RANKL as the master regulator of osteoclast differentiation

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RANK is essential for osteoclast and lymph node development.

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The IRF Family Transcription Factors in Immunity and Oncogenesis

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

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IL-1 mediates TNF-induced osteoclastogenesis.

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TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.

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Osteoimmunology: evolving concepts in bone–immune interactions in health and disease

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RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

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NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

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Host defense against oral microbiota by bone-damaging T cells

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Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

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NF-κB-Mediated Regulation of Osteoclastogenesis

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Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

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Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

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RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

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TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

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Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

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NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.

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RANK‐Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis

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Immune complexes regulate bone metabolism through FcRγ signalling

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Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption

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OPG Production Matters Where It Happened

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Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice

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LOX Fails to Substitute for RANKL in Osteoclastogenesis

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RANKL‐Independent Osteoclastogenesis: A Long‐Standing Controversy

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The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

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The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies

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Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-κB signaling

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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGFβ1/SMAD3 signaling

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The role of TNF-α in osteoporosis, bone repair and inflammatory bone diseases: A review

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NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis

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Icariin ameliorates osteoporosis in ovariectomized rats by targeting Cullin 3/Nrf2/OH pathway for osteoclast inhibition

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Pharmacology-based molecular docking of 4-methylcatechol and its role in RANKL-mediated ROS/Keap1/Nrf2 signalling axis and osteoclastogenesis

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The immunological significance of tumor necrosis factor receptor-associated factors (TRAFs)

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The monocyte-to-osteoclast transition in rheumatoid arthritis: Recent findings

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Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration

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Polyphenols as potential preventers of osteoporosis: A comprehensive review on antioxidant and anti-inflammatory effects, molecular mechanisms, and signal pathways in bone metabolism

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Osteoclast biology in the single-cell era

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Redox signaling and antioxidant defense in osteoclasts

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Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues

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Curcumin-encapsulated exosomes in bisphosphonate-modified hydrogel microspheres promote bone repair through macrophage polarization and DNA damage mitigation

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Small-molecule amines: a big role in the regulation of bone homeostasis

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Profiling joint tissues at single-cell resolution: advances and insights

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Tussilagone inhibits osteoclastogenesis by modulating mitochondrial function and ROS production involved Nrf2 activation

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Review of potential medical treatments for middle ear cholesteatoma

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Guizhi Shaoyao Zhimu granules attenuate bone destruction in mice with collagen-induced arthritis by promoting mitophagy of osteoclast precursors to inhibit osteoclastogenesis

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Neutrophils in Inflammatory Bone Diseases

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Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo

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Osteoclastogenesis inhibitory phenolic derivatives produced by the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501

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Enhancing osteoinduction and bone regeneration of biphasic calcium phosphate scaffold thought modulating the balance between pro-osteogenesis and anti-osteoclastogenesis by zinc doping

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Circadian clock genes as promising therapeutic targets for bone loss

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Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats

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YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis

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Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis

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Multinucleation resets human macrophages for specialized functions at the expense of their identity

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Enhancement of Bone Tissue Regeneration with Multi‐Functional Nanoparticles by Coordination of Immune, Osteogenic, and Angiogenic Responses

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Extra-osseous Roles of the RANK-RANKL-OPG Axis with a Focus on Skeletal Muscle

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New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis

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Urolithin B suppresses osteoclastogenesis via inhibiting RANKL‐induced signalling pathways and attenuating ROS activities

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Dual-functional composite hydrogel platform: A “kill two birds with one stone” strategy for anti-infection and osseointegration in the treatment of infectious bone defects

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Porous 3D Scaffolds Enhance MSC Vitality and Reduce Osteoclast Activity

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Bone and the Unfolded Protein Response: In Sickness and in Health

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Osteoimmunology of Spondyloarthritis

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HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling

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