Wei, Wenyi

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

Zhang, J., Bu, X., Wang, H., Zhu, Y., Geng, Y., Nihira, N. T., Tan, Y., Ci, Y., Wu, F., Dai, X., et al. (2018) · Nature

Cancer Immunotherapy and BiomarkersUbiquitin and proteasome pathways

Cited by 1,013

Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 804

The role of ubiquitination in tumorigenesis and targeted drug discovery

Deng, L., Meng, T., Chen, L., Wei, W., & Wang, P. (2020) · Signal Transduction and Targeted Therapy

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 744

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

Counter, C. M., Hahn, W. C., Wei, W., Caddle, S. D., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 649

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

Lee, S., Nakamura, E., Yang, H., Wei, W., Linggi, M. S., Sajan, M. P., Farese, R. V., Freeman, R. S., Carter, B. D., Kaelin, W. G., et al. (2005) · Cancer Cell

Adrenal and Paraganglionic TumorsCell death mechanisms and regulation

Cited by 527

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

Wei, W., Jin, J., Schlisio, S., Harper, J. W., & Kaelin, W. G. (2005) · Cancer Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 403

Role of p21 in Apoptosis and Senescence of Human Colon Cancer Cells Treated with Camptothecin

Han, Z., Wei, W., Dunaway, S., Darnowski, J. W., Calabresi, P., Sedivy, J., Hendrickson, E. A., Balan, K. V., Pantazis, P., & Wyche, J. H. (2002) · Journal of Biological Chemistry

Cancer therapeutics and mechanismsCancer-related Molecular Pathways

Cited by 262

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Liu, J., Chen, H., Kaniskan, H. Ü., Xie, L., Chen, X., Jin, J., & Wei, W. (2021) · Journal of the American Chemical Society

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 247

Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts

Wei, W., Hemmer, R. M., & Sedivy, J. M. (2001) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 217

PROTACs: A novel strategy for cancer therapy

Liu, J., Ma, J., Liu, Y., Xia, J., Li, Y., Wang, Z. P., & Wei, W. (2020) · Seminars in Cancer Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 186

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

Binné, U. K., Classon, M. K., Dick, F. A., Wei, W., Rape, M., Kaelin, W. G., Näär, A. M., & Dyson, N. J. (2007) · Nature Cell Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 175

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

Cao, J., Wan, L., Hacker, E., Dai, X., Lenna, S., Jimenez-Cervantes, C., Wang, Y., Leslie, N. R., Xu, G. X., Widlund, H. R., et al. (2013) · Molecular Cell

Melanoma and MAPK Pathwaysmelanin and skin pigmentation

Cited by 144

Targeting the acetylation signaling pathway in cancer therapy

Dang, F., & Wei, W. (2022) · Seminars in Cancer Biology

Histone Deacetylase Inhibitors ResearchCancer-related gene regulation

Cited by 109

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

Wei, W., Herbig, U., Wei, S., Dutriaux, A., & Sedivy, J. M. (2003) · The EMBO Reports

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 88

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

Nihira, N. T., Ogura, K., Shimizu, K., North, B. J., Zhang, J., Gao, D., Inuzuka, H., & Wei, W. (2017) · Science Signaling

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 82

TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors

Liu, J., Yu, X., Chen, H., Kaniskan, H. Ü., Xie, L., Chen, X., Jin, J., & Wei, W. (2022) · Journal of the American Chemical Society

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 73

Abolition of Cyclin-Dependent Kinase Inhibitor p16 Ink4a and p21 Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts

Wei, W., Jobling, W. A., Chen, W., Hahn, W. C., & Sedivy, J. M. (2003) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 68

Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

Shimizu, K., Gi, M., Suzuki, S., North, B. J., Watahiki, A., Fukumoto, S., Asara, J. M., Tokunaga, F., Wei, W., & Inuzuka, H. (2021) · Cell Reports

Ubiquitin and proteasome pathwaysCell death mechanisms and regulation

Cited by 62

Phosphorylation of Akt at the C-terminal tail triggers Akt Activation

Liu, P., Wang, Z., & Wei, W. (2014) · Cell Cycle

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 49

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., et al. (2017) · Molecular Cell

Bone Metabolism and DiseasesBone Tumor Diagnosis and Treatments

Cited by 46