Are ubiquitination pathways central to Parkinson’s disease?

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin

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Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

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Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

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The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

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Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

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Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

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Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

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Proteasomal function is impaired in substantia nigra in Parkinson’s disease

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Parkin Protects against the Toxicity Associated with Mutant α-Synuclein

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Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

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CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

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Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson’s disease?

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Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult

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Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions

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Aggregated and Monomeric α-Synuclein Bind to the S6′ Proteasomal Protein and Inhibit Proteasomal Function

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Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity

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Parkin Suppresses Dopaminergic Neuron-Selective Neurotoxicity Induced by Pael-R in Drosophila

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α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

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PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

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Concurrence of α-synuclein and tau brain pathology in the Contursi kindred

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Immunocytochemical Co-localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the Elderly

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Complex relationship between Parkin mutations and Parkinson disease

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Parkin and the Molecular Pathways of Parkinson's Disease

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Animal Models of PD

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Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease

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A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

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Immunocytochemical localization of synphilin-1, an α-synuclein-associated protein, in neurodegenerative disorders

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MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE

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Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

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Discovering Endophenotypes for Major Depression

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The Ubiquitin Proteasome System in Neurodegenerative Diseases

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Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

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Back to the Future with Ubiquitin

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THE BIOCHEMISTRY OF PARKINSON'S DISEASE

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The mitochondrial energy transduction system and the aging process

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Molecular-level secondary structure, polymorphism, and dynamics of full-length α-synuclein fibrils studied by solid-state NMR

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Drug discovery in the ubiquitin–proteasome system

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Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein

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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

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Honey Bee Nest Thermoregulation: Diversity Promotes Stability

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Chronic Exposure to Rotenone Models Sporadic Parkinson's Disease in Drosophila melanogaster

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Toward constructing an endophenotype strategy for bipolar disorders

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Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

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Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease

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Small Molecule Inhibitors of α-Synuclein Filament Assembly

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Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease

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Loss of locus coeruleus neurons and reduced startle in parkin null mice

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Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

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Metabotropic glutamate receptors in the basal ganglia motor circuit

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Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death

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UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein

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Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function

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Caught in the Act

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Chemoenzymatic Semisynthesis of Proteins

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Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

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Ubiquitin–proteasome system and Parkinson's diseases

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An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

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α-Synuclein: Normal Function and Role in Neurodegenerative Diseases

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BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration

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Dieldrin-Induced Neurotoxicity: Relevance to Parkinson's Disease Pathogenesis

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More than just two peas in a pod: common amyloidogenic properties of tau and α-synuclein in neurodegenerative diseases

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Increased expression of p62 in expanded polyglutamine‐expressing cells and its association with polyglutamine inclusions

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Diverse Effects of Pathogenic Mutations of Parkin That Catalyze Multiple Monoubiquitylation in Vitro

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UBIQUITIN-DEPENDENT REGULATION OF THE SYNAPSE

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Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein

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MALDI Imaging of Formalin-Fixed Paraffin-Embedded Tissues: Application to Model Animals of Parkinson Disease for Biomarker Hunting

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Regulation of Akt signaling activation by ubiquitination

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Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

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Mitochondrial associated metabolic proteins are selectively oxidized in A30P α-synuclein transgenic mice—a model of familial Parkinson's disease

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Does α‐synuclein modulate dopaminergic synaptic content and tone at the synapse?

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Snaring the Function of α-Synuclein

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Signaling Through Monoubiquitination

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Sulphated tyrosines mediate association of chemokines and <i>Plasmodium vivax</i> Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC)

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Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration

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Degradation of BACE by the ubiquitin‐proteasome pathway

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A Drosophila Model of Mutant Human Parkin-Induced Toxicity Demonstrates Selective Loss of Dopaminergic Neurons and Dependence on Cellular Dopamine

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