Takayanagi, Hiroshi

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell

Bone Metabolism and DiseasesSignaling Pathways in Disease

Cited by 2,701

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 1,778

T-Cell mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ.

Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., et al. (2000) · Nature

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 1,358

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, J. A., & Takayanagi, H. (2014) · Nature Medicine

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,153

Osteoprotection by semaphorin 3A

Hayashi, M., Nakashima, T., Taniguchi, M., Kodama, T., Kumanogoh, A., & Takayanagi, H. (2012) · Nature

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 606

Osteoimmunology: The conceptual framework unifying the immune and skeletal systems

Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 534

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, J. M., et al. (2008) · Immunity

T-cell and B-cell ImmunologyNF-κB Signaling Pathways

Cited by 503

The role of NFAT in osteoclast formation

TAKAYANAGI, H. (2007) · Annals of the New York Academy of Sciences

Bone Metabolism and DiseasesSignaling Pathways in Disease

Cited by 442

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, J. M., Takayanagi, H., et al. (2008) · Immunity

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 433

IL-17-producing γδ T cells enhance bone regeneration

Ono, T., Okamoto, K., Nakashima, T., Nitta, T., Hori, S., Iwakura, Y., & Takayanagi, H. (2016) · Nature Communications

Bone Metabolism and DiseasesT-cell and B-cell Immunology

Cited by 371

RANKL as the master regulator of osteoclast differentiation

Takayanagi, H. (2021) · Journal of Bone and Mineral Metabolism

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 175

Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging

Hayashi, M., Nakashima, T., Yoshimura, N., Okamoto, K., Tanaka, S., & Takayanagi, H. (2019) · Cell Metabolism

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 156

Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota

Nagashima, K., Sawa, S., Nitta, T., Tsutsumi, M., Okamura, T., Penninger, J. M., Nakashima, T., & Takayanagi, H. (2017) · Nature Immunology

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 154

Bone cell communication factors and Semaphorins

Negishi-Koga, T., & Takayanagi, H. (2012) · BoneKEy Reports

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 90

Effect of T cells on bone

Okamoto, K., & Takayanagi, H. (2023) · Bone

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 42