayers, J. I., Notterpek, L. M., Borchelt, D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321785111 · Cited by 328 · see citing works
Self-citationResearch in motion: the enigma of Parkinson's disease pathology spread
Brundin, P., Li, J., Holton, J. L., Lindvall, O., & Révész, T. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2477 · Cited by 328 · see citing works
Tran, H., Chung, C. H.-Y., Iba, M., Zhang, B., Trojanowski, J. Q., Luk, K. C., & Lee, V. M. ‐. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.033 · Cited by 324 · see citing works
Braak, H., Sastre, M., Böhl, J., de Vos, R. A. I., & Tredici, K. D. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0193-x · Cited by 320 · see citing works
Neuronal vulnerability, pathogenesis, and Parkinson's disease
Sulzer, D. L., & Surmeier, D. J. (2012) · Movement Disorders · doi:10.1002/mds.25095 · Cited by 315 · see citing works
Lipid Binding Inhibits α-Synuclein Fibril Formation
Zhu, M., & Fink, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210136200 · Cited by 314 · see citing works
Okazaki, H., Lipkin, L. E., & Aronson, S. M. (1961) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196104000-00007 · Cited by 303 · see citing works
Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship
Xilouri, M., Brekk, O. R., & Stefanis, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8341-2 · Cited by 299 · see citing works
Neuroanatomy and Pathology of Sporadic Parkinson's Disease
Braak, H., & Tredici, K. D. (2008) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-540-79850-7 · Cited by 297 · see citing works
Mutation E46K increases phospholipid binding and assembly into filaments of human α‐synuclein
Choi, W., Zibaee, S., Jakes, R., Serpell, L. C., Davletov, B. A., Crowther, R. A., & Goedert, M. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.038 · Cited by 286 · see citing works
Tan, T. Z., Miow, Q. H., Huang, R. Y., Wong, M. K., Ye, J., Lau, J. A., Wu, M., Hadi, L. A., Soong, R., Choolani, M. A., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201823 · Cited by 281 · see citing works
Orimo, S., Suzuki, M., Inaba, A., & Mizusawa, H. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.01.009 · Cited by 279 · see citing works
Alpha‐synuclein transfers from neurons to oligodendrocytes
Reyes, J. F., Rey, N. L., Bousset, L., Melki, R., Brundin, P., & Angot, É. (2013) · Glia · doi:10.1002/glia.22611 · Cited by 278 · see citing works
Roberts, R. F., Wade‐Martins, R., & Alegre‐Abarrategui, J. (2015) · Brain · doi:10.1093/brain/awv040 · Cited by 272 · see citing works
Hashimoto, M., Hsu, L. J., Sisk, A., Xia, Y., Takeda, A., Sundsmo, M. P., & Masliah, E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00514-9 · Cited by 267 · see citing works
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
Rey, N. L., Petit, G. H., Bousset, L., Melki, R., & Brundin, P. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1160-3 · Cited by 267 · see citing works
Lewy Bodies of Parkinson's Disease Contain Neurofilament Antigens
Goldman, J. E., Yen, S.-H. C., Chiu, F., & Peress, N. S. (1983) · Science · doi:10.1126/science.6308771 · Cited by 260 · see citing works
Molecular nexopathies: a new paradigm of neurodegenerative disease
Warren, J. D., Rohrer, J. D., Schott, J. M., Fox, N. C., Hardy, J., & Rossor, M. N. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.007 · Cited by 259 · see citing works
Caudo‐rostral brain spreading of α‐synuclein through vagal connections
Ulusoy, A., Rusconi, R., Pérez‐Revuelta, B. I., Musgrove, R. E., Helwig, M., Winzen‐Reichert, B., & Monte, D. A. D. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302475 · Cited by 250 · see citing works
Pathological alpha-synuclein propagates through neural networks
Masuda‐Suzukake, M., Nonaka, T., Hosokawa, M., Kubo, M., Shimozawa, A., Akiyama, H., & Hasegawa, M. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0088-8 · Cited by 249 · see citing works
Molecular mechanisms of α-synuclein neurodegeneration
Waxman, E. A., & Giasson, B. I. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.013 · Cited by 241 · see citing works
Self-citationFares, M.-B., Ait‐Bouziad, N., Dikiy, I., Mbefo, M. K., Jovi, A., Kiely, A. P., Holton, J. L., Lee, S., Gitler, A. D., Eliezer, D., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu165 · Cited by 241 · see citing works
Cutaneous neuropathy in Parkinson’s disease: a window into brain pathology
Doppler, K., Ebert, S., Üçeyler, N., Trenkwalder, C., Ebentheuer, J., Volkmann, J., & Sommer, C. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1284-0 · Cited by 239 · see citing works
Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?
Tomé, C. M. L., Tyson, T., Rey, N. L., Grathwohl, S. A., Britschgi, M., & Brundin, P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8267-8 · Cited by 237 · see citing works
Tredici, K. D., & Braak, H. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301817 · Cited by 237 · see citing works
Lewy bodies in cerebral cortex. Report of three cases
Kosaka, K. (1978) · Acta Neuropathologica · doi:10.1007/bf00690978 · Cited by 235 · see citing works
Are ubiquitination pathways central to Parkinson’s disease?
Giasson, B. I., & Lee, V. M.-Y. (2003) · Cell · doi:10.1016/s0092-8674(03)00509-9 · Cited by 234 · see citing works
Self-citationSpecificity and Regulation of Casein Kinase-Mediated Phosphorylation of ??-Synuclein
Waxman, E. A., & Giasson, B. I. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3186fc995 · Cited by 232 · see citing works
Self-citationA Precipitating Role for Truncated α-Synuclein and the Proteasome in α-Synuclein Aggregation
Liu, C.-W., Giasson, B., Lewis, K. A., Lee, V., DeMartino, G., & Thomas, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501508200 · Cited by 224 · see citing works
Self-citationHague, K., Lento, P., Morgello, S., Caro, S., & Kaufmann, H. (1997) · Acta Neuropathologica · doi:10.1007/s004010050693 · Cited by 209 · see citing works
Dopaminergic Cell Loss Induced by Human A30P α -Synuclein Gene Transfer to the Rat Substantia Nigra
Klein, R. L., King, M. A., Hamby, M. E., & Meyer, E. M. (2002) · Human Gene Therapy · doi:10.1089/10430340252837206 · Cited by 209 · see citing works
Irizarry, M. C., Kim, T., McNamara, M. J., Tanzi, R. E., George, J. M., Clayton, D. F., & Hyman, B. T. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199608000-00004 · Cited by 205 · see citing works
Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein
Sung, J. Y., Kim, J., Paik, S. R., Park, J. H., Ahn, Y. S., & Chung, K. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101318200 · Cited by 200 · see citing works
Absence of α-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia
Miller, D. W., Johnson, J. M., Solano, S. M., Hollingsworth, Z. R., Standaert, D. G., & Young, A. B. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0378-1 · Cited by 198 · see citing works
Silver diagnosis in neuropathology: principles, practice and revised interpretation
Uchihara, T. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0200-2 · Cited by 197 · see citing works
Self-citationRegional Multiple Pathology Scores Are Associated with Cognitive Decline in L ewy Body Dementias
Howlett, D. R., Whitfield, D., Johnson, M. A., Attems, J., O'Brien, J. T., Aarsland, D., Lai, M. K. P., Lee, J. H., Chen, C., Ballard, C. G., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12182 · Cited by 196 · see citing works
The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro
Ghosh, D., Mondal, M., Mohite, G. M., Singh, P. K., Ranjan, P., Arunagiri, A., Ghosh, S., Jha, N. N., Kumar, A., & Maji, S. K. (2013) · Biochemistry · doi:10.1021/bi400999d · Cited by 190 · see citing works
Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience
Kovacs, G. G., Alafuzoff, I., Al-Sarraj, S., Arzberger, T., Bogdanovic, N., Capellari, S., Ferrer, I., Gelpi, E., Kövari, V., Kretzschmar, H., et al. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000161560 · Cited by 186 · see citing works
Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss
Annerino, D. M., Arshad, S., Taylor, G. M., Adler, C., Beach, T., & Greene, J. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1040-2 · Cited by 185 · see citing works
Lewy pathology and neurodegeneration in premotor Parkinson's disease
Tredici, K. D., & Braak, H. (2012) · Movement Disorders · doi:10.1002/mds.24921 · Cited by 184 · see citing works
Do α-synuclein aggregates in autonomic plexuses predate Lewy body disorders?
Mínguez‐Castellanos, A., Chamorro, C. E., Sevilla, F. E., Ortega-Moreno, A., Rebollo, A. C., Gómez-Río, M., Concha, A., & Muñoz, D. G. (2007) · Neurology · doi:10.1212/01.wnl.0000264429.59379.d9 · Cited by 183 · see citing works
Evaluation of α-synuclein immunohistochemical methods used by invited experts
Beach, T. G., White, C. L., Hamilton, R. L., Duda, J. E., Iwatsubo, T., Dickson, D. W., Leverenz, J. B., Roncaroli, F., Buttini, M., Hladik, C. L., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0409-8 · Cited by 182 · see citing works
The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity
Khalaf, O., Fauvet, B., Oueslati, A., Dikiy, I., Mahul‐Mellier, A., Ruggeri, F. S., Mbefo, M. K., Vercruysse, F., Dietler, G., Lee, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.553297 · Cited by 180 · see citing works
Kovács, G. G., Wagner, U., Dumont, B., Pikkarainen, M., Osman, A. A., Streichenberger, N., Leisser, I., Verchère, J., Baron, T., Alafuzoff, I. I., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0964-x · Cited by 170 · see citing works
Snaring the Function of α-Synuclein
Bonini, N. M., & Giasson, B. I. (2005) · Cell · doi:10.1016/j.cell.2005.10.017 · Cited by 162 · see citing works
Self-citationGhosh, D., Sahay, S., Ranjan, P., Salot, S., Mohite, G. M., Singh, P. K., Dwivedi, S., Carvalho, E. J., Banerjee, R., Kumar, A., et al. (2014) · Biochemistry · doi:10.1021/bi5010365 · Cited by 158 · see citing works
Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities
Berg, D., Lang, A. E., Postuma, R. B., Maetzler, W., Deuschl, G., Gasser, T., Siderowf, A. D., Schapira, A. H. V., Oertel, W. H., Obeso, J. A., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70047-4 · Cited by 158 · see citing works
Wakabayashi, K., Mori, F., Tanji, K., Orimo, S., & Takahashi, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0706-x · Cited by 156 · see citing works
Advances in Anatomy Embryology and Cell Biology
(2007) · Springer eBooks · doi:10.1007/978-3-540-32948-0_1 · Cited by 153 · see citing works
Sacino, A. N., Brooks, M., McKinney, A. B., Thomas, M. A., Shaw, G., Golde, T. E., & Giasson, B. I. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2102-14.2014 · Cited by 141 · see citing works
Self-citationA Mitocentric View of Parkinson's Disease
Haelterman, N. A. T., Yoon, W. H., Sandoval, H., Jaiswal, M., Shulman, J. M., & Bellen, H. J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014317 · Cited by 138 · see citing works
Rab11a and HSP90 Regulate Recycling of Extracellular α-Synuclein
Liu, J., Zhang, J., Shi, M. Y., Quinn, T. J., Bradner, J. M., Beyer, R., Chen, S., & Zhang, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6202-08.2009 · Cited by 133 · see citing works
Emmer, K. L., Waxman, E. A., Covy, J. P., & Giasson, B. I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.247965 · Cited by 133 · see citing works
Self-citationDivergent effects of the H50Q and G51D SNCA mutations on the aggregation of α‐synuclein
Rutherford, N. J., Moore, B. D., Golde, T. E., & Giasson, B. I. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12806 · Cited by 131 · see citing works
Self-citationGreffard, S., Verny, M., Bonnet, A.-M., Seilhean, D., Hauw, J., & Duyckaerts, C. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.015 · Cited by 130 · see citing works
Essential Tremor Associated With Focal Nonnigral Lewy Bodies
Louis, E. D., Honig, L. S., Vonsattel, J. P., Maraganore, D. M., Borden, S., & Moskowitz, C. B. (2005) · Archives of Neurology · doi:10.1001/archneur.62.6.1004 · Cited by 127 · see citing works
Amino acid sequence motifs and mechanistic features of the membrane translocation of α‐synuclein
Ahn, K. J., Paik, S. R., Chung, K. C., & Kim, J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03731.x · Cited by 123 · see citing works
A new dopaminergic nigro-olfactory projection
Höglinger, G. U., Alvarez‐Fischer, D., Arias-Carrión, Ó., Djufri, M., Windolph, A., Keber, U., Borta, A., Ries, V., Schwarting, R. K. W., Scheller, D., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1451-y · Cited by 122 · see citing works
Thinking laterally about neurodegenerative proteinopathies
Golde, T. E., Borchelt, D., Giasson, B. I., & Lewis, J. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66029 · Cited by 121 · see citing works
Self-citationAxonal degeneration as a therapeutic target in the CNS
Lingor, P., Koch, J. C., Tönges, L., & Bähr, M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1362-3 · Cited by 119 · see citing works
Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice
Sacino, A. N., Brooks, M., Thomas, M. A., McKinney, A. B., McGarvey, N. H., Rutherford, N. J., Ceballos‐Diaz, C., Robertson, J., Golde, T. E., & Giasson, B. I. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1268-0 · Cited by 115 · see citing works
Self-citationDugger, B. N., Boeve, B. F., Murray, M. E., Parisi, J. E., Fujishiro, H., Dickson, D. W., & Ferman, T. J. (2011) · Movement Disorders · doi:10.1002/mds.24003 · Cited by 110 · see citing works
Blesa, J., Pifl, C., Sánchez-González, M. Á., Carlos Juri, C., García‐Cabezas, M. Á., Adánez, R., Iglesias, E., Collantes, M., Peñuelas, I., Sánchez-Hernández, J. J., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.018 · Cited by 107 · see citing works
Wang, J., Xu, G. M., Slunt, H. H., Gonzales, V., Coonfield, M. L., Fromholt, D., Copeland, N. G., Jenkins, N. A., & Borchelt, D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.06.005 · Cited by 106 · see citing works
Characterization of Hydrophobic Residue Requirements for α-Synuclein Fibrillization
Waxman, E. A., Mazzulli, J. R., & Giasson, B. I. (2009) · Biochemistry · doi:10.1021/bi900539p · Cited by 106 · see citing works
Self-citationImmunological features of α‐synuclein in Parkinson's disease
Roodveldt, C., Christodoulou, J. C., & Dobson, C. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00450.x · Cited by 95 · see citing works
Assessment of α-Synuclein Pathology: A Study of the BrainNet Europe Consortium
Alafuzoff, I., Parkkinen, L., Al-Sarraj, S., Arzberger, T., Bell, J., Bodi, I., Bogdanovic, N., Budka, H., Ferrer, I., Gelpi, E., et al. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181633526 · Cited by 90 · see citing works
The black stuff and Konstantin Nikolaevich Tretiakoff
Lees, A. J., Selikhova, M. V., de Andrade, L. A. F., & Duyckaerts, C. J. (2008) · Movement Disorders · doi:10.1002/mds.21855 · Cited by 88 · see citing works
Ebrahimi‐Fakhari, D., Saidi, L.-J., & Wahlster, L. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-79 · Cited by 86 · see citing works
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
Sacino, A. N., Brooks, M., McGarvey, N. H., McKinney, A. B., Thomas, M. A., Levites, Y., Ran, Y., Golde, T. E., & Giasson, B. I. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-38 · Cited by 86 · see citing works
Self-citationWaxman, E. A., & Giasson, B. I. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06592.x · Cited by 82 · see citing works
Self-citationCharacterization of antibodies that selectively detect α-synuclein in pathological inclusions
Waxman, E. A., Duda, J. E., & Giasson, B. I. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0375-1 · Cited by 79 · see citing works
Self-citationTakahashi, M., Ikemura, M., Oka, T., Uchihara, T., Wakabayashi, K., Kakita, A., Takahashi, H., Yoshida, M., Toru, S., Kobayashi, T., et al. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-310686 · Cited by 74 · see citing works
Self-citationLees, A. J. (2009) · Neurology · doi:10.1212/wnl.0b013e318198daec · Cited by 71 · see citing works
Bétemps, D., Verchère, J., Brot, S., Morignat, E., Bousset, L., Gaillard, D., Lakhdar, L., Melki, R., & Baron, T. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-29 · Cited by 71 · see citing works
Úbeda‐Bañón, I., Saiz‐Sánchez, D., de la Rosa‐Prieto, C., & Martı́nez-Marcos, A. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0651-2 · Cited by 69 · see citing works
Controversies over the staging of α-synuclein pathology in Parkinson’s disease
Kalaitzakis, M. E., Graeber, M. B., Gentleman, S. M., & Pearce, R. K. B. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0381-3 · Cited by 68 · see citing works
Pikkarainen, M., MARTIKAINEN, P. M., & Alafuzoff, I. I. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181c6c13d · Cited by 68 · see citing works
Kanazawa, T., Uchihara, T., Takahashi, A., Nakamura, A., Orimo, S., & Mizusawa, H. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00140.x · Cited by 67 · see citing works
Self-citationIncidental Lewy body disease restricted to the heart and stellate ganglia
Miki, Y., Mori, F., Wakabayashi, K., Kuroda, N., & Orimo, S. (2009) · Movement Disorders · doi:10.1002/mds.22775 · Cited by 67 · see citing works
Conformational templating of α-synuclein aggregates in neuronal-glial cultures
Sacino, A. N., Thomas, M. A., Ceballos‐Diaz, C., Cruz, P. E., Rosario, A. M., Lewis, J. M., Giasson, B. I., & Golde, T. E. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-17 · Cited by 66 · see citing works
Self-citationManzoni, C., & Lewis, P. A. (2013) · The FASEB Journal · doi:10.1096/fj.12-223842 · Cited by 62 · see citing works
The human brain : in photographs and diagrams
Nolte, J., & Angevine, J. B. (2013) · Cited by 62 · see citing works
Ebrahimi-Fakhari, D., McLean, P. J., & Unni, V. K. (2012) · Autophagy · doi:10.4161/auto.8.2.18938 · Cited by 61 · see citing works
Cerebral type of Lewy body disease
Kosaka, K., Iseki, E., Odawara, T., & Yamamoto, T. (1996) · Neuropathology · doi:10.1111/j.1440-1789.1996.tb00152.x · Cited by 61 · see citing works
Beaulieu, J., Križ, J., & Julien, J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02830-5 · Cited by 57 · see citing works
Pale Neurites, Premature α‐Synuclein Aggregates with Centripetal Extension from Axon Collaterals
Kanazawa, T., Adachi, E., Orimo, S., Nakamura, A., Mizusawa, H., & Uchihara, T. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00509.x · Cited by 56 · see citing works
Self-citationThe Human Brain: in photographs and diagrams
Allen, C. H. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.59.3.345 · Cited by 55 · see citing works
Giasson, B. I., Duda, J. E., Forman, M. S., Lee, V. M. ‐., & Trojanowski, J. Q. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7805 · Cited by 52 · see citing works
Self-citationA Novel Mechanism of Interaction between α-Synuclein and Biological Membranes
Kim, Y. S., Laurine, E., Woods, W. S., & Lee, S. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.05.004 · Cited by 52 · see citing works
Die Katechinamine im Zentralnervensystem
Sano, I., Taniguchi, K., Gamo, T., Takesada, M., & Kakimoto, Y. (1960) · Journal of Molecular Medicine · doi:10.1007/bf01483607 · Cited by 51 · see citing works
α-Synuclein phosphorylation as a therapeutic target in Parkinson’s disease
Braithwaite, S. P., Stock, J. B., & Mouradian, M. M. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2011-0067 · Cited by 50 · see citing works
Bellucci, A., Navarria, L., Zaltieri, M., Missale, C., & Spano, P. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.031 · Cited by 48 · see citing works
Lesuisse, C. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.22.2525 · Cited by 45 · see citing works
Schweighauser, M., Bacioglu, M., Fritschi, S. K., Shimshek, D. R., Kahle, P. J., Eisele, Y. S., & Jucker, M. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1360-5 · Cited by 40 · see citing works
Rutherford, N. J., & Giasson, B. I. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.04.022 · Cited by 38 · see citing works
Self-citationNo Direct Projection is Observed from the Substantia Nigra to the Dorsal Vagus Complex in the Rat
Wang, Z., Lian, H., Cai, Q.-Q., Song, H., Zhang, X., Zhou, L., Zhang, Y.-M., Zheng, L., & Zhu, J.-X. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130279 · Cited by 32 · see citing works
Yokota, O., Tsuchiya, K., Uchihara, T., Ujike, H., Terada, S., Takahashi, M., Kimura, Y., Ishizu, H., Akiyama, H., & Kuroda, S. (2007) · Neuropathology · doi:10.1111/j.1440-1789.2006.00736.x · Cited by 26 · see citing works
Self-citationParkinson's disease: Acquired frailty of archaic neural networks?
Diederich, N. J., & Parent, A. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.10.003 · Cited by 24 · see citing works
Genetic aspects of Parkinson's disease
Mizuno, Y., Hattori, N., & Mochizuki, H. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)83009-0 · Cited by 3 · see citing works
The Dynamics of α-Synuclein at the Nerve Terminal
Fortin, D. L., Nemani, V. M., & Edwards, R. H. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374028-1.00018-x · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 203 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [57]Fortin DL Nemani VM Edwards RH Naas R Przedborski S A-synuclein, CSPa, SNAREs and neuroprotection in vivo Parkinson’s disease: molecular and therapeutic insights from model systems 2008 1 Waltham Academic Press 237 246
Cited by
Sorted by citations
Selective neuronal vulnerability in Parkinson disease
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.178 · Cited by 1,120 · see citing works
Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study
Horsager, J., Andersen, K. B., Knudsen, K., Skjærbæk, C., Fedorova, T. D., Okkels, N., Schaeffer, E., Bonkat, S. K., Geday, J., Otto, M., et al. (2020) · Brain · doi:10.1093/brain/awaa238 · Cited by 782 · see citing works
Bedarf, J. R., Hildebrand, F., Coelho, L. P., Sunagawa, S., Bahram, M., Goeser, F., Bork, P., & Wüllner, U. (2017) · Genome Medicine · doi:10.1186/s13073-017-0428-y · Cited by 642 · see citing works
Determinants of dopaminergic neuron loss in Parkinson's disease
Surmeier, D. J. (2018) · FEBS Journal · doi:10.1111/febs.14607 · Cited by 455 · see citing works
Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis
Borghammer, P., & Van Den Berge, N. (2019) · Journal of Parkinson’s Disease · doi:10.3233/jpd-191721 · Cited by 419 · see citing works
Review: Sporadic Parkinson's disease: development and distribution ofα‐synuclein pathology
Tredici, K. D., & Braak, H. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12298 · Cited by 396 · see citing works
Uemura, N., Yagi, H., Uemura, M. T., Hatanaka, Y., Yamakado, H., & Takahashi, R. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0257-5 · Cited by 328 · see citing works
Kovács, G. G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020189 · Cited by 321 · see citing works
Knudsen, K., Fedorova, T. D., Hansen, A. K., Sommerauer, M., Otto, M., Svendsen, K. B., Nahimi, A., Stokholm, M. G., Pavese, N., Beier, C. P., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30162-5 · Cited by 309 · see citing works
Kaufman, S. K., Del Tredici, K., Thomas, T. L., Braak, H., & Diamond, M. I. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1855-6 · Cited by 259 · see citing works
Borghammer, P. (2021) · Journal of Parkinson's Disease · doi:10.3233/jpd-202481 · Cited by 259 · see citing works
Molecular biomarkers of Alzheimer's disease: progress and prospects
Lashley, T., Schott, J. M., Weston, P. S. J., Murray, C. E., Wellington, H., Keshavan, A., Foti, S. C., Foiani, M. S., Toombs, J., Rohrer, J. D., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031781 · Cited by 233 · see citing works
Neuropathological evidence of body-first vs. brain-first Lewy body disease
Borghammer, P., Horsager, J., Andersen, K. B., Berge, N. V. D., Raunio, A., Murayama, S., Parkkinen, L., & Myllykangas, L. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105557 · Cited by 218 · see citing works
Parkinson's Disease Is Not Simply a Prion Disorder
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1787-16.2017 · Cited by 186 · see citing works
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
Colin, M., Dujardin, S., Schraen-Maschke, S., Meno-Tetang, G., Duyckaerts, C., Courade, J.-P., & Buée, L. (2020) · Acta Neuropathologica · doi:10.1007/s00401-019-02087-9 · Cited by 187 · see citing works
Sorrentino, Z. A., Giasson, B. I., & Chakrabarty, P. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01977-2 · Cited by 181 · see citing works
Self-citationBrain-to-stomach transfer of α-synuclein via vagal preganglionic projections
Ulusoy, A., Phillips, R. J., Helwig, M., Klinkenberg, M., Powley, T. L., & Di Monte, D. A. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1661-y · Cited by 179 · see citing works
The emerging role of α-synuclein truncation in aggregation and disease
Sorrentino, Z. A., & Giasson, B. I. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011743 · Cited by 173 · see citing works
Self-citationA Cortical Pathogenic Theory of Parkinson’s Disease
Foffani, G., & Obeso, J. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.028 · Cited by 161 · see citing works
Magalhães, P., & Lashuel, H. A. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00357-0 · Cited by 157 · see citing works
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network
Gribaudo, S., Tixador, P., Bousset, L., Fenyi, A., Lino, P., Melki, R., Peyrin, J., & Perrier, A. L. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.007 · Cited by 152 · see citing works
Blood–brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy
Lau, K., Kotzur, R., & Richter, F. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00430-z · Cited by 165 · see citing works
How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology
Borghammer, P. (2017) · Movement Disorders · doi:10.1002/mds.27138 · Cited by 136 · see citing works
Adamowicz, D. H., Roy, S., Salmon, D. P., Galasko, D. R., Hansen, L. A., Masliah, E., & Gage, F. H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3047-16.2016 · Cited by 126 · see citing works
Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice
Sato, S., Uchihara, T., Fukuda, T., Noda, S., Kondo, H., Saiki, S., Komatsu, M., Uchiyama, Y., Tanaka, K., & Hattori, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-21325-w · Cited by 125 · see citing works
Self-citationThe Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses
Jan, A., Gonçalves, N. P., Vægter, C. B., Jensen, P. H., & Ferreira, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158338 · Cited by 126 · see citing works
α-Synuclein in Parkinson’s disease: causal or bystander?
Riederer, P. F., Berg, D., Casadei, N., Cheng, F., Claßen, J., Dresel, C., Jost, W. H., Krüger, R., Müller, T. H., Reichmann, H., et al. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02025-9 · Cited by 118 · see citing works
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats
Berge, N. V. D., Ferreira, N., Mikkelsen, T. W., Alstrup, A. K. O., Tamgüney, G., Karlsson, P., Terkelsen, A. J., Nyengaard, J. R., Jensen, P. H., & Borghammer, P. (2021) · Brain · doi:10.1093/brain/awab061 · Cited by 121 · see citing works
Dura mater is a potential source of Aβ seeds
Kovács, G. G., Lutz, M. I., Ricken, G., Ströbel, T., Höftberger, R., Preusser, M., Regelsberger, G., Hönigschnabl, S., Reiner, A., Fischer, P. A., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1565-x · Cited by 110 · see citing works
Current Treatments and New, Tentative Therapies for Parkinson’s Disease
Pardo-Moreno, T., García‐Morales, V., Suleiman‐Martos, N., Rivas-Domínguez, A., Mohamed-Mohamed, H., Ramos‐Rodríguez, J. J., Melguizo‐Rodríguez, L., & González‐Acedo, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030770 · Cited by 109 · see citing works
Diagnostic Criteria for Dementia with Lewy Bodies: Updates and Future Directions
Yamada, M., Komatsu, J., Nakamura, K., Sakai, K., Samuraki-Yokohama, M., Nakajima, K., & Yoshita, M. (2019) · Journal of Movement Disorders · doi:10.14802/jmd.19052 · Cited by 110 · see citing works
Mezias, C., Rey, N. L., Brundin, P., & Raj, A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104623 · Cited by 106 · see citing works
The brain-first vs. body-first model of Parkinson’s disease with comparison to alternative models
Borghammer, P. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02633-6 · Cited by 104 · see citing works
TIA1 regulates the generation and response to toxic tau oligomers
Jiang, L., Ash, P. E. A., Maziuk, B. F., Ballance, H. I., Boudeau, S., Abdullatif, A. A., Orlando, M., Petrucelli, L., Ikezu, T., & Wolozin, B. L. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1937-5 · Cited by 99 · see citing works
The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System
Joppe, K., Roser, A., Maass, F., & Lingor, P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00015 · Cited by 102 · see citing works
The 3D structure of lipidic fibrils of α-synuclein
Frieg, B., Antonschmidt, L., Dienemann, C., Geraets, J. A., Najbauer, E. E., Matthes, D., de Groot, B. L., Andreas, L. B., Becker, S., Griesinger, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34552-7 · Cited by 101 · see citing works
Ayers, J. I., Brooks, M., Rutherford, N. J., Howard, J. K., Sorrentino, Z. A., Riffe, C. J., & Giasson, B. I. (2016) · Journal of Virology · doi:10.1128/jvi.02095-16 · Cited by 94 · see citing works
Self-citationCalcium, mitochondrial dysfunction and slowing the progression of Parkinson's disease
Surmeier, D. J., Halliday, G. M., & Simuni, T. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.001 · Cited by 99 · see citing works
Sorrentino, Z. A., Vijayaraghavan, N., Gorion, K.-M. M., Riffe, C. J., Strang, K. H., Caldwell, J. D., & Giasson, B. I. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005603 · Cited by 94 · see citing works
Self-citationFrom Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer’s Disease
Zetterberg, H., & Blennow, K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179926 · Cited by 94 · see citing works
Sorrentino, Z. A., Goodwin, M. S., Riffe, C. J., Dhillon, J.-K. S., Xia, Y., Gorion, K.-M. M., Vijayaraghavan, N., McFarland, K. N., Golbe, L. I., Yachnis, A. T., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0787-2 · Cited by 84 · see citing works
Self-citationThe Potential Role of Gut-Derived Inflammation in Multiple System Atrophy
Engen, P. A., Dodiya, H. B., Naqib, A. D., Forsyth, C. B., Green, S. J., Voigt, R. M., Kordower, J. H., Mutlu, E., Shannon, K. M., & Keshavarzian, A. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-160991 · Cited by 84 · see citing works
Sorrentino, Z. A., Brooks, M. M. T., Hudson, V., Rutherford, N. J., Golde, T. E., Giasson, B. I., & Chakrabarty, P. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0182-z · Cited by 79 · see citing works
Self-citationDesigner protein disaggregases to counter neurodegenerative disease
Shorter, J. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.01.008 · Cited by 72 · see citing works
Proteolysis of α‐synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology
Sacino, A. N., Brooks, M., Chakrabarty, P., Saha, K., Khoshbouei, H., Golde, T. E., & Giasson, B. I. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13743 · Cited by 67 · see citing works
Self-citationSchaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01026-0 · Cited by 62 · see citing works
Henrich, M. T., Geibl, F. F., Lee, B., Chiu, W., Koprich, J. B., Brotchie, J. M., Timmermann, L., Decher, N., Matschke, L. A., & Oertel, W. H. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0541-1 · Cited by 65 · see citing works
Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L. M., Negri, G. L., Schwamborn, J. C., Jensen, P. H., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0554-9 · Cited by 66 · see citing works
Carbonell, F., Iturria‐Medina, Y., & Evans, A. C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00037 · Cited by 63 · see citing works
Chartier, S., & Duyckaerts, C. J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2854-6 · Cited by 63 · see citing works
Lashuel, H. A., Mahul‐Mellier, A., Novello, S., Hegde, R. N., Jasiqi, Y., Altay, M. F., Donzelli, S., DeGuire, S. M., Burai, R., Magalhães, P., et al. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00388-7 · Cited by 61 · see citing works
Applying fluid biomarkers to Alzheimer's disease
Zetterberg, H. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00007.2017 · Cited by 62 · see citing works
Cervical skin denervation associates with alpha‐synuclein aggregates in Parkinson disease
Melli, G., Vacchi, E., Biemmi, V., Galati, S., Staedler, C., Ambrosini, R., & Kaelin‐Lang, A. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.669 · Cited by 61 · see citing works
Metagenomics of the Gut Microbiome in Parkinson's Disease: Prodromal Changes
Palacios, N., Wilkinson, J., Bjornevik, K., Schwarzschild, M. A., McIver, L., Ascherio, A., & Huttenhower, C. (2023) · Annals of Neurology · doi:10.1002/ana.26719 · Cited by 59 · see citing works
Rutherford, N. J., Brooks, M., & Giasson, B. I. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0357-9 · Cited by 55 · see citing works
Self-citationA novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
Dhillon, J.-K. S., Riffe, C. J., Moore, B. D., Ran, Y., Chakrabarty, P., Golde, T. E., & Giasson, B. I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184731 · Cited by 56 · see citing works
Self-citationPathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
Guan, Y., Zhao, X., Liu, F., Yan, S., Wang, Y., Du, C., Cui, X., Li, R., & Zhang, C. X. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00159 · Cited by 54 · see citing works
Uchihara, T. (2016) · Neuropathology · doi:10.1111/neup.12348 · Cited by 55 · see citing works
Self-citationUchihara, T., Giasson, B. I., & Paulus, W. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1517-x · Cited by 55 · see citing works
Self-citationKoller, E. J., Brooks, M., Golde, T. E., Giasson, B. I., & Chakrabarty, P. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0142-z · Cited by 54 · see citing works
Self-citationMotor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration
Sorrentino, Z. A., Xia, Y., Funk, C., Riffe, C. J., Rutherford, N. J., Ceballos Diaz, C., Sacino, A. N., Price, N. D., Golde, T. E., Giasson, B. I., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.005 · Cited by 54 · see citing works
Self-citationMicrobes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease
Perez‐Pardo, P., Hartog, M., Garssen, J., & Kraneveld, A. D. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0129-2 · Cited by 52 · see citing works
Vacchi, E., Kaelin‐Lang, A., & Melli, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145030 · Cited by 50 · see citing works
Gastrointestinal disorders in Parkinson’s disease and other Lewy body diseases
Hirayama, M., Nishiwaki, H., Hamaguchi, T., & Ohno, K. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00511-2 · Cited by 51 · see citing works
Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes
Okkels, N., Grothe, M. J., Taylor, J., Hasselbalch, S. G., Fedorova, T. D., Knudsen, K., van der Zee, S., van Laar, T., Bohnen, N. I., Borghammer, P., et al. (2024) · Brain · doi:10.1093/brain/awae069 · Cited by 52 · see citing works
Parkinson's disease: Is it a consequence of human brain evolution?
Diederich, N. J., Surmeier, D. J., Uchihara, T., Grillner, S. E., & Goetz, C. G. (2019) · Movement Disorders · doi:10.1002/mds.27628 · Cited by 49 · see citing works
Self-citationNeuropathology of Nonmotor Symptoms of Parkinson's Disease
Jellinger, K. A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.005 · Cited by 47 · see citing works
Vascellari, S., Melis, M., Palmas, V., Pisanu, S., Serra, A., Perra, D., Santoru, M. L., Oppo, V., Cusano, R., Uva, P., et al. (2021) · Biomolecules · doi:10.3390/biom11020144 · Cited by 48 · see citing works
Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation
Chavarría, C., Ivagnes, R., & Souza, J. M. (2022) · Biomolecules · doi:10.3390/biom12050655 · Cited by 47 · see citing works
Chib, S., & Singh, S. (2022) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2022.107124 · Cited by 47 · see citing works
Dhillon, J.-K. S., Trejo‐Lopez, J. A., Riffe, C. J., Levites, Y., Sacino, A. N., Borchelt, D., Yachnis, A. T., & Giasson, B. I. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0733-3 · Cited by 43 · see citing works
Self-citationDagra, A., Miller, D. R., Lin, M., Gopinath, A., Shaerzadeh, F., Harris, S., Sorrentino, Z. A., Støier, J. F., Velasco, S., Azar, J., et al. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00210-w · Cited by 47 · see citing works
Self-citationAyers, J. I., Riffe, C. J., Sorrentino, Z. A., Diamond, J., Fagerli, E., Brooks, M., Galaleldeen, A., Hart, P. J., & Giasson, B. I. (2018) · Journal of Virology · doi:10.1128/jvi.00586-18 · Cited by 40 · see citing works
Self-citationA new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease
Fevga, C., Park, Y., Lohmann, E., Kievit, A. J. A., Breedveld, G. J., Ferraro, F., de Boer, L., van Minkelen, R., Hanagasi, H. A., Boon, A. J. W., et al. (2021) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2021.06.023 · Cited by 39 · see citing works
Weil, R. S., Lashley, T., Brás, J., Schrag, A. E., & Schott, J. M. (2017) · F1000Research · doi:10.12688/f1000research.11725.1 · Cited by 41 · see citing works
Focused ultrasound in Parkinson's disease: A twofold path toward disease modification
Foffani, G., Trigo-Damas, I., Pineda-Pardo, J., Blesa, J., Rodríguez-Rojas, R., Martínez-Fernández, R., & Obeso, J. (2019) · Movement Disorders · doi:10.1002/mds.27805 · Cited by 36 · see citing works
Motor Progression and Nigrostriatal Neurodegeneration in Parkinson Disease
Furukawa, K., Shima, A., Kambe, D., Nishida, A., Wada, I., Sakamaki‐Tsukita, H., Yoshimura, K., Terada, Y., Sakato, Y., Mitsuhashi, M., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26373 · Cited by 41 · see citing works
Impact of aging on animal models of Parkinson's disease
Klæstrup, I. H., Just, M. K., Holm, K. L., Alstrup, A. K. O., Romero‐Ramos, M., Borghammer, P., & Berge, N. V. D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.909273 · Cited by 42 · see citing works
The Evolution-Driven Signature of Parkinson’s Disease
Diederich, N. J., Uchihara, T., Grillner, S. E., & Goetz, C. G. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.05.001 · Cited by 40 · see citing works
Self-citationModeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice
Aniszewska, A., Bergström, J. J. E., Ingelsson, M., & Ekmark‐Lewén, S. (2022) · Brain and Behavior · doi:10.1002/brb3.2628 · Cited by 37 · see citing works
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course
Tayebi, N., Parisiadou, L., Berhe, B. A., Gonzalez, A. N., Serra‐Vinardell, J., Tamargo, R., Maniwang, E., Sorrentino, Z. A., Fujiwara, H., Grey, R. J., et al. (2017) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2017.11.001 · Cited by 39 · see citing works
Self-citationα-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
Delaidelli, A., Richner, M., Jiang, L., van der Laan, A., Christiansen, I. B. J., Ferreira, N., Nyengaard, J. R., Vægter, C. B., Jensen, P. H., Mackenzie, I. R., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01209-3 · Cited by 39 · see citing works
Microbiome–gut–brain dysfunction in prodromal and symptomatic Lewy body diseases
Ryman, S. G., Vakhtin, A. A., Richardson, S. P., & Lin, H. C. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11461-9 · Cited by 38 · see citing works
Differentiating Dementia with Lewy Bodies and Alzheimer's Disease by Deep Learning to Structural MRI
Nemoto, K., Sakaguchi, H., Kasai, W., Hotta, M., Kamei, R., Noguchi, T., Minamimoto, R., Arai, T., & Asada, T. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12835 · Cited by 37 · see citing works
Reconstruction of directed neuronal networks in a microfluidic device with asymmetric microchannels
Courte, J., Renault, R., Jan, A., Viovy, J., Peyrin, J., & Villard, C. (2018) · Methods in cell biology · doi:10.1016/bs.mcb.2018.07.002 · Cited by 37 · see citing works
Bidirectional Relationship Between Sleep Disturbances and Parkinson's Disease
Minakawa, E. N. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.927994 · Cited by 35 · see citing works
Rutherford, N. J., Dhillon, J.-K. S., Riffe, C. J., Howard, J. K., Brooks, M., & Giasson, B. I. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx371 · Cited by 33 · see citing works
Self-citationHass, E. W., Sorrentino, Z. A., Xia, Y., Lloyd, G. M., Trojanowski, J. Q., Prokop, S., & Giasson, B. I. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01242-2 · Cited by 34 · see citing works
Self-citationMild cognitive impairment in Parkinson's disease: current view
Jellinger, K. A. (2024) · Frontiers in Cognition · doi:10.3389/fcogn.2024.1369538 · Cited by 36 · see citing works
Λεάνδρου, Ε., Chalatsa, I., Anagnostou, D., Machalia, C., Semitekolou, M., Filippa, V., Makridakis, M., Vlahou, A., Anastasiadou, E., Vekrellis, K., et al. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00401-4 · Cited by 31 · see citing works
Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils
Xu, L., Ma, B., Nussinov, R., & Thompson, D. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00406 · Cited by 31 · see citing works
Current Management and Emerging Therapies in Multiple System Atrophy
Burns, M. R., & McFarland, N. R. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00890-x · Cited by 32 · see citing works
Hass, E. W., Sorrentino, Z. A., Lloyd, G. M., McFarland, N. R., Prokop, S., & Giasson, B. I. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01173-y · Cited by 31 · see citing works
Self-citationConte, C., Ingrassia, A. M. T., Brevé, J. J. P., Bol, J. G. J. M., Huisman, E., van Dam, A., Beccari, T., & van de Berg, W. D. J. (2023) · Cells · doi:10.3390/cells12101368 · Cited by 32 · see citing works
Effect of Levodopa Initiation on the Gut Microbiota in Parkinson's Disease
Palacios, N., Hannoun, A., Flahive, J., Ward, D. V., Goostrey, K. J., Deb, A., & Smith, K. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.574529 · Cited by 31 · see citing works
Dysfunction of motor cortices in Parkinson’s disease
Chu, H., Smith, Y., Lytton, W. W., Grafton, S. T., Villalba, R. M., Masilamoni, G. J., & Wichmann, T. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae294 · Cited by 32 · see citing works
Sekiya, H., Matsubara, T., Deture, M. A., & Dickson, D. W. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00900-6 · Cited by 30 · see citing works
Histone Deacetylase 6 and the Disease Mechanisms of α-Synucleinopathies
Lemos, M., & Stefanova, N. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.586453 · Cited by 28 · see citing works
Lloyd, G. M., Sorrentino, Z. A., Quintin, S. S., Gorion, K.-M. M., Bell, B. M., Paterno, G., Long, B., Prokop, S., & Giasson, B. I. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02425-4 · Cited by 27 · see citing works
Self-citationThe Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases
Lee, S., & Kovács, G. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084269 · Cited by 30 · see citing works
- Authors
- Uchihara, T., & Giasson, B. I.
- Affiliations
- Tokyo Metropolitan Institute of Medical Science (JP)
- University of Florida (US)
- Corresponding author
- Uchihara, Toshiki
- Giasson, Benoit I.
- Venue
- Acta Neuropathologica
- Published
- 2015-10-07
- Volume
- 131
- Issue
- 1
- Pages
- 49-73
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4698305
- OpenAlex
- W1854508876
- Cited by
- 249
- References
- 203
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 37 · 2023: 19 · 2022: 24 · 2021: 28 · 2020: 28 · 2019: 22 · 2018: 27 · 2017: 23 · 2016: 10 · 2015: 2
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Acta Neuropathologica (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25430057)
- Japan foundation for Neuroscience and Mental Health
- Mitsui Life Social Welfare Foundation
- Tokyo Metropolitan Institute of Medical Science
- National Institute of Neurological Disorders and Stroke (NS089622)
- National Parkinson Foundation (NPF-UN203)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- alpha-synuclein, Lewy bodies, Lewy neurites, neurodegeneration, neuroimmune activation, proteostasis, Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, synucleinopathies, neuroinflammation
- MeSH terms
- Animals, Axons, Brain, Humans, Parkinson Disease, Lewy Bodies, Lewy Body Disease, alpha-Synuclein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review