Akassoglou, Katerina

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science

Histone Deacetylase Inhibitors ResearchSirtuins and Resveratrol in Medicine

Cited by 1,777

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 1,614

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 568

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience

Barrier Structure and Function StudiesBlood properties and coagulation

Cited by 527

Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer's disease model

Merlini, M., Rafalski, V. A., Rios Coronado, P. E., Gill, T. M., Ellisman, M., Muthukumar, G., Subramanian, K. S., Ryu, J. K., Syme, C. A., Davalos, D., et al. (2019) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 431

Chronic optical access through a polished and reinforced thinned skull

Drew, P. J., Shih, A. Y., Driscoll, J. D., Knutsen, P. M., Blinder, P., Davalos, D., Akassoglou, K., Tsai, P. S., & Kleinfeld, D. (2010) · Nature Methods

Optical Imaging and Spectroscopy TechniquesAdvanced Fluorescence Microscopy Techniques

Cited by 406

Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke

Baeten, K. M., & Akassoglou, K. (2011) · Developmental Neurobiology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 397

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Xu, T., Stewart, K. M., Wang, X., Liu, K., Xie, M., Ryu, J. K., Li, K., Ma, T., Wang, H., Ni, L., et al. (2017) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 395

The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

Adams, R. A., Bauer, J., Flick, M. J., Sikorski, S. L., Nuriel, T., Lassmann, H., Degen, J. L., & Akassoglou, K. (2007) · The Journal of Experimental Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 335

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, J. K., Petersen, M. A., Murray, S. G., Baeten, K. M., Meyer-Franke, A., Chan, J. P., Vagena, E., Bedard, C., Machado, M. R., Coronado, P. E. R., et al. (2015) · Nature Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 271

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Sayed, F. A., Telpoukhovskaia, M., Kodama, L., Li, Y., Zhou, Y., Le, D., Hauduc, A., Ludwig, C., Gao, F., Clelland, C., et al. (2018) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 229

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Ryu, J. K., Rafalski, V. A., Meyer-Franke, A., Adams, R. A., Poda, S. B., Rios Coronado, P. E., Pedersen, L. Ø., Menon, V., Baeten, K. M., Sikorski, S. L., et al. (2018) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 213

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Mendiola, A. S., Ryu, J. K., Bardehle, S., Meyer-Franke, A., Ang, K. K.-H., Wilson, C., Baeten, K. M., Hanspers, K., Merlini, M., Thomas, S., et al. (2020) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 199

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Czirr, E., Castello, N. A., Mosher, K. I., Castellano, J. M., Hinkson, I. V., Lucin, K. M., Baeza-Raja, B., Ryu, J. K., Li, L., Farina, S. N., et al. (2017) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 126

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Mendiola, A. S., Yan, Z., Dixit, K., Johnson, J. R., Bouhaddou, M., Meyer-Franke, A., Shin, M.-G., Yong, Y., Agrawal, A., MacDonald, E., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 124

Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis

Gaultier, A., Wu, X., Le Moan, N., Takimoto, S., Mukandala, G., Akassoglou, K., Campana, W. M., & Gonias, S. L. (2009) · Journal of Cell Science

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 118

Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor

Schachtrup, C., Lu, P., Jones, L. L., Lee, J. K., Lu, J., Sachs, B. D., Zheng, B., & Akassoglou, K. (2007) · Proceedings of the National Academy of Sciences

Nerve injury and regenerationCell Adhesion Molecules Research

Cited by 117

Fibrin drives thromboinflammation and neuropathology in COVID-19

Ryu, J. K., Yan, Z., Montano, M., Sozmen, E. G., Dixit, K., Suryawanshi, R. K., Matsui, Y., Helmy, E., Kaushal, P., Makanani, S. K., et al. (2024) · Nature

COVID-19 Clinical Research StudiesBlood properties and coagulation

Cited by 116

Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface

Bardehle, S., Rafalski, V. A., & Akassoglou, K. (2015) · Frontiers in Cellular Neuroscience

Blood properties and coagulationBlood Coagulation and Thrombosis Mechanisms

Cited by 76

Acute Vascular Disruption and Aquaporin 4 Loss After Stroke

Friedman, B., Schachtrup, C., Tsai, P. S., Shih, A. Y., Akassoglou, K., Kleinfeld, D., & Lyden, P. D. (2009) · Stroke

Ion Transport and Channel RegulationAcute Ischemic Stroke Management

Cited by 71

p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity

Baeza-Raja, B., Li, P., Le Moan, N., Sachs, B. D., Schachtrup, C., Davalos, D., Vagena, E., Bridges, D., Kim, C., Saltiel, A. R., et al. (2012) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 53

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks

Baeza-Raja, B., Eckel-Mahan, K., Zhang, L., Vagena, E., Tsigelny, I. F., Sassone-Corsi, P., Ptacek, L. J., & Akassoglou, K. (2013) · Journal of Neuroscience

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 44

Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

Miller, S. R., Luxem, K., Lauderdale, K., Nambiar, P., Honma, P. S., Ly, K. K., Bangera, S., Bullock, M., Shin, J., Kaliss, N., et al. (2024) · Cell Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 24

Fibrin-targeting immunotherapy for dementia

Kantor, A. B., Akassoglou, K., & Stavenhagen, J. B. (2023) · The Journal of Prevention of Alzheimer's Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 24