Bone cell communication factors and Semaphorins
Open accessAbstract
Bone tissue is continuously renewed throughout adult life by a process called 'remodeling', which involves a dynamic interplay among bone cells including osteoclasts, osteoblasts and osteocytes. For example, a tight coupling between bone resorption and formation is essential for the homeostasis of the skeletal system. Studies on the coupling mechanism in physiological and pathological settings have revealed that osteoclasts or osteoclastic bone resorption promote bone formation through the production of diverse coupling factors. The classical coupling factors are the molecules that promote bone formation after resorption, but there may be distinct mechanisms at work in various phases of bone remodeling. A recent study revealed that the Semaphorin 4D expressed by osteoclasts inhibits bone formation, which represents a mechanism by which coupling is dissociated. Furthermore, it has been demonstrated that osteoblastic expression of Semaphorin 3A exerts an osteoprotective effect by both suppressing bone resorption and increasing bone formation. Thus, recent advances have made it increasingly clear that bone remodeling is regulated by not only classical coupling factors, but also molecules that mediate cell-cell communication among bone cells. We propose that such factors be called bone cell communication factors, which control the delicate balance of the interaction of bone cells so as to maintain bone homeostasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
During bone remodeling, osteoclasts inhibit bone formation by expressing Sema4D to initiate bone resorption, while osteoblasts express Sema3A that suppresses bone resorption prior to bone formation.
“Thus, during the bone remodeling cycle, osteoclasts inhibit bone formation by expressing Sema4D, in order to initiate bone resorption, whereas osteoblasts express Sema3A that suppresses bone resorption, prior to bone formation [146] (Figure 5).”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [146]
Semaphorins are involved in bone cell communication during bone remodeling.
“Recently, it has been suggested that another category of molecules called semaphorins is involved in the bone cell communication during bone remodeling [146].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [146]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351 · see citing works
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483 · see citing works
Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
Seeman, E., & Delmas, P. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmra053077 · Cited by 2,108 · see citing works
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878 · see citing works
Self-citationEvidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778 · see citing works
Self-citationMatrix-embedded cells control osteoclast formation
Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304 · see citing works
Feng, X., & McDonald, J. M. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130203 · Cited by 1,272 · see citing works
TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165 · see citing works
Tetracycline-based histological analysis of bone remodeling
Frost, H. M. (1969) · Calcified Tissue Research · doi:10.1007/bf02058664 · Cited by 1,111 · see citing works
van Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893 · see citing works
Regulation of osteoblastogenesis and bone mass by Wnt10b
Bennett, C. N., Longo, K. A., Hahn, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., & MacDougald, O. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408742102 · Cited by 882 · see citing works
Osteoclast–osteoblast communication
Matsuo, K., & Irie, N. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.027 · Cited by 780 · see citing works
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works
Osteoclast-derived activity in the coupling of bone formation to resorption
Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 659 · see citing works
Osteoprotection by semaphorin 3A
Hayashi, M., Nakashima, T., Taniguchi, M., Kodama, T., Kumanogoh, A., & Takayanagi, H. (2012) · Nature · doi:10.1038/nature11000 · Cited by 606 · see citing works
Self-citationSemaphorin III is needed for normal patterning and growth of nerves, bones and heart
Behar, O., Golden, J. A., Mashimo, H. L., Schöen, F. J., & Fishman, M. C. (1996) · Nature · doi:10.1038/383525a0 · Cited by 583 · see citing works
Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805133106 · Cited by 556 · see citing works
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
Ishii, M., Egen, J. G., Klauschen, F., Meier-Schellersheim, M., Saeki, Y., Vacher, J., Proia, R. L., & Germain, R. N. (2009) · Nature · doi:10.1038/nature07713 · Cited by 515 · see citing works
Sims, N. A., & Gooi, J. H. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.07.016 · Cited by 513 · see citing works
Suppression of bone formation by osteoclastic expression of semaphorin 4D
Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R. H., & Takayanagi, H. (2011) · Nature Medicine · doi:10.1038/nm.2489 · Cited by 498 · see citing works
Self-citationGrowth factors for bone growth and repair: IGF, TGFβ and BMP
Linkhart, T. A., Mohan, S., & Baylink, D. J. (1996) · Bone · doi:10.1016/s8756-3282(96)00138-x · Cited by 440 · see citing works
Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts
Mayr‐Wohlfart, U., Waltenberger, J. L., Hausser, H., Keßler, S., Günther, K. ‐., Dehio, C., Puhl, W., & Brenner, R. E. (2002) · Bone · doi:10.1016/s8756-3282(01)00690-1 · Cited by 429 · see citing works
Semaphorins and their receptors in immune cell interactions
Suzuki, K., Kumanogoh, A., & Kikutani, H. (2008) · Nature Immunology · doi:10.1038/ni1553 · Cited by 400 · see citing works
Semaphorin Regulation of Cellular Morphology
Tran, T. S., Kolodkin, A. L., & Bharadwaj, R. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093554 · Cited by 388 · see citing works
Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone Remodelling
Hattner, R. S., Epker, B. N., & Frost, H. M. (1965) · Nature · doi:10.1038/206489a0 · Cited by 343 · see citing works
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation
Bennett, C. N., Ouyang, H., Li, Y., Zeng, Q., Gerin, I., Sousa, K. M., Lane, T. F., Krishnan, V., Hankenson, K. D., & MacDougald, O. A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070810 · Cited by 282 · see citing works
Kamiya, N., Ye, L., Kobayashi, T., Mochida, Y., Yamauchi, M., Kronenberg, H. M., Feng, J. Q., & Mishina, Y. M. (2008) · Development · doi:10.1242/dev.025825 · Cited by 275 · see citing works
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
Takegahara, N., Takamatsu, H., Toyofuku, T., Tsujimura, T., Okuno, T., Yukawa, K., Mizui, M., Yamamoto, M., Prasad, D. V., Suzuki, K., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1416 · Cited by 270 · see citing works
Howard, G. A., Bottemiller, B. L., Turner, R. T., Rader, J. I., & Baylink, D. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.3204 · Cited by 266 · see citing works
Regulation of bone remodeling by the central and peripheral nervous system
Elefteriou, F. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.016 · Cited by 229 · see citing works
Zelzer, E., & Olsen, B. R. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)65006-x · Cited by 223 · see citing works
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.
Grano, M., Galimi, F., Zambonin, G., Colucci, S. C., Cottone, E., Zallone, A. Z., & Comoglio, P. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7644 · Cited by 221 · see citing works
EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts
Allan, E. H., Häusler, K. D., Wei, T., Gooi, J. H., Quinn, J. M., Crimeen-Irwin, B., Pompolo, S., Sims, N. A., Gillespie, M. T., Onyia, J. E., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080324 · Cited by 199 · see citing works
Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J., & Sims, N. A. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080706 · Cited by 190 · see citing works
Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., & Matsuo, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807598200 · Cited by 175 · see citing works
Kubota, K., Sakikawa, C., Katsumata, M., Nakamura, T., & Wakabayashi, K. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.257 · Cited by 130 · see citing works
Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling
Sanchez-Fernandez, M. A., Gallois, A., Riedl, T., Jurdic, P., & Hoflack, B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003537 · Cited by 128 · see citing works
Catalano, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903527 · Cited by 128 · see citing works
Advances in osteoclast biology resulting from the study of osteopetrotic mutations
Segovia‐Silvestre, T., Neutzsky-Wulff, A. V., Sørensen, M. G., Christiansen, C., Bollerslev, J., Karsdal, M. A., & Henriksen, K. (2008) · Human Genetics · doi:10.1007/s00439-008-0583-8 · Cited by 127 · see citing works
The multi-functional role of insulin-like growth factor binding proteins in bone
Govoni, K. E., Baylink, D. J., & Mohan, S. (2004) · Pediatric Nephrology · doi:10.1007/s00467-004-1658-y · Cited by 120 · see citing works
Growth factor control of bone mass
CANALIS, E. M. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22322 · Cited by 117 · see citing works
Govoni, K. E., Wergedal, J. E., Florin, L., Angel, P. E., Baylink, D. J., & Mohan, S. (2007) · Endocrinology · doi:10.1210/en.2007-0608 · Cited by 109 · see citing works
Pennisi, A., Ling, W., Li, X., Khan, S., Shaughnessy, J. D., Barlogie, B., & Yaccoby, S. (2009) · Blood · doi:10.1182/blood-2009-01-201954 · Cited by 96 · see citing works
Gomez, C. G., Burt‐Pichat, B., Mallein‐Gérin, F., Merle, B., Delmas, P. D., Skerry, T. M., Vico, L., Malaval, L., & Chenu, C. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20512 · Cited by 91 · see citing works
Expression and function of semaphorin 7A in bone cells
Delorme, G., Saltel, F., Bonnelye, E., Jurdic, P., & Machuca‐Gayet, I. (2005) · Biology of the Cell · doi:10.1042/bc20040103 · Cited by 89 · see citing works
Fattore, A. D., Fornari, R., Wesenbeeck, L. V., de Freitas, F., Timmermans, J., Peruzzi, B., Cappariello, A., Rucci, N., Spera, G., Helfrich, M., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.071107 · Cited by 82 · see citing works
Okamoto, M., Murai, J., Imai, Y., Ikegami, D., Kamiya, N., Kato, S., Mishina, Y. M., Yoshikawa, H., & Tsumaki, N. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.477 · Cited by 80 · see citing works
Control of Bone Resorption by Semaphorin 4D Is Dependent on Ovarian Function
Dacquin, R., Domenget, C., Kumanogoh, A., Kikutani, H., Jurdic, P., & Machuca‐Gayet, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026627 · Cited by 73 · see citing works
Vadasz, Z., Haj, T., Halasz, K., Rosner, I., Slobodin, G., Attias, D., Kessel, A., Kessler, O., Neufeld, G., & Toubi, E. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3881 · Cited by 72 · see citing works
Sutton, A. L. M., Zhang, X., Dowd, D. R., Kharode, Y. P., Komm, B. S., & MacDonald, P. N. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0363 · Cited by 61 · see citing works
Koh, J., Oh, B., Lee, J. Y., Lee, J., Kimm, K., Kim, G. S., Park, B. L., Cheong, H. S., Shin, H. D., Hong, J. M., et al. (2005) · Journal of Human Genetics · doi:10.1007/s10038-005-0331-z · Cited by 54 · see citing works
Semaphorin signaling: molecular switches at the midline
Derijck, A. A. H. A., van Erp, S., & Pasterkamp, R. J. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.06.007 · Cited by 53 · see citing works
Tat, S. K., Pelletier, J., Amiable, N., Boileau, C., Lajeunesse, D., Duval, N., & Martel‐Pelletier, J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24029 · Cited by 50 · see citing works
Hughes, A., Kleine-Albers, J., Helfrich, M. H., Ralston, S. H., & Rogers, M. J. (2012) · Calcified Tissue International · doi:10.1007/s00223-011-9560-7 · Cited by 46 · see citing works
Osteoclasts Secrete the Chemotactic Cytokine Mim-1
Falany, M. L., Thames, A. M., McDonald, J. M., Blair, H. C., McKenna, M. A., Moore, R. E., Young, M. K., & Williams, J. P. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4307 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534 · see citing works
Self-citationSemaphorins and plexins as therapeutic targets
Worzfeld, T., & Offermanns, S. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4337 · Cited by 317 · see citing works
Zhou, X., Wahane, S., Friedl, M.-S., Kluge, M., Friedel, C. C., Avrampou, K., Zachariou, V., Guo, L., Zhang, B., He, X., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0597-7 · Cited by 275 · see citing works
Osteoclast-secreted SLIT3 coordinates bone resorption and formation
Kim, B.-J., Lee, Y.-S., Lee, S.-Y., Baek, W.-Y., Choi, Y. J., Moon, S. A., Lee, S. H., Kim, J.-E., Chang, E.-J., Kim, E.-Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91086 · Cited by 174 · see citing works
Understanding the local actions of lipids in bone physiology
During, A., Penel, G., & Hardouin, P. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.06.002 · Cited by 142 · see citing works
Coupling factors involved in preserving bone balance
Kim, B.-J., & Koh, J.-M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2981-y · Cited by 111 · see citing works
Daponte, V., Henke, K., & Drissi, H. (2024) · eLife · doi:10.7554/elife.95083 · Cited by 84 · see citing works
The Role of Semaphorin 3A in Bone Remodeling
Li, Z., Hao, J., Duan, X., Wu, N., Zhou, Z., Yang, F., Li, J., Zhao, Z., & Huang, S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00040 · Cited by 79 · see citing works
Terashima, A., & Takayanagi, H. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0417-1 · Cited by 76 · see citing works
Self-citationOrigin and evolution of plexins, semaphorins, and Met receptor tyrosine kinases
Junqueira Alves, C., Yotoko, K., Zou, H., & Friedel, R. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-38512-y · Cited by 72 · see citing works
Recent advances in bone-targeted therapy
Shi, C., Wu, T., He, Y., Zhang, Y., & Fu, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107473 · Cited by 72 · see citing works
Hutcheson, J. D., Goettsch, C., Rogers, M. A., & Aikawa, E. R. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.004 · Cited by 70 · see citing works
Xia, J., Swiercz, J. M., Bañón‐Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, C., Kumanogoh, A., Friedel, R. H., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.02.001 · Cited by 69 · see citing works
BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling
Zhou, Y., Yang, Y., Jing, Y., Yuan, T.-J., Sun, L., Tao, B., Liu, J., & Zhao, H. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3957 · Cited by 58 · see citing works
Two-faced immunology—from osteogenesis to bone resorption
Takayanagi, H. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.219 · Cited by 56 · see citing works
Self-citationAlves, C. J., Dariolli, R., Haydak, J. C., Kang, S., Hannah, T. C., Wiener, R. J., DeFronzo, S., Tejero, R., Gusella, G. L., Ramakrishnan, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26296-7 · Cited by 55 · see citing works
Liu, Y., Han, X., Bo, J.-X., & Ma, H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00375 · Cited by 49 · see citing works
Handa, K., Kiyohara, S., Yamakawa, T., Ishikawa, K., Hosonuma, M., Sakai, N., Karakawa, A., Chatani, M., Tsuji, M., Inagaki, K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50336-4 · Cited by 49 · see citing works
Self-citationMediero, A., Wilder, T., Shah, L. S., & Cronstein, B. N. (2018) · The FASEB Journal · doi:10.1096/fj.201700217r · Cited by 46 · see citing works
Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer
Yang, Y.-H., Buhamrah, A., Schneider, A., Lin, Y., Zhou, H., Bugshan, A., & Basile, J. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150151 · Cited by 45 · see citing works
Effects of mechanical repetitive load on bone quality around implants in rat maxillae
Uto, Y., Kuroshima, S., Nakano, T., Ishimoto, T., Inaba, N., Uchida, Y., & Sawase, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189893 · Cited by 45 · see citing works
Ruggiero, C., Baroni, M., Xenos, D., Parretti, L., Macchione, I. G., Bubba, V., Laudisio, A., Pedone, C., Ferracci, M., Magierski, R., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102130 · Cited by 46 · see citing works
Role of bone-anabolic agents in the treatment of breast cancer bone metastases
Suvannasankha, A., & Chirgwin, J. M. (2014) · Breast Cancer Research · doi:10.1186/s13058-014-0484-9 · Cited by 43 · see citing works
Osteoporosis: A role for lipids
During, A. (2020) · Biochimie · doi:10.1016/j.biochi.2020.08.004 · Cited by 44 · see citing works
Osteogenesis and Bone Regeneration
Yang, H. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.73955 · Cited by 42 · see citing works
Terpos, E., Ntanasis‐Stathopoulos, I., Christoulas, D., Bagratuni, T., Bakogeorgos, M., Gavriatopoulou, M., Eleutherakis‐Papaiakovou, E., Kanellias, N., Kastritis, E., & Dimopoulos, M. A. (2018) · Blood Cancer Journal · doi:10.1038/s41408-018-0075-6 · Cited by 36 · see citing works
TGFβ1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression
Tokunaga, T., Mokuda, S., Kohno, H., Yukawa, K., Kuranobu, T., Oi, K., Yoshida, Y., Hirata, S., & Sugiyama, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030800 · Cited by 36 · see citing works
Neuronal Control of Bone Remodeling
Corr, A. P., Smith, J. T., & Baldock, P. A. J. (2017) · Toxicologic Pathology · doi:10.1177/0192623317738708 · Cited by 35 · see citing works
Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice
Mizuhashi, K., Chaya, T., Kanamoto, T., Omori, Y., & Furukawa, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133704 · Cited by 34 · see citing works
Zhou, J. P., Fujiwara, T., Ye, S., Li, X., & Zhao, H. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-9967-7 · Cited by 34 · see citing works
Geng, Y., Zhao, X., Xu, J., Zhang, X., Hu, G., Fu, S., Dai, K., Chen, X., Patrick, Y. S.-H., & Zhang, X. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz030 · Cited by 34 · see citing works
Deng, X., Liang, L., Zhu, D., Zheng, L., Yu, J., Meng, X.-L., Zhao, Y., Sun, X., Pan, T., & Liu, Y. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.04.037 · Cited by 33 · see citing works
Emerging role of semaphorin-3A in autoimmune diseases
Liu, L., Li, X., Ye, D., & Pan, H. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0484-y · Cited by 29 · see citing works
Fernando, R. C., Mazzotti, D. R., de Azevedo, H. F. Z., Sandes, A. F., Rizzatti, E. G., de Oliveira, M. B., Alves, V. L. F., Eugênio, A. I. P., de Carvalho, F., Dalboni, M. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38314-8 · Cited by 28 · see citing works
Molecular and cellular basis of bone resorption
Gruber, R. (2014) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-014-0310-0 · Cited by 27 · see citing works
Investigation of the effects of semaphorin 3A on new bone formation in a rat calvarial defect model
Kenan, S., Onur, Ö., Solakoğlu, S., Kotil, T., Ramazanoğlu, M., Çelik, H. H., Ocak, M., Uzuner, B., & Fıratlı, E. (2018) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2018.12.010 · Cited by 27 · see citing works
Nanofiber composites in vascular tissue engineering
Fukunishi, T., Shoji, T., & Shinoka, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100173-8.00018-1 · Cited by 25 · see citing works
Sun, K., Zhu, J., Deng, Y., Xu, X., Kong, F., Sun, X., Huan, L., Ren, C., Sun, J., & Shi, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.629968 · Cited by 25 · see citing works
The brain in bone and fuel metabolism
Wee, N. K. Y., Kulkarni, R. N., Horsnell, H. L., & Baldock, P. A. J. (2015) · Bone · doi:10.1016/j.bone.2015.10.020 · Cited by 25 · see citing works
Zou, T., Dissanayaka, W. L., Jiang, S., Wang, S., Heng, B. C., Huang, X., & Zhang, C. (2016) · Journal of Endodontics · doi:10.1016/j.joen.2016.10.019 · Cited by 25 · see citing works
Deng, J., Cohen, D. J., Sabalewski, E. L., Duyn, C. V., Wilson, D. S., Schwartz, Z., & Boyan, B. D. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.11.030 · Cited by 24 · see citing works
Lu, W., Zheng, C., Zhang, H., Cheng, P., Miao, S., Wang, H., He, T., Fan, J., Hu, Y., Liu, H., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04821-9 · Cited by 23 · see citing works
During, A., Coutel, X., Bertheaume, N., Penel, G., & Olejnik, C. (2019) · Calcified Tissue International · doi:10.1007/s00223-019-00637-7 · Cited by 21 · see citing works
Xu, X., Fang, K., Wang, L., Liu, X., Zhou, Y., & Song, Y. (2019) · Stem Cells International · doi:10.1155/2019/2506463 · Cited by 20 · see citing works
Xu, X., Li, Y., Shi, L., He, K., Sun, Y. B., Ding, Y., Meng, B., Zhang, J., Xiang, L., Dong, J., et al. (2022) · EMBO Reports · doi:10.15252/embr.202153509 · Cited by 20 · see citing works
RetractedDeng, J., Cohen, D. J., Redden, J. T., McClure, M. J., Boyan, B. D., & Schwartz, Z. (2021) · Bone · doi:10.1016/j.bone.2021.116145 · Cited by 19 · see citing works
The role of secreted osteoclastogenic factor of activated T cells in bone remodeling
Zhang, R., Peng, S., & Zhu, G. (2022) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2022.07.001 · Cited by 18 · see citing works
Lu, W., Gao, B., Fan, J., Cheng, P., Hu, Y., Jie, Q., Luo, Z., & Yang, L. (2019) · Stem Cells International · doi:10.1155/2019/5037578 · Cited by 16 · see citing works
Bone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis
Kim, J. H., & Kim, N. (2020) · Chonnam Medical Journal · doi:10.4068/cmj.2020.56.2.94 · Cited by 16 · see citing works
Anastasilakis, A. D., Pοlyzos, S. A., Makras, P., Gkiomisi, A. I., Sakellariou, G. T., Savvidis, M. S., Παπαθεοδώρου, Α., Kokkoris, P., & Terpos, E. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.983078 · Cited by 15 · see citing works
LIS1 Regulates Osteoclastogenesis through Modulation of M-SCF and RANKL Signaling Pathways and CDC42
Ye, S., Fujiwara, T., Zhou, J. P., Varughese, K. I., & Zhao, H. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.15583 · Cited by 15 · see citing works
Semaphorin 3A in Ankylosing Spondylitis
Liao, H., Lin, Y., Chou, C., & Tsai, C. (2017) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2017.07.001 · Cited by 13 · see citing works
XAF1 promotes osteoclast apoptosis by antagonizing the XIAP-caspase axis
Zhang, M., Huang, Y., Bai, J., Xu, W., Shan, H., Sheng, L., Gao, X., Yu, H., Wang, S., Bai, C., et al. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.05.001 · Cited by 12 · see citing works
During, A. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.08.004 · Cited by 12 · see citing works
Co- and Triaxial Electrospinning for Stem Cell-based Bone Regeneration
Altundag‐Erdogan, Ö., Öteyaka, M. Ö., & Çelebi‐Saltik, B. (2023) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666230818094216 · Cited by 11 · see citing works
Lv, Z., Zhang, J., Liang, S., Zhou, C., Hu, D. Z., Brooks, D. J., Bouxsein, M., Lanske, B., Kostenuik, P. J., Gori, F., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.161932 · Cited by 11 · see citing works
The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone
Frost, K., Naylor, A. J., & McGettrick, H. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086935 · Cited by 10 · see citing works
The bone-heart axis in the pathogenesis of cardiovascular diseases: A narrative review
Vergatti, A., Abate, V., Iannuzzo, G., Barbato, A., FILIPPO, G. D., & Rendina, D. (2025) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2025.103872 · Cited by 10 · see citing works
Regulation of the Osteocyte Secretome with Aging and Disease
Kitase, Y., & Prideaux, M. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01089-w · Cited by 9 · see citing works
Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts
Yamakawa, T., Okamatsu, N., Ishikawa, K., Kiyohara, S., Handa, K., Hayashi, E., Sakai, N., Karakawa, A., Chatani, M., Tsuji, M., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115494 · Cited by 9 · see citing works
Self-citationKnani, L., Venditti, M., Rouis, H., Minucci, S., & Messaoudi, I. (2024) · Bone · doi:10.1016/j.bone.2024.117271 · Cited by 8 · see citing works
Semaphorin 7A: A novel marker of disease activity in Gaucher disease
Franco, M., Reihani, N., Dupuis, L., Collec, E., de Villemeur, T. B., de Person, M., Moussa, F., Berger, M. G., Belmatoug, N., & Kim, C. L. V. (2020) · American Journal of Hematology · doi:10.1002/ajh.25744 · Cited by 8 · see citing works
Recent advances in hydrogels for treating periodontal diseases and oral mucosal diseases
Gui, Y., Zhang, Y., Xu, H., Yang, W., Huang, H., Gu, M., & Sun, Y. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1605672 · Cited by 7 · see citing works
Effects of N-methyl-d-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice
Kiyohara, S., Sakai, N., Handa, K., Yamakawa, T., Ishikawa, K., Chatani, M., Karakawa, A., Azetsu, Y., Munakata, M., Ozeki, M., et al. (2020) · Journal of Oral Biosciences · doi:10.1016/j.job.2020.03.003 · Cited by 7 · see citing works
Self-citationInhibition of RANKL and Sema4D improves residual ridge resorption in mice
Hisamoto, M., Kimura, S., Iwata, K., Iwanaga, T., & Yokoyama, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-08016-3 · Cited by 7 · see citing works
Kuraji, R., Wu, Y., Hashimoto, S., Miyashita, Y., Mishiro, S., Ito, H., Kamarajan, P., Kapila, Y. L., & Numabe, Y. (2020) · Journal of Periodontal Research · doi:10.1111/jre.12824 · Cited by 7 · see citing works
Mahesh, L., Calvo‐Guirado, J. L., Shukla, S., Kumar, V. R., & Kumar, Y. R. (2020) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2020.03.011 · Cited by 6 · see citing works
Rawat, P., Ahmad, I., Vohora, D., Ahmad, F. J., & Talegaonkar, S. (2015) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-015-9213-x · Cited by 6 · see citing works
Semaphorin 3A: A Potential Target for Low Back Pain
Yin, P., Lv, H., Zhang, L., Zhang, L., & Tang, P. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00216 · Cited by 6 · see citing works
Exploring Omega-3′s Impact on the Expression of Bone-Related Genes in Meagre (Argyrosomus regius)
Luján-Amoraga, L., Delgado-Martín, B., Lourenço‐Marques, C., Gavaia, P. J., Bravo, J., Bandarra, N. M., Domínguez, D., Izquierdo, M. S., Pousão‐Ferreira, P., & Ribeiro, L. (2023) · Biomolecules · doi:10.3390/biom14010056 · Cited by 4 · see citing works
Gileta, A. F., Helgeson, M. L., Leonard, J. M. M., Pyle, L. C., Subramanian, H. P., Arndt, K., Hawkes, C. P., & del Gaudio, D. (2020) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62023 · Cited by 4 · see citing works
Bone and the Central Nervous System
Kulkarni, R. N., & Baldock, P. A. J. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-56192-9_13 · Cited by 4 · see citing works
Anatomy and Physiology of Skeletal Tissue: The Bone Cells
Brunetti, G., Colaianni, G., Colucci, S. C., & Grano, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-75110-8_1 · Cited by 4 · see citing works
Ovalbumin-induced asthma leads to bone loss with Piezo channel suppression in mice
Gao, W., Sawada, T., Cao, A., Yoshimoto, R. U., Yamaguchi, Y., Takahashi, Y., Fukuda, T., Ohsaki, Y., Aijima, R., Kadowaki, T., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08753-x · Cited by 3 · see citing works
Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling
de Molon, R. S., Tetradis, S., Vernal, R., Leite, F. R. M., & Dyke, T. E. V. (2026) · Journal of Periodontal Research · doi:10.1111/jre.70148 · Cited by 4 · see citing works
Chitosan based bionanocomposites in osteoporosis
Niranjan, M. K., Baghel, K., & Azam, Z. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821280-6.00014-3 · Cited by 2 · see citing works
Delattre, J., Bertheaume, N., Olejnik, C., & During, A. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02858-w · Cited by 1 · see citing works
Biological Events at the Interface Between the Radicular Part of a Dental Implant and Bone
Boyan, B. D., Lotz, E. M., Berger, M. B., Deng, J., Cohen, D. J., & Schwartz, Z. (2023) · Springer eBooks · doi:10.1007/978-3-031-37234-6_11 · Cited by 1 · see citing works
Wnt pathway in bone: knowledge structure and hot spots from 1993 to 2022
Liu, T., Zhao, J., Zhang, X., Wang, Y., Wang, W., & Song, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1279423 · Cited by 1 · see citing works
Traditional Chinese Medicine Therapy for Targeting Osteoblastogenesis
Liu, Y. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82451 · Cited by 1 · see citing works
Monteiro, A. C., & Bonomo, A. C. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.107278 · Cited by 1 · see citing works
Semaphorins in Bone Homeostasis
Hayashi, M., Nakashima, T., & Takayanagi, H. (2015) · Springer eBooks · doi:10.1007/978-4-431-54385-5_8 · Cited by 1 · see citing works
Self-citationGene Expression of Semaphorin 7A During Osteogenic Differentiation in Human Dental Follicle Cells
Kato, R., & Takahashi, K. (2016) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.25.263
Brincat, M., Galea, R. P., & Grixti, S. S. (2016)
Research Progress on the Effect of Semaphorin 3A on Immune Cells
史, 卓. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.119633
Bone Tumours - A Comprehensive Review of Selected Topics
Amarasekera, H. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100923
XAF1 is a promising target to regulate osteoclastogenesisPreprint
Zhou, X., Zhang, M., Huang, Y., Shan, H., Sheng, L., Bai, J., Gao, X., Tian, B., Ni, Y., Dong, Q., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3229867/v1
Akhatovich, M. S. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.52.008244
- Authors
- Negishi-Koga, T., & Takayanagi, H.
- Affiliations
- Japan Science and Technology Agency (JP)
- ORCID
- Takayanagi, Hiroshi
- Venue
- BoneKEy Reports
- Publisher
- Portico
- Published
- 2012-09-19
- Volume
- 1
- Pages
- 183
- ISSN
- 2047-6396 (ISSN-L)
- PMC
- PMC3810552
- OpenAlex
- W2023664549
- Cited by
- 90
- References
- 55
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 12 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 4
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BoneKEy Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Science and Technology Agency
- Exploratory Research for Advanced Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- bone remodeling, semaphorins, Sema4D, semaphorin 3A, osteoclasts, osteoblasts, osteocytes, bone resorption, bone formation, coupling coefficient, bone homeostasis, intercellular communication
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
