Otsuka, Atsushi

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

Seidel, J. A., Otsuka, A., & Kabashima, K. (2018) · Frontiers in Oncology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 1,360

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Zhong, F. L., Mamaï, O., Sborgi, L., Boussofara, L., Hopkins, R., Robinson, K., Szeverényi, I., Takeichi, T., Balaji, R., Lau, A., et al. (2016) · Cell

Inflammasome and immune disordersGenetic and rare skin diseases.

Cited by 440

The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling

Amano, W., Nakajima, S., Kunugi, H., Numata, Y., Kitoh, A., Egawa, G., Dainichi, T., Honda, T., Otsuka, A., Kimoto, Y., et al. (2015) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 259

Interleukin‐31 and interleukin‐31 receptor: New therapeutic targets for atopic dermatitis

Nakashima, C., Otsuka, A., & Kabashima, K. (2018) · Experimental Dermatology

Dermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 154

Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma

Otsuka, A., Dreier, J., Cheng, P. F., Nägeli, M., Lehmann, H., Felderer, L., Frew, I. J., Matsushita, S., Levesque, M. P., & Dummer, R. (2015) · Clinical Cancer Research

Hedgehog Signaling Pathway StudiesNonmelanoma Skin Cancer Studies

Cited by 106

Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients

Nonomura, Y., Otsuka, A., Nakashima, C., Seidel, J. A., Kitoh, A., Dainichi, T., Nakajima, S., Sawada, Y., Matsushita, S., Aoki, M., et al. (2016) · OncoImmunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 83

Hedgehog signaling in basal cell carcinoma

Otsuka, A., Levesque, M. P., Dummer, R., & Kabashima, K. (2015) · Journal of Dermatological Science

Hedgehog Signaling Pathway StudiesNonmelanoma Skin Cancer Studies

Cited by 72

Infiltration of PD-1-positive cells in combination with tumor site PD-L1 expression is a positive prognostic factor in cutaneous angiosarcoma

Honda, Y., Otsuka, A., Ono, S., Yamamoto, Y., Seidel, J. A., Morita, S., Hirata, M., Kataoka, T. R., Takenouchi, T., Fujii, K., et al. (2017) · OncoImmunology

Vascular Tumors and AngiosarcomasCancer Immunotherapy and Biomarkers

Cited by 72

Linking air pollution to atopic dermatitis

Kabashima, K., Otsuka, A., & Nomura, T. (2017) · Nature Immunology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 47

ADAMTSL5 Is upregulated in melanoma tissues in patients with idiopathic psoriasis vulgaris induced by nivolumab

Nonomura, Y., Otsuka, A., Ohtsuka, M., Yamamoto, T., Dummer, R., & Kabashima, K. (2017) · Journal of the European Academy of Dermatology and Venereology

Cancer Immunotherapy and BiomarkersPsoriasis: Treatment and Pathogenesis

Cited by 19

HLA-A*26 is correlated with response to nivolumab in Japanese melanoma patients

Ishida, Y., Otsuka, A., Tanaka, H., Levesque, M. P., Dummer, R., & Kabashima, K. (2017) · Journal of Investigative Dermatology

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

Cited by 13

Upregulation of granzyme B and interferon‐γ mRNA in responding lesions by treatment with nivolumab for metastatic melanoma: a case report

Anegawa, H., Otsuka, A., Kaku, Y., Nonomura, Y., Fujisawa, A., Endo, Y., & Kabashima, K. (2016) · Journal of the European Academy of Dermatology and Venereology

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

Cited by 9